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Table 3 Top Canonical Pathways (a) and Top Networks (b) Identified Using Ingenuity Pathway Analysis in Comparing 7 day vs Undifferentiated Cells: Top Molecules (c) and Top Transcription Factors (d) Identified Using Ingenuity Pathway Analysis in Comparing 7 day vs Undifferentiated Cells

From: Expression analysis of human adipose-derived stem cells during in vitro differentiation to an adipocyte lineage

(a) (b) (c) (d)
Name p-value Associated Network Functions Score Name Exp.Value Transcription Regulator P-value of overlap Predicted Activation State
LPS/IL-1 Mediated Inhibition of RXR Function 6.17E-08 Lipid Metabolism, Small Molecule Biochemistry, Gastrointestinal Disease 39 PCK1 −40.310 PPARG 2.59E-22 Activated
Pyruvate Metabolism 6.28E-08 Drug Metabolism, Protein Synthesis, Cell Death 39 THRSP −31.613 PPARA 1.02E-20 Activated
Fatty Acid Biosynthesis 3.49E-07 Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry 36 CA3 −28.877 SREBF1 5.80E-18 -
TR/RXR Activation 1.65E-06 Lipid Metabolism, Small Molecule Biochemistry, Energy Production 35 BBOX1 −28.336 SREBF2 1.60E-10 -
Glycolysis/Gluconeogenesis 1.34E-05 Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry 35 GPD1 −26.297 PPARGC1A 3.23E-10 -
     PDE3B −19.778    
     SCD −17.679    
     CXCL6 −17.037    
     LGALS12 −16.318    
     FABP4 −14.682