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Table 2 Genotypic association of SNP variants T2DM, unadjusted and adjusted for age, sex, migration, family history, physical activity, BMI, WHR

From: The genetic susceptibility profile of type 2 diabetes and reflection of its possible role related to reproductive dysfunctions in the southern Indian population of Hyderabad

SNP Model Genotype Frequency Unadjusted Adjusted
Cases (500) Controls (500) OR (CI 95%) P value OR (CI 95%) P value
rs2241766 Over dominant GT 0.81 0.25 12.46 (9.23–16.83) 1.71 × 10–73 13.76 (9.39–20.1) 2.47 × 10–51
TT-GG 0.19 0.75
rs6494730 Over dominant GT 0.65 0.31 4.17 (3.2–5.43) 7.94 × 10–28 3.73 (2.69–5.16) 5.19 × 10–16
GG-TT 0.35 0.69
rs1799817 Log-additive 0.51 (0.4–0.65) 1.63 × 10–08 0.53 (0.39–0.71) 2.35 × 10–05
rs2059806 1.35 (1.14–1.61) 0.0006 1.4 (1.13–1.74) 0.0019
rs7248104* Recessive AA 0.20 0.15 1.38 (0.99–1.92) 0.050 1.28 (1.03–1.59) 0.027
GG-GA 0.80 0.85
rs11745088 Log-additive 0.27 (0.14–0.54) 4.85 × 10–05 0.32 (0.14–0.71) 0.003
rs9939609 Dominant AT-AA 0.58 0.44 1.74 (1.36–2.24) 1.23 × 10–05 1.77 (1.29–2.42) 0.0003
TT 0.42 0.56
rs9940128 Log-additive 1.31 (1.10–1.57) 0.002 1.21 (0.97–1.51) 0.089#
rs1421085 Dominant TC-CC 0.64 0.55 1.43 (1.11–1.84) 0.005 1.35 (0.98–1.85) 0.062#
TT 0.36 0.45
rs17817449 Log-additive 1.23 (1.02–1.49) 0.029 1.21 (0.96–1.54) 0.109#
rs8050136 Log-additive 1.23 (1.02–1.49) 0.030 1.23 (0.97–1.56) 0.080#
rs12584136 Over dominant CA 0.05 0.09 0.52 (0.31–0.87) 0.011 0.54 (0.29–1.03) 0.054#
CC-AA 0.95 0.91
rs1805097 Log-additive 2.01 (1.08–3.74) 0.043 1.51 (0.71–3.21) 0.287#
rs1805094 Recessive CC 0.99 0.98 0.20 (0.04–0.9) 0.015 0.28 (0.05–1.60) 0.115#
GG-GC 0.01 0.02
rs3802457 Log-additive 0.67 (0.48–0.93) 0.017 0.73 (0.48–1.1) 0.131#
rs2161829 Log-additive 1.16 (0.98–1.39) 0.089# 1.22 (0.98–1.51) 0.07#
  1. #P value not significant
  2. *Except rs7248104, all other SNPs are significant under log-additive model