Fig. 4

Landscape of the somatic mutation profiles in original cervical cancer (F0), F2-PDX and F3-PDX models based on the whole-exome sequencing. A Bundled bar chart illustrating the top seven variant classifications. Green: missense mutation; Blue: frame shift del; Brown: in frame del; Red: nonsense mutation; Orange: splice site; Purple: frame shift ins; Dark red: in frame ins. The same annotation was applied in (B) and (C). B Histogram revealing the variants number in each sample. C Box plots showing the summary of variant classifications. The Y-axis represented the mean values with standard deviations of the somatic variant counts in original cervical cancer (F0), F2- and F3-PDX samples. D Bundled bar chart presenting the variant types. E Bundled bar chart displaying the single nucleotide variant (SNV) classifications. F Horizontal histogram exhibiting the top 10 mutated genes in all samples. The X-axis of (A), (D), (E), (F) and the Y-axis of (B) represented the somatic variant counts. SNP, single-nucleotide polymorphism. INS, insert. DEL, deletion. SNV, single-nucleotide variant