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Table 2 Genotypic association of SNP variants T2DM, unadjusted and adjusted for age, sex, migration, family history, physical activity, BMI, WHR

From: The genetic susceptibility profile of type 2 diabetes and reflection of its possible role related to reproductive dysfunctions in the southern Indian population of Hyderabad

SNP

Model

Genotype

Frequency

Unadjusted

Adjusted

Cases (500)

Controls (500)

OR (CI 95%)

P value

OR (CI 95%)

P value

rs2241766

Over dominant

GT

0.81

0.25

12.46 (9.23–16.83)

1.71 × 10–73

13.76 (9.39–20.1)

2.47 × 10–51

TT-GG

0.19

0.75

–

–

–

–

rs6494730

Over dominant

GT

0.65

0.31

4.17 (3.2–5.43)

7.94 × 10–28

3.73 (2.69–5.16)

5.19 × 10–16

GG-TT

0.35

0.69

–

–

–

–

rs1799817

Log-additive

–

–

–

0.51 (0.4–0.65)

1.63 × 10–08

0.53 (0.39–0.71)

2.35 × 10–05

rs2059806

–

–

–

1.35 (1.14–1.61)

0.0006

1.4 (1.13–1.74)

0.0019

rs7248104*

Recessive

AA

0.20

0.15

1.38 (0.99–1.92)

0.050

1.28 (1.03–1.59)

0.027

GG-GA

0.80

0.85

–

–

–

–

rs11745088

Log-additive

–

–

–

0.27 (0.14–0.54)

4.85 × 10–05

0.32 (0.14–0.71)

0.003

rs9939609

Dominant

AT-AA

0.58

0.44

1.74 (1.36–2.24)

1.23 × 10–05

1.77 (1.29–2.42)

0.0003

TT

0.42

0.56

–

–

–

–

rs9940128

Log-additive

–

–

–

1.31 (1.10–1.57)

0.002

1.21 (0.97–1.51)

0.089#

rs1421085

Dominant

TC-CC

0.64

0.55

1.43 (1.11–1.84)

0.005

1.35 (0.98–1.85)

0.062#

TT

0.36

0.45

–

–

–

–

rs17817449

Log-additive

–

–

–

1.23 (1.02–1.49)

0.029

1.21 (0.96–1.54)

0.109#

rs8050136

Log-additive

–

–

–

1.23 (1.02–1.49)

0.030

1.23 (0.97–1.56)

0.080#

rs12584136

Over dominant

CA

0.05

0.09

0.52 (0.31–0.87)

0.011

0.54 (0.29–1.03)

0.054#

CC-AA

0.95

0.91

–

–

–

–

rs1805097

Log-additive

–

–

–

2.01 (1.08–3.74)

0.043

1.51 (0.71–3.21)

0.287#

rs1805094

Recessive

CC

0.99

0.98

0.20 (0.04–0.9)

0.015

0.28 (0.05–1.60)

0.115#

GG-GC

0.01

0.02

–

–

–

–

rs3802457

Log-additive

–

–

–

0.67 (0.48–0.93)

0.017

0.73 (0.48–1.1)

0.131#

rs2161829

Log-additive

–

–

–

1.16 (0.98–1.39)

0.089#

1.22 (0.98–1.51)

0.07#

  1. #P value not significant
  2. *Except rs7248104, all other SNPs are significant under log-additive model