Fig. 1

Cystoscopic, imaging, and pathological examination results and genomic sequencing in Case 1. a, b Cystoscopic findings in the urethra. The cystoscope shows several nodular polyps in the proximal penile urethra and distal bulbar urethra. c Prostate magnetic resonance imaging (MRI). The prostate was almost entirely replaced by the tumor, which has invaded the rectum. d MR image of the urethra. Metastases of the prostate cancer extended with skip lesions along the corpus spongiosum in the entire anterior urethra. e–h Representative microscopic images of hematoxylin and eosin (HE) staining and prostate-specific antigen and androgen receptor immunohistochemical staining of transurethral resections of urethra tumor specimens. These images were obtained using the following equipment: microscope, BX53; objective lens, UPLXAPO; camera, DP27; adapter, U-TV1XC. NanoZoomer-XR C12000 was used as acquisition software and the measured resolution was 500 dpi. i Examined genes (horizontal axis) and the copy number in Case 1 (vertical axis)