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Table 5 Summary of prioritized genes associating MetS with cancer or inflammation

From: A comprehensive analysis of adiponectin QTLs using SNP association, SNP cis-effects on peripheral blood gene expression and gene expression correlation identified novel metabolic syndrome (MetS) genes with potential role in carcinogenesis and systemic inflammation

Biological mechanism Annotated genes Biological function Association identifier phenotype Relevance to cancer and/or inflammation Evidence
Cell cell adhesion and cell motility CDH18 A member of Calcium-dependent cell adhesion molecules subfamily type 2 N-cadherin, affects morphogenesis, growth and tissue homeostasis. weight, BMI, WC, HC and RQ Formation, growth, invasion and migration of malignant tumors, including Crohn’s disease and prostate cancer. Ectopic expression in breast cancer cells promotes motility, invasion and metastasis. SNP associations
CDH12 A member of the cadherin family. leptin Its homologue, CDH11, promotes synovial fibroblasts to secret pro-inflammatory cytokines. SNP associations
CTNND2 A partner molecule in the cadherin complex. It is a transcription activator. BMED Involvement in cancer as above SNP associations
  MYO10 An associate of the cadherin-catenin complex Leankg, LDLppd, adiponectin, IL-6 Function unclear, presumably involved in cancer as above SNP associations, SNP cis-effects on gene expression, expression/MetS phenotype correlations
Signal transduction AKAP6 An anchor protein for the AMP-activated protein kinase, a regulator of glycogen, sugar and lipid metabolism. HC, RQ and REE/Lean It might be involved in any cancer biology that is mediated through p53 SNP associations
PRKD1 A protein kinase that exerts its function by phosphorylating target proteins. WHR, Fatpct, Leanpct, and TNF-alpha It is involved in prostate cancer through E-cadherin phosphorylation SNP associations
  PPP2R3C It encodes the regulatory component of the protein ser/thr metallo-phosphatase. May regulate MCM3AP, which is a phosphorylation-dependent DNA replication initiation enzyme. Its homologue also play a role in the activation-induced cell death of B-cells. DI It may presumably be involved in cancer biology that relates MCM3. These include brain and thyroid cancer. It may also be involved in inflammation through its hypothetical function in B cell apoptosis. SNP associations
Transcription TAG A novel tumor antigen gene that is immunogenic. REE,FG, HOMA, HMED Testis cancer, skin melanoma and myelogenous leukemia. SNP associations
NPAS3 A transcription factor which regulates neurogenesis, glucose metabolism and the linkage of the two. Fatkg, Leankg, SubQF, TAF, REE/weight, TG, TC, cal. LDL-c, pulse, IL-1β, IL-6 It is a brain tumor suppressor and a marker for survival. SNP associations,
     SNP cis-effects on gene expression
NKX2-8 A homeobox transcription factor Weight and height Fetal liver and hepatocellular carcinoma and lung cancer SNP associations
BRMS1L A homologue to transcription factor BRMS1, which functions in a histone acetylase complex that repress target genes LMEDn and LDLppd Breast cancer progression and melanoma metastasis SNP associations
NOVA1 It is a neuron-specific tumor antigen that has RNA-binding activity and functions to ensure correct pre-mRNA splicing of target RNA BMI, WC, FG, FI, SI, AIR, HMED and sBP It is involved in the paraneoplastic motor disorder SNP associations
  EGLN3 It is a hydroxylase for target transcription factor HIF and mediates apoptosis in neuronal cells under development IGR and LDL-c It is involved in hemangioblastoma, clear cell renal carcinoma and formation of pheochromocytoma SNP associations
Protein sorting MARCH11 An ubiquitin ligase that is implicated in protein sorting and transport from trans-Golgi network to multivascular body. Fatkg, FI, SI and IL-1β Might be involved in pro-inflammatory cardiomyopathy. SNP associations
  FBXL7 Another ubiquitin ligase specific for phosphorylated protein degradation. WHR Might be involved in pro-inflammation as above SNP associations, SNP cis-effects on gene expression