Table 2 The variant allele frequency (VAF) information of the representative mutations in patient original cervical cancer (F0) and cervical cancer PDX models (F2 and F3)
Gene-symbol | Variant type | cDNA | Amino acid | VAF | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
F0 | F2 | F3 | F0 | F2 | F3 | F0 | F2 | F3 | F0 | F2 | F3 | |
PLCB1 | SNP | c.1977C > G | p. D659E | 41.54% | 58.93% | 47.30% | ||||||
SNP | c.2438C > G | p. P813R | 35.09% | 42.86% | 41.51% | |||||||
KMT2D | SNP | c.4129C > T | p. Q1377* | 25.00% | 26.92% | 37.50% | ||||||
LRP1B | SNP | c.6688G > C | p. D2230H | 26.67% | 33.33% | 40.00% | ||||||
NAV3 | DEL | c.6134del | p. N2045Tfs*7 | 23.53% | 52.63% | 44.44% | ||||||
TP53 | SNP | c.796G > T | p. G266* | 69.57% | 100.00% | 100.00% | ||||||
MKI67 | SNP | c.7774G > C | p. E2592Q | 61.90% | 96.55% | 100.00% | ||||||
FAT1 | SNP | c.9472C > T | p. R3158W | 51.61% | 97.22% | 100.00% | ||||||
PKHD1L1 | SNP | c.5986G > C | p. E1996Q | 18.42% | 29.58% | 29.73% | ||||||
SPAG17 | SNP | c.1314G > C | p. E438D | 31.82% | 42.86% | 57.14% | ||||||
KIAA1109 | SNP | c.763G > T | p. E255* | 72.41% | 92.31% | 100.00% | ||||||