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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Whole-genome bisulfite sequencing in systemic sclerosis provides novel targets to understand disease pathogenesis

Fig. 3

Illustration of SNP-CpG associations. (a) Methylation pattern of a nine-CpG DMR in FBN3. One SSc case was removed due to missing data. Methylation patterns exhibited a three-level stratification in this DMR where SSc cases were more prone to be hypomethylated. (b) Association between a C-to-A/G SNP at chr19:8138054 and significant loss of methylation in the DMR displayed in (a). (c) Methylation pattern of a three-CpG DMR in CDCA8. Methylation patterns exhibited a two-level stratification where SSc cases were more prone to be hypomethylated in this DMR. (d) Association between a G-to-A SNP at chr1:38156902 and significant increase in methylation in the DMR displayed in (c). Two SSc cases and one control with top three highest levels of methylation carried the A allele

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