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Table 2 CpG sites associated with disease status (p ≤ 5×10 -7 )

From: Methylation of leukocyte DNA and ovarian cancer: relationships with disease status and outcome

Probe ID Ch Position (bp) Nearest genes Location of nearest gene (bp)# Location to Island^ Meta-Analysis§ Batch 1 Batch 2 Batch 3
       β ̂ P β ̂ P β ̂ P β ̂ P
cg04834572* 10 76868766 DUSP13 76854190-76868970 Shelf -0.65 1.6E-14 -0.82 2.1E-4 -0.55 6.0E-6 -0.73 1.1E-6
cg11722531 19 1449857 APC2 1450148-1473243 Shore -0.62 2.7E-13 -0.64 3.5E-3 -0.54 6.4E-6 -0.74 1.3E-6
cg10414058* 5 141017903 RELL2 141016517- Shore -0.94 6.3E-12 -1.13 3.5E-8 -0.71 7.1E-10 -1.05 9.0E-14
HDAC3 141020631
141000443-141016423
cg14580567 4 145567271 HHIP 145567148-145659881 Island -0.56 5.6E-11 -0.49 0.024 -0.55 3.8E-6 -0.61 9.3E-5
cg08245789 22 40289538 ENTHD1 40139049-40289794   -0.56 3.6E-10 -0.66 4.0E-3 -0.43 3.9E-4 -0.69 6.5E-6
cg27623214 19 58485726 C19orf18 58469805-58485902   -0.52 1.3E-9 -0.66 2.9E-3 -0.52 1.4E-5 -0.45 3.4E-3
cg23877385 15 59908652 GCNT3 59903982-59912210   -0.52 2.2E-9 -0.46 0.043 -0.53 1.3E-5 -0.52 6.3E-4
cg26150490 X 47863595 SPACA5 47863734-47869130 Island -0.50 3.6E-9 -0.34 0.10 -0.54 6.8E-6 -0.52 6.6E-4
ZNF182 47834250-47863394
cg22336401 9 140336227 ENTPD8 140328816-140335901 Island -0.50 5.3E-9 -0.27 0.24 -0.51 2.5E-5 -0.60 9.1E-5
cg20775254 2 95940705 PROM2 95940201-95957056   -0.53 6.1E-9 -0.58 5.3E-3 -0.41 8.2E-4 -0.69 5.6E-6
cg19280776* 8 82024586 PAG1 81880045-82024303 Shore 0.49 1.0E-8 0.60 6.2E-3 0.52 1.4E-5 0.38 0.013
cg07634191 8 27850178 SCARA5 27727399-27850369   -0.48 1.8E-8 -0.50 0.025 -0.39 1.2E-3 -0.61 4.5E-5
cg21244955 22 21192955 PI4KA 21061979-21213100   -0.49 2.2E-8 -0.47 0.039 -0.48 6.6E-5 -0.50 1.3E-3
cg18159180 6 43022213 CUL7 43005355-43021683 Shore -0.48 2.2E-8 -0.35 0.12 -0.57 2.8E-6 -0.41 8.0E-3
MRPL2 43021767-43027242
cg04439215 13 45768901 KCTD4 45766988-45775175   -0.49 2.4E-8 -0.65 4.4E-3 -0.37 2.2E-3 -0.60 1.0E-4
GTF2F2 45694631-45858240
cg26787239 5 132008525 IL4 132009678-132018370   -0.48 2.9E-8 -0.50 0.025 -0.50 3.4E-5 -0.43 4.8E-3
cg07259382 4 164536228 MARCH1 164445450-165304407   -0.48 3.0E-8 -0.58 8.5E-3 -0.43 3.1E-4 -0.50 1.2E-3
cg14808739 17 17741098 SREBF1 17714663-17740325 Shore -0.48 3.7E-8 -0.41 0.063 -0.52 2.3E-5 -0.44 3.8E-3
cg00065385 9 111623395 ACTL7A 111624603-111626035   -0.47 6.1E-8 -0.50 0.026 -0.49 5.0E-5 -0.43 6.9E-3
cg04721883 X 103499577 ESX1 103494719-103499599 Island -0.46 7.6E-8 -0.40 0.068 -0.38 1.7E-3 -0.62 4.6E-5
cg21400640 X 12992967 TMSB4X 12993226-12995346 Shore -0.46 1.1E-7 -0.50 0.029 -0.46 1.4E-4 -0.44 4.0E-3
cg11871280 12 60082038 SLC16A7 59989821-60183636   -0.45 1.7E-7 -0.24 0.28 -0.51 2.4E-5 -0.46 3.1E-3
cg09261015 X 103499647 ESX1 103494719-103499599 Island -0.45 2.1E-7 -0.46 0.046 -0.39 1.1E-3 -0.54 4.7E-4
cg18731813 X 100805683 ARMCX1 100805514-100809683 Shelf -0.44 2.4E-7 -0.23 0.30 -0.46 1.3E-4 -0.51 7.3E-4
cg23279136 X 74375966 ABCB7 74273105-74376132   -0.44 3.2E-7 -0.62 6.3E-3 -0.33 5.7E-3 -0.54 4.9E-4
cg02254461 3 39195904 CSRNP1 39183342-39195102 Shore -0.44 3.6E-7 -0.37 0.10 -0.48 9.1E-5 -0.42 6.1E-3
cg26246138 X 18372612 SCML2 18257433-18372844 Island -0.44 3.8E-7 -0.37 0.096 -0.37 2.3E-3 -0.57 1.6E-4
cg24959428* 1 89829951 GBP6 89829436-89853719   -0.44 4.1E-7 -0.50 0.025 -0.42 5.2E-4 -0.44 4.4E-3
cg05498681 20 35973318 SRC 35973088-36033821 Shore -0.44 4.8E-7 -0.17 0.45 -0.53 1.3E-5 -0.41 8.1E-3
cg01377911 19 49568036 NTF4 49564397-49567124   -0.43 5.0E-7 -0.38 0.086 -0.37 2.3E-3 -0.55 2.5E-4
  1. #Locations based on NCBI (http://www.ncbi.nlm.nih.gov), build 37.
  2. ^Shore CpG sites defined to be within +/- 2 kb from CpG island; Shelf CpG sites defined to be within +/- 2kb of CpG Shore.
  3. §All tests for heterogeneity of effects across the three batches were non-significant (p > 0.05); analysis adjusted for age at first live birth, alcohol use, smoking status, enrollment year, and recruitment state; a negative parameter estimate indicates lower methylation in the cases as compared to the control (e.g., cases where hypomethylated).
  4. *Same CpG site found to be associated with EOC risk (p ≤ 0.001) in a prior report [14].
  5. CpG sites near this gene found to be associated with EOC risk in a prior report [14].