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Table 6 The common and specific main pathways for BRCA and MBCA

From: EARN: an ensemble machine learning algorithm to predict driver genes in metastatic breast cancer

Number Pathways BRCA MBCA
Number of genes Name of genes Number of genes Name of genes
The specific main pathways for BRCA
 1 Extracellular matrix organization 8 DCN, FN1, ICAM1, ITGA4, ITGAM, ITGAV, ITGB3, ITGB5 0 None
 2 Immune System 15 FN1, GAB2, ICAM1, IL1RAPL1, IL1RN, IL2RB, ITGAM, ITGAV, ITGB5, JAK1, MSN, POU2F1, PTPN11, SMARCA4, SYK 0 None
 3 Hemostasis 12 EGF, FN1, GRB7, ITGA4, ITGAM, ITGAV, ITGB3, PIK3CG, PRKCZ, PTPN11, SERPINA1, SYK 0 None
 4 Developmental Biology 9 ACVR1B, GAB1, GAB2, GRB7, PTPN11, RELN, SMAD2, SMAD4, VLDLR 0 None
 5 Metabolism of RNA 6 CPSF1, CPSF3, PCF11, PRPF40A, SF3A1, SF3B1 0 None
The specific main pathways for MBCA
 6 Chromatin organization 0 None 7 TBL1XR1, NCOR1, HDAC3, GPS2, ACTB, KDM6B, PRMT1
 7 Circadian Clock 0 None 2 NCOR1, HDAC3
 8 Organelle biogenesis and maintenance 0 None 4 TBL1XR1, SIRT4, NCOR1, HDAC3
 9 Neuronal System 0 None 7 ABAT, KPNA2, PRKCG, CACNA1E, PLCB1, GRIN1, KRAS
 10 Metabolism 0 None 5 TBL1XR1, SIN3A, NCOR1, HDAC3, GPS2
The common main pathways for BRCA and MBCA
 11 Signal Transduction 25 ACVR1B, EGF, ERBB3, FLT1, FN1, GAB1, GAB2, GRB7, ITGAV, ITGB3, JAK1, NOTCH4, NR4A1, PARD3, PPARG, PRKCZ, PTEN, PTPN11, RUNX1, SMAD2, SMAD4, SMURF1, SYK, TFDP1, TGFBR2 25 ACTB, AR, BDNF, BUB1B, CBFB, COL4A3, FOXA1, KDR, KPNA2, KRAS, NCOR1, NOS3, PDGFD, PIK3R1, PKN2, PLCB1, PRKCD, PRKCG, PRMT1, PTPRJ, RUNX1, STAG1, STAT1, WAS, YWHAE
 12 Gene expression (Transcription) 19 ABL1, CBFB, CPSF1, CPSF3, MED23, NBN, NOTCH4, NR4A1, PCF11, POU2F1, PPARG, PTEN, PTPN11, RUNX1, SMAD2, SMAD4, SMARCA4, SMURF1, TFDP1 14 AR, BDNF, CBFB, GPS2, HDAC3, KLF4, KRAS, NCOR1, PRMT1, RUNX1, SIN3A, STAT1, TBL1XR1, YWHAE