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Table 2 All SNPs associated with DBP or SBP at p ≤ 1 × 10–4

From: Insights into the genetics of blood pressure in black South African individuals: the Birth to Twenty cohort

Phenotype Chromosome Gene/Region SNP ID a Base pair position a Alleles A1 Frequency c P-value d Beta e
A1 b A2 Bt20 YRI CEU
DBP 13 DACH1 | LOC440145 rs17240498 72,965,307 C T 0.01 0.00 0.18 4.91 × 10−6 7.93
21 ADAMTS5 | C21orf94 rs469709 28,801,007 A G 0.05 0.02 0.13 9.21 × 10−6 3.50
10 LOC642666 | LOC727960 rs12761063 82,533,425 T C 0.11 0.12 0.10 1.58 × 10−5 2.47
2 PLEKHH2 | LOC728819 rs13423605 43,886,460 C T 0.13 0.18 0.04 2.25 × 10−5 2.29
12 SCARB1 rs10846744 125,312,425 G C 0.23 0.24 0.85 2.49 × 10−5 −1.79
2 ARL6IP6 | LOC391453 rs2114653 153,648,587 G A 0.16 0.14 0.36 4.28 × 10−5 −1.94
19 EML2 | GIPR rs4994276 46,164,172 T C 0.15 0.20 0.19 5.87 × 10−5 −1.96
12 TRPV4 rs16939725 110,250,587 G A 0.14 0.14 0.02 7.08 × 10−5 −2.04
1 NOS1AP rs112468105 162,195,649 G C 0.01 0.02 0.00 7.18 × 10−5 6.69
12 DNAH10 rs6488908 124,377,814 G A 0.13 0.14 0.04 7.94 × 10−5 −2.02
SBP 11 MYRF rs11230796 61,529,267 G T 0.06 0.06 0.22 2.16 × 10 −7 6.12
11 MYRF rs400075 61,528,814 T C 0.06 0.06 0.22 2.88 × 10 −7 6.02
8 INTS10 | LPL rs55830938 19,735,188 G T 0.03 0.03 0.00 1.30 × 10−5 7.49
10 LOC100128511 | C10orf114 rs6482175 21,573,536 C T 0.08 0.11 0.19 1.42 × 10−5 4.31
13 DACH1 | LOC440145 rs17240498 72,965,307 C T 0.01 0.00 0.18 2.10 × 10−5 11.68
1 FMO4 | BAT2D1 rs10798391 171,389,938 T G 0.02 0.01 0.19 2.19 × 10−5 8.16
1 NOS1AP rs4657181 162,255,385 T A 0.05 0.02 0.56 4.04 × 10−5 −5.62
15 CYP19A1 rs10459592 51,536,141 G T 0.20 0.27 0.58 5.75 × 10−5 2.81
8 INTS10 | LPL rs73599609 19,756,974 C G 0.05 0.05 0.00 5.78 × 10−5 5.14
8 INTS10 | LPL rs73667448 19,747,475 C A 0.03 0.04 0.00 6.86 × 10−5 6.72
12 POC1B rs770373 89,818,289 T C 0.18 0.33 0.45 7.05 × 10−5 −2.95
11 STK33 rs1596888 8,455,344 T G 0.43 0.48 0.72 7.51 × 10−5 2.20
3 C3orf17 | BOC rs1881941 112,852,476 A T 0.12 0.72 0.93 7.66 × 10−5 3.39
22 FLJ46257 | FAM19A5 rs6519991 48,725,535 A G 0.17 0.16 0.10 8.31 × 10−5 −2.89
7 TAX1BP1 rs6944913 27,826,523 G A 0.02 <0.01 0.24 8.63 × 10−5 8.09
11 KCNQ1 rs1557647 2,551,363 A G 0.26 0.32 0.68 9.00 × 10−5 2.51
12 POC1B rs770374 89,818,022 T G 0.23 0.37 0.56 9.05 × 10−5 −2.62
  1. aAll SNP IDs and base pair positions are reported using GRCh37 (Genome Reference Consortium human genome Build 37)
  2. bA1 corresponds to the minor allele in the dataset
  3. cFrequencies of allele 1 are recorded for the dataset used in this study (Bt20) and for an African and European 1000 Genomes population - the Yoruba in Ibadan, Nigeria (YRI) and the Utah Residents with Northern and Western Ancestry (CEU)
  4. dp-value adjusted for age, sex, BMI and principal components. P-values that pass the “array-wide” significance threshold (p < 6.7 × 10−7) are shown in bold
  5. eBeta values are with respect to the minor allele in the sample. A positive beta indicates that the minor allele is associated with an increased blood pressure relative to the major allele, and vice versa