Cancer Genome Atlas Research Network: Integrated genomic analyses of ovarian carcinoma. Nature. 2011, 474 (7353): 609-615. 10.1038/nature10166.
Article
Google Scholar
Cicek MS, Koestler DC, Fridley BL, Kalli KR, Armasu SM, Larson MC, Wang C, Winham SJ, Vierkant RA, Rider DN, Block MS, Klotzle B, Konecny G, Winterhoff BJ, Hamidi H, Shridhar V, Fan JB, Visscher DW, Olson JE, Hartmann LC, Bibikova M, Chien J, Cunningham JM, Goode EL: Epigenome-wide ovarian cancer analysis identifies a methylation profile differentiating clear-cell histology with epigenetic silencing of the HERG K+ channel. Hum Mol Genet. 2013, 22 (15): 3038-3047. 10.1093/hmg/ddt160.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rakyan VK, Down TA, Balding DJ, Beck S: Epigenome-wide association studies for common human diseases. Nat Rev Genet. 2011, 12 (8): 529-541. 10.1038/nrg3000.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tsai PC, Spector TD, Bell JT: Using epigenome-wide association scans of DNA methylation in age-related complex human traits. Epigenomics. 2012, 4 (5): 511-526. 10.2217/epi.12.45.
Article
CAS
PubMed
Google Scholar
Brennan K, Flanagan JM: Epigenetic epidemiology for cancer risk: harnessing germline epigenetic variation. Methods Mol Biol. 2012, 863: 439-465. 10.1007/978-1-61779-612-8_27.
Article
CAS
PubMed
Google Scholar
Brennan K, Flanagan JM: Is there a link between genome-wide hypomethylation in blood and cancer risk?. Cancer Prev Res (Phila). 2012, 5 (12): 1345-1357. 10.1158/1940-6207.CAPR-12-0316.
Article
CAS
Google Scholar
Shenker NS, Polidoro S, van Veldhoven K, Sacerdote C, Ricceri F, Birrell MA, Belvisi MG, Brown R, Vineis P, Flanagan JM: Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking. Hum Mol Genet. 2013, 22 (5): 843-851. 10.1093/hmg/dds488.
Article
CAS
PubMed
Google Scholar
Pedersen KS, Bamlet WR, Oberg AL, de Andrade M, Matsumoto ME, Tang H, Thibodeau SN, Petersen GM, Wang L: Leukocyte DNA methylation signature differentiates pancreatic cancer patients from healthy controls. PLoS One. 2011, 6 (3): e18223-10.1371/journal.pone.0018223.
Article
CAS
PubMed
PubMed Central
Google Scholar
Goode EL, Chenevix-Trench G, Song H, Ramus SJ, Notaridou M, Lawrenson K, Widschwendter M, Vierkant RA, Larson MC, Kjaer SK, Birrer MJ, Berchuck A, Schildkraut J, Tomlinson I, Kiemeney LA, Cook LS, Gronwald J, Garcia-Closas M, Gore ME, Campbell I, Whittemore AS, Sutphen R, Phelan C, Anton-Culver H, Pearce CL, Lambrechts D, Rossing MA, Chang-Claude J, Moysich KB, Goodman MT, et al: A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nat Genet. 2010, 42 (10): 874-879. 10.1038/ng.668.
Article
CAS
PubMed
PubMed Central
Google Scholar
Song H, Ramus SJ, Tyrer J, Bolton KL, Gentry-Maharaj A, Wozniak E, Anton-Culver H, Chang-Claude J, Cramer DW, DiCioccio R, Dork T, Goode EL, Goodman MT, Schildkraut JM, Sellers T, Baglietto L, Beckmann MW, Beesley J, Blaakaer J, Carney ME, Chanock S, Chen Z, Cunningham JM, Dicks E, Doherty JA, Durst M, Ekici AB, Fenstermacher D, Fridley BL, Giles G, et al: A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nat Genet. 2009, 41 (9): 996-1000. 10.1038/ng.424.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bojesen SE, Pooley KA, Johnatty SE, Beesley J, Michailidou K, Tyrer JP, Edwards SL, Pickett HA, Shen HC, Smart CE, Hillman KM, Mai PL, Lawrenson K, Stutz MD, Lu Y, Karevan R, Woods N, Johnston RL, French JD, Chen X, Weischer M, Nielsen SF, Maranian MJ, Ghoussaini M, Ahmed S, Baynes C, Bolla MK, Wang Q, Dennis J, McGuffog L, et al: Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet. 2013, 45 (4): 371-384. 10.1038/ng.2566. 384e371-372
Article
CAS
PubMed
PubMed Central
Google Scholar
Shen H, Fridley BL, Song H, Lawrenson K, Cunningham JM, Ramus SJ, Cicek MS, Tyrer J, Stram D, Larson MC, Kobel M, Consortium P, Ziogas A, Zheng W, Yang HP, Wu AH, Wozniak EL, Woo YL, Winterhoff B, Wik E, Whittemore AS, Wentzensen N, Weber RP, Vitonis AF, Vincent D, Vierkant RA, Vergote I, Van Den Berg D, Van Altena AM, Tworoger SS, et al: Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nat Commun. 2013, 4: 1628.
Article
PubMed
Google Scholar
Painter JN, Anderson CA, Nyholt DR, Macgregor S, Lin J, Lee SH, Lambert A, Zhao ZZ, Roseman F, Guo Q, Gordon SD, Wallace L, Henders AK, Visscher PM, Kraft P, Martin NG, Morris AP, Treloar SA, Kennedy SH, Missmer SA, Montgomery GW, Zondervan KT: Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis. Nat Genet. 2011, 43 (1): 51-54. 10.1038/ng.731.
Article
CAS
PubMed
Google Scholar
Teschendorff AE, Menon U, Gentry-Maharaj A, Ramus SJ, Gayther SA, Apostolidou S, Jones A, Lechner M, Beck S, Jacobs IJ, Widschwendter M: An epigenetic signature in peripheral blood predicts active ovarian cancer. PLoS One. 2009, 4 (12): e8274-10.1371/journal.pone.0008274.
Article
PubMed
PubMed Central
Google Scholar
Koestler DC, Marsit CJ, Christensen BC, Accomando W, Langevin SM, Houseman EA, Nelson HH, Karagas MR, Wiencke JK, Kelsey KT: Peripheral blood immune cell methylation profiles are associated with nonhematopoietic cancers. Cancer Epidemiol Biomarkers Prev. 2012, 21 (8): 1293-1302. 10.1158/1055-9965.EPI-12-0361.
Article
CAS
PubMed
PubMed Central
Google Scholar
Houseman EA, Accomando WP, Koestler DC, Christensen BC, Marsit CJ, Nelson HH, Wiencke JK, Kelsey KT: DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics. 2012, 13 (1): 86-10.1186/1471-2105-13-86.
Article
PubMed
PubMed Central
Google Scholar
Chen YA, Choufani S, Ferreira JC, Grafodatskaya D, Butcher DT, Weksberg R: Sequence overlap between autosomal and sex-linked probes on the Illumina HumanMethylation27 microarray. Genomics. 2011, 97 (4): 214-222. 10.1016/j.ygeno.2010.12.004.
Article
CAS
PubMed
Google Scholar
Grambsch PM, Therneau TM: Proportional hazards tests and diagnostics based on weighted residuals. Biometrika. 1994, 81 (3): 515-526. 10.1093/biomet/81.3.515.
Article
Google Scholar
Therneau TM, Grambsch PM, Fleming TR: Martingale-based residuals for survival models. Biometrika. 1990, 77: 147-160. 10.1093/biomet/77.1.147.
Article
Google Scholar
Sjodahl G, Lauss M, Gudjonsson S, Liedberg F, Hallden C, Chebil G, Mansson W, Hoglund M, Lindgren D: A systematic study of gene mutations in urothelial carcinoma; inactivating mutations in TSC2 and PIK3R1. PLoS One. 2011, 6 (4): e18583-10.1371/journal.pone.0018583.
Article
PubMed
PubMed Central
Google Scholar
Rao SK, Edwards J, Joshi AD, Siu IM, Riggins GJ: A survey of glioblastoma genomic amplifications and deletions. J Neurooncol. 2010, 96 (2): 169-179. 10.1007/s11060-009-9959-4.
Article
CAS
PubMed
Google Scholar
Philp AJ, Campbell IG, Leet C, Vincan E, Rockman SP, Whitehead RH, Thomas RJ, Phillips WA: The phosphatidylinositol 3’-kinase p85alpha gene is an oncogene in human ovarian and colon tumors. Cancer Res. 2001, 61 (20): 7426-7429.
CAS
PubMed
Google Scholar
Urick ME, Rudd ML, Godwin AK, Sgroi D, Merino M, Bell DW: PIK3R1 (p85alpha) is somatically mutated at high frequency in primary endometrial cancer. Cancer Res. 2011, 71 (12): 4061-4067. 10.1158/0008-5472.CAN-11-0549.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kondo T, Oue N, Yoshida K, Mitani Y, Naka K, Nakayama H, Yasui W: Expression of POT1 is associated with tumor stage and telomere length in gastric carcinoma. Cancer Res. 2004, 64 (2): 523-529. 10.1158/0008-5472.CAN-03-1196.
Article
CAS
PubMed
Google Scholar
Ning X, Yang S, Wang R, Zhang R, Guo L, Tie J, Cheng Y, Wang G, Wan S, Fang D: POT1 deficiency alters telomere length and telomere-associated gene expression in human gastric cancer cells. Eur J Cancer Prev. 2010, 19 (5): 345-351. 10.1097/CEJ.0b013e32833b4812.
Article
CAS
PubMed
Google Scholar
Wan SM, Tie J, Zhang YF, Guo J, Yang LQ, Wang J, Xia SH, Yang SM, Wang RQ, Fang DC: Silencing of the hPOT1 gene by RNA inference promotes apoptosis and inhibits proliferation and aggressive phenotype of gastric cancer cells, likely through up-regulating PinX1 expression. J Clin Pathol. 2011, 64 (12): 1051-1057. 10.1136/jclinpath-2011-200211.
Article
CAS
PubMed
Google Scholar
Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002, 300 (1): 2-8. 10.1124/jpet.300.1.2.
Article
CAS
PubMed
Google Scholar
Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008, 118 (2): 69-86. 10.1111/j.1600-0404.2008.01004.x.
Article
CAS
PubMed
Google Scholar
Salzman C, Miyawaki EK, le Bars P, Kerrihard TN: Neurobiologic basis of anxiety and its treatment. Harv Rev Psychiatry. 1993, 1 (4): 197-206. 10.3109/10673229309017080.
Article
CAS
PubMed
Google Scholar
Yeatman TJ: A renaissance for SRC. Nat Rev Cancer. 2004, 4 (6): 470-480. 10.1038/nrc1366.
Article
CAS
PubMed
Google Scholar
Katoh Y, Katoh M: Hedgehog signaling pathway and gastric cancer. Cancer Biol Ther. 2005, 4 (10): 1050-1054. 10.4161/cbt.4.10.2184.
Article
CAS
PubMed
Google Scholar
Pasca di Magliano M, Hebrok M: Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer. 2003, 3 (12): 903-911. 10.1038/nrc1229.
Article
PubMed
Google Scholar
Hayashi A, Horiuchi A, Kikuchi N, Hayashi T, Fuseya C, Suzuki A, Konishi I, Shiozawa T: Type-specific roles of histone deacetylase (HDAC) overexpression in ovarian carcinoma: HDAC1 enhances cell proliferation and HDAC3 stimulates cell migration with downregulation of E-cadherin. Int J Cancer. 2010, 127 (6): 1332-1346. 10.1002/ijc.25151.
Article
CAS
PubMed
Google Scholar
Khabele D, Son DS, Parl AK, Goldberg GL, Augenlicht LH, Mariadason JM, Rice VM: Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy. Cancer Biol Ther. 2007, 6 (5): 795-801. 10.4161/cbt.6.5.4007.
Article
CAS
PubMed
Google Scholar
Jin KL, Pak JH, Park JY, Choi WH, Lee JY, Kim JH, Nam JH: Expression profile of histone deacetylases 1, 2 and 3 in ovarian cancer tissues. J Gynecol Oncol. 2008, 19 (3): 185-190. 10.3802/jgo.2008.19.3.185.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jung P, Verdoodt B, Bailey A, Yates JR, Menssen A, Hermeking H: Induction of cullin 7 by DNA damage attenuates p53 function. Proc Natl Acad Sci U S A. 2007, 104 (27): 11388-11393. 10.1073/pnas.0609467104.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kim SS, Shago M, Kaustov L, Boutros PC, Clendening JW, Sheng Y, Trentin GA, Barsyte-Lovejoy D, Mao DY, Kay R, Jurisica I, Arrowsmith CH, Penn LZ: CUL7 is a novel antiapoptotic oncogene. Cancer Res. 2007, 67 (20): 9616-9622. 10.1158/0008-5472.CAN-07-0644.
Article
CAS
PubMed
Google Scholar
Jaiswal BS, Janakiraman V, Kljavin NM, Chaudhuri S, Stern HM, Wang W, Kan Z, Dbouk HA, Peters BA, Waring P, Dela Vega T, Kenski DM, Bowman KK, Lorenzo M, Li H, Wu J, Modrusan Z, Stinson J, Eby M, Yue P, Kaminker JS, de Sauvage FJ, Backer JM, Seshagiri S: Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation. Cancer Cell. 2009, 16 (6): 463-474. 10.1016/j.ccr.2009.10.016.
Article
CAS
PubMed
PubMed Central
Google Scholar
Peng B, Gu Y, Xiong Y, Zheng G, He Z: Microarray-assisted pathway analysis identifies MT1X & NFkappaB as mediators of TCRP1-associated resistance to cisplatin in oral squamous cell carcinoma. PLoS One. 2012, 7 (12): e51413-10.1371/journal.pone.0051413.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chun JH, Kim HK, Kim E, Kim IH, Kim JH, Chang HJ, Choi IJ, Lim HS, Kim IJ, Kang HC, Park JH, Bae JM, Park JG: Increased expression of metallothionein is associated with irinotecan resistance in gastric cancer. Cancer Res. 2004, 64 (14): 4703-4706. 10.1158/0008-5472.CAN-04-1063.
Article
CAS
PubMed
Google Scholar
Desmet CJ, Gallenne T, Prieur A, Reyal F, Visser NL, Wittner BS, Smit MA, Geiger TR, Laoukili J, Iskit S, Rodenko B, Zwart W, Evers B, Horlings H, Ajouaou A, Zevenhoven J, van Vliet M, Ramaswamy S, Wessels LF, Peeper DS: Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis. Proc Natl Acad Sci U S A. 2013, 110 (13): 5139-5144. 10.1073/pnas.1222085110.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ma DF, Kondo T, Nakazawa T, Niu DF, Mochizuki K, Kawasaki T, Yamane T, Katoh R: Hypoxia-inducible adenosine A2B receptor modulates proliferation of colon carcinoma cells. Hum Pathol. 2010, 41 (11): 1550-1557. 10.1016/j.humpath.2010.04.008.
Article
CAS
PubMed
Google Scholar
Barreto B, Feher O, Carvalho A, Cristo E, Neves E, Kowalski L, Reis L: Molecular classifiers as predictors of responsiveness to concomitant chemoradiotherapy in SCC of the larynx. AACR Meeting Abstracts 2008. 2008, 2008 (1_Annual_Meeting): 4142.
Google Scholar
Wazir U, Jiang WG, Sharma AK, Mokbel K: Guanine nucleotide binding protein beta 1: a novel transduction protein with a possible role in human breast cancer. Cancer Genomics Proteomics. 2013, 10 (2): 69-73.
CAS
PubMed
Google Scholar