Table 4. The frequency distribution of CYP2C19 genotypes, alleles and clopidogrel metabolic types for different types of stroke
From: Genetic variability in stroke patients: CYP2C19 polymorphisms unraveled
| Â | Â | Number | Atherothrombotic stroke(n=412) | Lacunar infarction(n=94) | Cerebral embolism(n=43) | X2 | P |
|---|---|---|---|---|---|---|---|
Genotype | CYP2C19*1/*1 | 191 | 136(71.20) | 40(20.94) | 15(7.85) | 13.275 | 0.209 |
CYP2C19*1/*2 | 233 | 173(74.25) | 37(15.88) | 23(9.87) | |||
CYP2C19*1/*3 | 30 | 26(86.67) | 3(10.0) | 1(3.33) | |||
CYP2C19*2/*2 | 65 | 53(81.54) | 9(13.85) | 3(4.62) | |||
CYP2C19*2/*3 | 29 | 24(82.76) | 4(13.79) | 1(3.45) | |||
CYP2C19*3/*3 | 1 | 0 | 1(100.0) | 0 | Â | Â | |
Allele | CYP2C19*1 | 645 | 471(73.02) | 120(18.60) | 54(8.37) | 4.886 | 0.299 |
CYP2C19*2 | 392 | 303(77.30) | 59(15.05) | 30(7.65) | |||
CYP2C19*3 | 61 | 50(81.97) | 9(14.75) | 2(3.28) | |||
Metabolic types | extensive metabolizers | 191 | 136(71.20) | 40(20.94) | 15(7.85) | 5.504 | 0.239 |
intermediate metabolizers | 263 | 199(75.67) | 40(15.21) | 24(9.13) | |||
poor metabolizers | 95 | 77(81.05) | 14(14.74) | 4(4.21) |