Identification of epistatic interactions through genome-wide association studies in sporadic medullary and juvenile papillary thyroid carcinomas

Table 2 SNPs involved in significant interactions. Columns from left to right are: SNP identifier, region in which the SNP is located, gene, Frequencies in the cases, frequencies in the controls, ORs and 95 % of confidence interval (CI), nominal p-value and adjusted p-value

Analysis	SNP	Region	Gene	Frequency cases	Frequency controls	OR [95 % CI]	P-value	Adjusted p-value
sMTC	rs4758915	Intronic	CHFR	0.03704	0.02586	1.449 [0.4003–5.243]	0.5702	0.9812
sMTC	rs10402530	Downstream	AC016582.2	0.1944	0.1897	1.031 [0.5782–1.84]	0.9167	0.9936
sMTC	rs7835921	Intronic	C8orf37	0.4519	0.5086	0.7966 [0.5008–1.267]	0.3365	0.9669
sMTC	rs1287079	Downstream	RNU1-55P	0.3019	0.3664	0.7479 [0.4567–1.225]	0.2476	0.9569
jPTC	rs2235544	Intronic	DIO1	0.4667	0.5043	0.86 [0.487–1.519]	0.6032	0.9696
jPTC	rs16876356	Intronic	DMGDH	0.1167	0.2308	0.4403 [0.1891–1.025]	0.0518	0.9007
jPTC	rs17716031	Intronic	RP11-648K4.2	0.1034	0.1336	0.7481 [0.2964–1.888]	0.5379	0.9668
jPTC	rs10775207	Intronic	LOXL1	0.0167	0.0087	1.932 [0.1723–21.67]	0.5868	0.9668

ISSN: 1755-8794