Table 3 Direct and indirect gene-gene interactions obtained by GWAS-epistasis analyses in jPTC patients by VarElect
Direct GxG interactions | |||||
|---|---|---|---|---|---|
Significant interaction | Not significant interaction | ||||
Gene | Gene | CVV | Gene | Gene | CVV |
RP11-648k4,2 | DIO1 | 0.559 | ANKRD44 | STAT3 | 0.280 |
RP11-648k4,2 | TPO | 0.371 | |||
Indirect and significant interactions | |||||
Gene | Gene | CVV | Gene | Gene | CVV |
RP11-648K4.2 | ARHGAP22 | 0.559 | RP11-648k4,2 | PCYT1B | 0.650 |
ARHGEF11 | 0.555 | PLAUR | 0.851 | ||
ATP8B4 | 0.748 | PRICKLE1 | 0.557 | ||
CA6 | 0.744 | PRICKLE2 | 0.744 | ||
CHST8 | 0.555 | PRKAG2 | 0.556 | ||
CNTN2 | 0.557 | RNF14 | 0.650 | ||
COL19A1 | 0.651/0.555 | ROBO2 | 0.646 | ||
COL24A1 | 0.747 | RYR3 | 0.559 | ||
CRMP1 | 0.744 | SEMA6D | 0.558 | ||
DMGDH | 0.747 | SGCG | 0.557 | ||
EXTL3 | 0.747 | SKI | 0.557 | ||
FLI1 | 0.649 | SLC5A1 | 0.654 | ||
GALNS | 0.650 | SLC5A4 | 0.652 | ||
GALNT16 | 0.555/0.555 | SYNE1 | 0.650 | ||
GCN1L1 | 0.650/0.650 | TICRR | 0.844 | ||
GPR45 | 0.555 | UNC5B | 0.744 | ||
GRM7 | 0.740 | ZNF529 | 0.650 | ||
H19 | 0.556 | ZNF662 | 0.653 | ||
HDAC9 | 0.649 | ZNF793 | 0.653 | ||
KIFC3 | 0.937 | ANKRD44 | DOCK1 | 0.652 | |
KIR3DL1 | 0.744 | HDAC9 | 0.652 | ||
LOXL1 | 0.743 | PPP2R2A | 0.652 | ||
MAGED1 | 0.649 | PRKCB | 0.558 | ||
MAGI1 | 0.650 | SESN1 | 0.652 | ||
NCAM1 | 0.650 | SLC1A1 | 0.558 | ||
NPAS3 | 0.652 | WIPI1 | 0.942 | ||
NUP107 | 0.649 | DCC | C6orf100 | 0.651 | |
OPCML | 0.743 | ERI3 | 0.937 | ||
OR5AL1 | 0.744 | EXTL3 | 0.748 | ||
PARP1 | 0.950/0.650/0.650 | GCN1L1 | 0.558 | ||