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Table 5 SAFE analysis of the KEGG pathway database
| αPathway (UP) | βSize | δq-value | εGO Term |
|---|---|---|---|
| Disease | |||
| KEGG:05014 | 92/54 | 0.1831 | Amyotrophic lateral sclerosis |
| DNA Metabolism | |||
| KEGG:03030 | 35/36 | 0.2048 | DNA replication |
| KEGG:03410 | 46/34 | 0.0003 | Base excision repair |
| KEGG:03420 | 42/44 | 0.0758 | Nucleotide excision repair |
| KEGG:03430 | 36/23 | 0.1367 | Mismatch repair |
| KEGG:03440 | 13/28 | 0.0003 | Homologous recombination |
| RNA Metabolism | |||
| KEGG:03018 | 55/54 | 0.0007 | RNA degradation |
| KEGG:03020 | 16/29 | 0.0296 | RNA polymerase |
| KEGG:00970 | 18/63 | 0.005 | Aminoacyl-tRNA biosynthesis |
| Mitochondrial Function | |||
| KEGG:00062 | 5/8 | 0.0381 | Fatty acid elongation in mitochondria |
| KEGG:00071 | 17/44 | 0.1726 | Fatty acid metabolism |
| Amino acid Metabolism | |||
| KEGG:00270 | 22/36 | 0.0261 | Cysteine and methionine metabolism |
| KEGG:00280 | 24/44 | 0.025 | Valine leucine and isoleucine degradation |
| KEGG:00290 | 7/11 | 0.0072 | Valine leucine and isoleucine biosynthesis |
| KEGG:00310 | 24/44 | 0.0385 | Lysine degradation |
| KEGG:00450 | 13/26 | 0.2048 | Selenoamino acid metabolism |
| Carbohydrate Metabolism | |||
| KEGG:00632 | 8/33 | 0.0003 | Benzoate degradation via CoA ligation |
| KEGG:00640 | 18/32 | 0.0381 | Propanoate metabolism |
| KEGG:00650 | 13/30 | 0.0003 | Butanoate metabolism |
| KEGG:00670 | 8/18 | 0.0177 | One carbon pool by folate |
| KEGG:00903 | 7/32 | 0.0425 | Limonene and pinene degradation |
| KEGG:00510 | 31/49 | 0.2155 | N-Glycan biosynthesis |
| Cell-Cell Communication | |||
| KEGG:04330 | 35/47 | 0.2288 | Notch signaling pathway |
| Chaperone-dependent protein transport | |||
| KEGG:03060 | 13/23 | 0.0573 | Protein export |
| Neuromuscular | |||
| KEGG:04260 | 46/77 | 0.1493 | Cardiac muscle contraction |
| UPS | |||
| KEGG:03050 | 42/45 | 0.032 | Proteasome |
| KEGG:04120 | 93/138 | 0.032 | Ubiquitin mediated proteolysis |
