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Table 3 Top Canonical Pathways (a) and Top Networks (b) Identified Using Ingenuity Pathway Analysis in Comparing 7 day vs Undifferentiated Cells: Top Molecules (c) and Top Transcription Factors (d) Identified Using Ingenuity Pathway Analysis in Comparing 7 day vs Undifferentiated Cells

From: Expression analysis of human adipose-derived stem cells during in vitro differentiation to an adipocyte lineage

(a)

(b)

(c)

(d)

Name

p-value

Associated Network Functions

Score

Name

Exp.Value

Transcription Regulator

P-value of overlap

Predicted Activation State

LPS/IL-1 Mediated Inhibition of RXR Function

6.17E-08

Lipid Metabolism, Small Molecule Biochemistry, Gastrointestinal Disease

39

PCK1

−40.310

PPARG

2.59E-22

Activated

Pyruvate Metabolism

6.28E-08

Drug Metabolism, Protein Synthesis, Cell Death

39

THRSP

−31.613

PPARA

1.02E-20

Activated

Fatty Acid Biosynthesis

3.49E-07

Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry

36

CA3

−28.877

SREBF1

5.80E-18

-

TR/RXR Activation

1.65E-06

Lipid Metabolism, Small Molecule Biochemistry, Energy Production

35

BBOX1

−28.336

SREBF2

1.60E-10

-

Glycolysis/Gluconeogenesis

1.34E-05

Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry

35

GPD1

−26.297

PPARGC1A

3.23E-10

-

    

PDE3B

−19.778

   
    

SCD

−17.679

   
    

CXCL6

−17.037

   
    

LGALS12

−16.318

   
    

FABP4

−14.682