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Table 2 All SNPs associated with DBP or SBP at p ≤ 1 × 10–4

From: Insights into the genetics of blood pressure in black South African individuals: the Birth to Twenty cohort

Phenotype

Chromosome

Gene/Region

SNP ID a

Base pair position a

Alleles

A1 Frequency c

P-value d

Beta e

A1 b

A2

Bt20

YRI

CEU

DBP

13

DACH1 | LOC440145

rs17240498

72,965,307

C

T

0.01

0.00

0.18

4.91 × 10−6

7.93

21

ADAMTS5 | C21orf94

rs469709

28,801,007

A

G

0.05

0.02

0.13

9.21 × 10−6

3.50

10

LOC642666 | LOC727960

rs12761063

82,533,425

T

C

0.11

0.12

0.10

1.58 × 10−5

2.47

2

PLEKHH2 | LOC728819

rs13423605

43,886,460

C

T

0.13

0.18

0.04

2.25 × 10−5

2.29

12

SCARB1

rs10846744

125,312,425

G

C

0.23

0.24

0.85

2.49 × 10−5

−1.79

2

ARL6IP6 | LOC391453

rs2114653

153,648,587

G

A

0.16

0.14

0.36

4.28 × 10−5

−1.94

19

EML2 | GIPR

rs4994276

46,164,172

T

C

0.15

0.20

0.19

5.87 × 10−5

−1.96

12

TRPV4

rs16939725

110,250,587

G

A

0.14

0.14

0.02

7.08 × 10−5

−2.04

1

NOS1AP

rs112468105

162,195,649

G

C

0.01

0.02

0.00

7.18 × 10−5

6.69

12

DNAH10

rs6488908

124,377,814

G

A

0.13

0.14

0.04

7.94 × 10−5

−2.02

SBP

11

MYRF

rs11230796

61,529,267

G

T

0.06

0.06

0.22

2.16 × 10 −7

6.12

11

MYRF

rs400075

61,528,814

T

C

0.06

0.06

0.22

2.88 × 10 −7

6.02

8

INTS10 | LPL

rs55830938

19,735,188

G

T

0.03

0.03

0.00

1.30 × 10−5

7.49

10

LOC100128511 | C10orf114

rs6482175

21,573,536

C

T

0.08

0.11

0.19

1.42 × 10−5

4.31

13

DACH1 | LOC440145

rs17240498

72,965,307

C

T

0.01

0.00

0.18

2.10 × 10−5

11.68

1

FMO4 | BAT2D1

rs10798391

171,389,938

T

G

0.02

0.01

0.19

2.19 × 10−5

8.16

1

NOS1AP

rs4657181

162,255,385

T

A

0.05

0.02

0.56

4.04 × 10−5

−5.62

15

CYP19A1

rs10459592

51,536,141

G

T

0.20

0.27

0.58

5.75 × 10−5

2.81

8

INTS10 | LPL

rs73599609

19,756,974

C

G

0.05

0.05

0.00

5.78 × 10−5

5.14

8

INTS10 | LPL

rs73667448

19,747,475

C

A

0.03

0.04

0.00

6.86 × 10−5

6.72

12

POC1B

rs770373

89,818,289

T

C

0.18

0.33

0.45

7.05 × 10−5

−2.95

11

STK33

rs1596888

8,455,344

T

G

0.43

0.48

0.72

7.51 × 10−5

2.20

3

C3orf17 | BOC

rs1881941

112,852,476

A

T

0.12

0.72

0.93

7.66 × 10−5

3.39

22

FLJ46257 | FAM19A5

rs6519991

48,725,535

A

G

0.17

0.16

0.10

8.31 × 10−5

−2.89

7

TAX1BP1

rs6944913

27,826,523

G

A

0.02

<0.01

0.24

8.63 × 10−5

8.09

11

KCNQ1

rs1557647

2,551,363

A

G

0.26

0.32

0.68

9.00 × 10−5

2.51

12

POC1B

rs770374

89,818,022

T

G

0.23

0.37

0.56

9.05 × 10−5

−2.62

  1. aAll SNP IDs and base pair positions are reported using GRCh37 (Genome Reference Consortium human genome Build 37)
  2. bA1 corresponds to the minor allele in the dataset
  3. cFrequencies of allele 1 are recorded for the dataset used in this study (Bt20) and for an African and European 1000 Genomes population - the Yoruba in Ibadan, Nigeria (YRI) and the Utah Residents with Northern and Western Ancestry (CEU)
  4. dp-value adjusted for age, sex, BMI and principal components. P-values that pass the “array-wide” significance threshold (p < 6.7 × 10−7) are shown in bold
  5. eBeta values are with respect to the minor allele in the sample. A positive beta indicates that the minor allele is associated with an increased blood pressure relative to the major allele, and vice versa
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BMC Medical Genomics

ISSN: 1755-8794

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