Table 4 Top Canonical Pathways (a) and Top Networks (b) Identified Using Ingenuity Pathway Analysis in Comparing 21 day vs 7 day

Name

p-value

ID

Associated Network Functions

Score

Name

Exp.Value

Transcription Regulator

P-value of overlap

Predicted Activation State

TREM1 Signaling

1.49E-08

1

Dermatological Diseases and Conditions, Genetic Disorder, Organismal Injury and Abnormalities

43

RSAD2

−33.001

IRF7

5.14E-37

-

Communication between Innate and Adaptive Immune Cells

2.27E-08

2

Cellular Response to Therapeutics, Cellular Assembly and Organization, Cellular Compromise

33

CMPK2

−16.965

STAT3

2.26E-27

-

Hepatic Fibrosis/Hepatic Stellate Cell Activation

6.52E-08

3

Inflammatory Disease, Neurological Disease, Cellular Function and Maintenance

31

ORM1/ORM2

−16.674

NFkB (complex)

2.48E-26

-

Interferon Signaling

8.34E-08

4

Lipid Metabolism, Small Molecule Biochemistry, Molecular Transport

31

CCL5

−15.185

IRF1

1.73E-22

-

Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

2E-07

5

Cellular Assembly and Organization, Cellular Function and Maintenance, Cellular Movement

31

LOC152742

−13.169

IRF3

5.54E-22

-

HERC6

−11.919

MX1

−11.250

OAS3

−11.105

IFI27

−10.472

TNFSF15

−10.235