Vakiti A, Mewawalla P. Acute myeloid leukemia. Treasure Island: StatPearls Publishing; 2021.
Google Scholar
Uhlen M, Fagerberg L, Hallstrom BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson A, Kampf C, Sjostedt E, Asplund A, et al. Proteomics. Tissue-based map of the human proteome. Science. 2015;347(6220):1260419.
Article
PubMed
CAS
Google Scholar
Leroy C, Belkina NV, Long T, Deruy E, Dissous C, Shaw S, Tulasne D. Caspase cleavages of the lymphocyte-oriented kinase prevent ezrin, radixin, and moesin phosphorylation during apoptosis. J Biol Chem. 2016;291(19):10148–61.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fukumura K, Yamashita Y, Kawazu M, Sai E, Fujiwara S, Nakamura N, Takeuchi K, Ando M, Miyazono K, Ueno T, et al. STK10 missense mutations associated with anti-apoptotic function. Oncol Rep. 2013;30:1542–8.
Article
CAS
PubMed
Google Scholar
Arora S, Gonzales IM, Hagelstrom RT, Beaudry C, Choudhary A, Sima C, Tibes R, Mousses S, Azorsa DO. RNAi phenotype profiling of kinases identifies potential therapeutic targets in Ewing’s sarcoma. Mol Cancer. 2010;9(1):218.
Article
PubMed
PubMed Central
CAS
Google Scholar
Degenhardt Y, Lampkin T. Targeting Polo-like kinase in cancer therapy. Clin Cancer Res. 2010;16(2):384–9.
Article
CAS
PubMed
Google Scholar
Cortes J, Podoltsev N, Kantarjian H, Borthakur G, Zeidan AM, Stahl M, Taube T, Fagan N, Rajeswari S, Uy GL. Phase 1 dose escalation trial of volasertib in combination with decitabine in patients with acute myeloid leukemia. Int J Hematol. 2021;113(1):92–9.
Article
CAS
PubMed
Google Scholar
Brandwein JM. Targeting polo-like kinase 1 in acute myeloid leukemia. Ther Adv Hematol. 2015;6(2):80–7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liu Z, Sun Q, Wang X. PLK1, a potential target for cancer therapy. Transl Oncol. 2017;10(1):22–32.
Article
PubMed
Google Scholar
Raab CA, Raab M, Becker S, Strebhardt K. Non-mitotic functions of polo-like kinases in cancer cells. Biochim Biophys Acta Rev Cancer. 2021;1875(1):188467.
Article
CAS
PubMed
Google Scholar
Zhang L, Lu SY, Guo R, Ma JX, Tang LY, Wang JJ, Shen CL, Lu LM, Liu J, Wang ZG, et al. STK10 knockout inhibits cell migration and promotes cell proliferation via modulating the activity of ERM and p38 MAPK in prostate cancer cells. Exp Ther Med. 2021;22(2):851.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang L, Qi Y, Xiong Y, Peng Z, Ma Q, Zhang Y, Song J, Zheng J. Ezrin–radixin–moesin binding phosphoprotein 50 (EBP50) suppresses the metastasis of breast cancer and HeLa cells by inhibiting matrix metalloproteinase-2 activity. Anticancer Res. 2017;37(8):4353–60.
CAS
PubMed
Google Scholar
Proudfit A, Bhunia N, Pore D, Parker Y, Lindner D, Gupta N. Pharmacologic inhibition of Ezrin–Radixin–Moesin phosphorylation is a novel therapeutic strategy in rhabdomyosarcoma. Sarcoma. 2020;2020:9010496.
Article
PubMed
PubMed Central
CAS
Google Scholar
Lipreri da Silva JC, Coelho-Silva JL, Lima K, Vicari HP, Lazarini M, Costa-Lotufo LV, Traina F, Machado-Neto JA. Comprehensive analysis of cytoskeleton regulatory genes identifies ezrin as a prognostic marker and molecular target in acute myeloid leukemia. Cell Oncol (Dordr). 2021, Preprint.
Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45(W1):W98–102.
Article
CAS
PubMed
PubMed Central
Google Scholar
Vivian J, Rao AA, Nothaft FA, Ketchum C, Armstrong J, Novak A, Pfeil J, Narkizian J, Deran AD, Musselman-Brown A, et al. Toil enables reproducible, open source, big biomedical data analyses. Nat Biotechnol. 2017;35(4):314–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Stirewalt DL, Meshinchi S, Kopecky KJ, Fan W, Pogosova-Agadjanyan EL, Engel JH, Cronk MR, Dorcy KS, McQuary AR, Hockenbery D, et al. Identification of genes with abnormal expression changes in acute myeloid leukemia. Genes Chromosom Cancer. 2008;47(1):8–20.
Article
CAS
PubMed
Google Scholar
Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 2019;10(1):1523.
Article
PubMed
PubMed Central
CAS
Google Scholar
Pan JB, Hu SC, Shi D, Cai MC, Li YB, Zou Q, Ji ZL. PaGenBase: a pattern gene database for the global and dynamic understanding of gene function. PLoS ONE. 2013;8(12):e80747.
Article
PubMed
PubMed Central
CAS
Google Scholar
Han H, Cho JW, Lee S, Yun A, Kim H, Bae D, Yang S, Kim CY, Lee M, Kim E, et al. TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions. Nucleic Acids Res. 2018;46(D1):D380–6.
Article
CAS
PubMed
Google Scholar
Szklarczyk D, Gable AL, Nastou KC, Lyon D, Kirsch R, Pyysalo S, Doncheva NT, Legeay M, Fang T, Bork P, et al. The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets. Nucleic Acids Res. 2021;49(D1):D605–12.
Article
CAS
PubMed
Google Scholar
Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498–504.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bindea G, Mlecnik B, Tosolini M, Kirilovsky A, Waldner M, Obenauf AC, Angell H, Fredriksen T, Lafontaine L, Berger A, et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity. 2013;39(4):782–95.
Article
CAS
PubMed
Google Scholar
Liquori A, Ibañez M, Sargas C, Sanz MÁ, Barragán E, Cervera J. Acute Promyelocytic leukemia: a constellation of molecular events around a single PML-RARA fusion gene. Cancers (Basel). 2020;12(3):624.
Article
CAS
Google Scholar
Konstandin NP, Pastore F, Herold T, Dufour A, Rothenberg-Thurley M, Hinrichsen T, Ksienzyk B, Tschuri S, Schneider S, Hoster E, et al. Genetic heterogeneity of cytogenetically normal AML with mutations of CEBPA. Blood Adv. 2018;2(20):2724–31.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shao X, Liu Y, Li Y, Xian M, Zhou Q, Yang B, Ying M, He Q. The HER2 inhibitor TAK165 sensitizes human acute myeloid leukemia cells to retinoic acid-induced myeloid differentiation by activating MEK/ERK mediated RARα/STAT1 axis. Sci Rep. 2016;6:24589.
Article
CAS
PubMed
PubMed Central
Google Scholar
Vagapova ER, Lebedev TD, Tikhonova AD, Goikhman BV, Ivanenko KA, Spirin PV, Prassolov VS. High expression level of SP1, CSF1R, and PAK1 correlates with sensitivity of leukemia cells to the antibiotic mithramycin. Mol Biol. 2020;54(3):522–8.
Article
CAS
Google Scholar
Welch JS. Patterns of mutations in TP53 mutated AML. Best Pract Res Clin Haematol. 2018;31(4):379–83.
Article
PubMed
PubMed Central
Google Scholar
Rossi G, Minervini MM, Carella AM, Melillo L, Cascavilla N. Wilms’ tumor gene (WT1) expression and minimal residual disease in acute myeloid leukemia. In: van den Heuvel-Eibrink MM, editor. Wilms tumor. Brisbane: Codon Publications Copyright; 2016.
Google Scholar
Carlsten M, Jaras M. Natural killer cells in myeloid malignancies: immune surveillance, NK cell dysfunction, and pharmacological opportunities to bolster the endogenous NK cells. Front Immunol. 2019;10:2357.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sanchez-Correa B, Campos C, Pera A, Bergua JM, Arcos MJ, Bañas H, Casado JG, Morgado S, Duran E, Solana R, et al. Natural killer cell immunosenescence in acute myeloid leukaemia patients: new targets for immunotherapeutic strategies? Cancer Immunol Immunother. 2016;65(4):453–63.
Article
CAS
PubMed
Google Scholar
Boddu P, Kantarjian H, Garcia-Manero G, Allison J, Sharma P, Daver N. The emerging role of immune checkpoint based approaches in AML and MDS. Leuk Lymphoma. 2018;59(4):790–802.
Article
CAS
PubMed
Google Scholar
Piccaluga PP, Navari M, De Falco G, Ambrosio MR, Lazzi S, Fuligni F, Bellan C, Rossi M, Sapienza MR, Laginestra MA, et al. Virus-encoded microRNA contributes to the molecular profile of EBV-positive Burkitt lymphomas. Oncotarget. 2016;7:224–40.
Article
PubMed
Google Scholar
Walter SA, Cutler RE Jr, Martinez R, Gishizky M, Hill RJ. Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue. J Biol Chem. 2003;278(20):18221–8.
Article
CAS
PubMed
Google Scholar
Lyengar V, Shimanovsky A. Leukemia. Treasure Island: StatPearls Publishing; 2021.
Google Scholar
Ostermann G, Weber KS, Zernecke A, Schröder A, Weber C. JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes. Nat Immunol. 2002;3(2):151–8.
Article
CAS
PubMed
Google Scholar
Barber DF, Faure M, Long EO. LFA-1 contributes an early signal for NK cell cytotoxicity. J Immunol (Baltimore, Md: 1950). 2004;173(6):3653–9.
Article
CAS
Google Scholar
Losse J, Zipfel PF, Józsi M. Factor H and factor H-related protein 1 bind to human neutrophils via complement receptor 3, mediate attachment to Candida albicans, and enhance neutrophil antimicrobial activity. J Immunol (Baltimore, Md: 1950). 2010;184(2):912–21.
Article
CAS
Google Scholar
Wang J, Hao JP, Uddin MN, Wu Y, Chen R, Li DF, Xiong DQ, Ding N, Yang JH, Ding XS. Identification and validation of inferior prognostic genes associated with immune signatures and chemotherapy outcome in acute myeloid leukemia. Aging (Albany NY). 2021;13(12):16445–70.
Article
CAS
Google Scholar
Yang Q, Li K, Li X, Liu J. Identification of key genes and pathways in myeloma side population cells by bioinformatics analysis. Int J Med Sci. 2020;17(14):2063–76.
Article
CAS
PubMed
PubMed Central
Google Scholar
Herb M, Gluschko A, Schramm M. LC3-associated phagocytosis initiated by integrin ITGAM-ITGB2/Mac-1 enhances immunity to Listeria monocytogenes. Autophagy. 2018;14(8):1462–4.
Article
CAS
PubMed
PubMed Central
Google Scholar
Blight BJ, Gill AS, Sumsion JS, Pollard CE, Ashby S, Oakley GM, Alt JA, Pulsipher A. Cell adhesion molecules are upregulated and may drive inflammation in chronic rhinosinusitis with nasal polyposis. J Asthma Allergy. 2021;14:585–93.
Article
PubMed
PubMed Central
Google Scholar
Ayala F, Dewar R, Kieran M, Kalluri R. Contribution of bone microenvironment to leukemogenesis and leukemia progression. Leukemia. 2009;23(12):2233–41.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mendez LM, Posey RR, Pandolfi PP. The interplay between the genetic and immune landscapes of AML: mechanisms and implications for risk stratification and therapy. Front Oncol. 2019;9:1162.
Article
PubMed
PubMed Central
Google Scholar
Bigley AB, Simpson RJ. NK cells and exercise: implications for cancer immunotherapy and survivorship. Discov Med. 2015;19(107):433–45.
PubMed
Google Scholar
Moretta L, Montaldo E, Vacca P, Del Zotto G, Moretta F, Merli P, Locatelli F, Mingari MC. Human natural killer cells: origin, receptors, function, and clinical applications. Int Arch Allergy Immunol. 2014;164(4):253–64.
Article
CAS
PubMed
Google Scholar
André P, Denis C, Soulas C, Bourbon-Caillet C, Lopez J, Arnoux T, Bléry M, Bonnafous C, Gauthier L, Morel A, et al. Anti-NKG2A mAb is a checkpoint inhibitor that promotes anti-tumor immunity by unleashing both T and NK cells. Cell. 2018;175(7):1731–43.
Article
PubMed
PubMed Central
CAS
Google Scholar
Borst L, van der Burg SH, van Hall T. The NKG2A–HLA-E axis as a novel checkpoint in the tumor microenvironment. Clin Cancer Res. 2020;26:5549–56.
Article
CAS
PubMed
Google Scholar
Haroun F, Solola SA, Nassereddine S, Tabbara I. PD-1 signaling and inhibition in AML and MDS. Ann Hematol. 2017;96(9):1441–8.
Article
CAS
PubMed
Google Scholar