Transcriptome signatures in Helicobacter pylori-infected mucosa identifies acidic mammalian chitinase loss as a corpus atrophy marker

Table 2 Gene expression in antrum and corpus tissue of Hp- individuals, for known antrum- and corpus-specific genes

Tissue specificity	Cell type	Description	Symbol	ID	Fold difference¹	p-value²
Corpus	ECL-cell	Histidine decarboxylase	HDC	ILMN_98661	11	1.0 x10^-4
	ECL/Parietal cell	Gastrin receptor 1	CCKBR	ILMN_9090	15	5.5 x 10^-4
	Parietal Cell	ATPase H⁺/K⁺ exchanging, beta	ATP4B	ILMN_12353	49	1.6 x 10^-3
	Parietal Cell	ATPase H⁺/K⁺ exchanging, alpha	ATP4A	ILMN_16471	45	4.5 x 10^-5
	Parietal cell	Gastric intrinsic factor	GIF	ILMN_18902	17	1.3 x 10^-2
	A-like/Gr cell	Ghrelin	GHRL	ILMN_19385	10	5.0 x 10^-2
	Chief cell	Pepsinogen	PGA5	ILMN_23664	48	2.4 x 10^-2
Antrum	G-cell	Gastrin	GAST	ILMN_23553	848	2.8 x 10^-5

¹ Fold difference when comparing gene expression levels in corpus vs. antrum for corpus specific genes, and antrum vs. corpus for antrum-specific genes.
² Antrum and corpus expression was compared using Student’s t-test; only values ≤ 0.05 are shown.

ISSN: 1755-8794