Skip to main content

Table 11 Gene Ontology categories enriched among the genes associated with progression-free survival

From: Cell cycle and aging, morphogenesis, and response to stimuli genes are individualized biomarkers of glioblastoma progression and survival

Gene Ontology Level Term P-value FDR Adjusted P-value Number of genes Genes
Biological process 3 cell cycle (GO:0007049) 3.89E-06 2.96E-04 11 Hras, Ppp1r15a, App, Calm2, Atf5, Pten, E2f3, Wee1, Tp53, Ccnd1, Nras
   death (GO:0016265) 3.18E-04 1.21E-02 92 App, Raf1, Atf5, Pten, Fadd, Hspa1a/Hspa1b, Tp53, Ppp1r15a
   response to biotic stimulus (GO:0009607) 4.11E-03 5.13E-02 62 Fadd, Hspa1a/Hspa1b, Clec2b, Ccnd1, Ifngr1
   response to abiotic stimulus (GO:0009628) 8.17E-03 6.90E-02 62 Fadd, Hspa1a/Hspa1b, Clec2b, Ccnd1, Ifngr1
  4 cell cycle process (GO:0022402) 4.26E-06 9.16E-04 10 App, Atf5, Pten, E2f3, Wee1, Tp53, Ccnd1, Nras, Hras, Ppp1r15a
  5 regulation of cell cycle (GO:0051726) 2.90E-07 1.22E-04 10 Wee1, Tp53, Ccnd1, App, Nras, Hras, Ppp1r15a, Atf5, Pten, E2f3
  6 regulation of progression through cell cycle (GO:0000074) 1.47E-07 9.24E-05 10 Tp53, Ccnd1, Nras, Hras, Ppp1r15a, App, Atf5, Pten, E2f3, Wee1
   cell death (GO:0008219) 2.13E-04 6.18E-02 92 Ppp1r15a, App, Raf1, Atf5, Pten, Fadd, Hspa1a/Hspa1b, Tp53
  7 programmed cell death (GO:0012501) 1.19E-04 2.23E-02 92 Ppp1r15a, App, Raf1, Atf5, Pten, Fadd, Hspa1a/Hspa1b, Tp53
  8 apoptosis (GO:0006915) 1.41E-04 5.21E-02 92 Ppp1r15a, App, Raf1, Atf5, Pten, Fadd, Hspa1a/Hspa1b, Tp53
Molecular function 3 pattern binding (GO:0001871) 3.26E-04 3.55E-02 3 Fstl1, App, Fgfr2
   carbohydrate binding (GO:0030246) 1.26E-03 6.89E-02 4 Fstl1, App, Fgfr2, Clec2b
  4 polysaccharide binding (GO:0030247) 3.01E-04 8.70E-02 3 Fstl1, App, Fgfr2
  1. 1 Only GO categories with False Discovery Rate (FDR) adjusted P-value < 0.1 and represented by three or more genes;
  2. 2 Although Hspa1a/Hspa1b are represented by the same probe (202581_at), these isoforms are counted as two units.