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Table 2 The variant allele frequency (VAF) information of the representative mutations in patient original cervical cancer (F0) and cervical cancer PDX models (F2 and F3)

From: Establishment and genetically characterization of patient-derived xenograft models of cervical cancer

Gene-symbol Variant type cDNA Amino acid VAF
F0 F2 F3 F0 F2 F3 F0 F2 F3 F0 F2 F3
PLCB1 SNP c.1977C > G p. D659E 41.54% 58.93% 47.30%
SNP c.2438C > G p. P813R 35.09% 42.86% 41.51%
KMT2D SNP c.4129C > T p. Q1377* 25.00% 26.92% 37.50%
LRP1B SNP c.6688G > C p. D2230H 26.67% 33.33% 40.00%
NAV3 DEL c.6134del p. N2045Tfs*7 23.53% 52.63% 44.44%
TP53 SNP c.796G > T p. G266* 69.57% 100.00% 100.00%
MKI67 SNP c.7774G > C p. E2592Q 61.90% 96.55% 100.00%
FAT1 SNP c.9472C > T p. R3158W 51.61% 97.22% 100.00%
PKHD1L1 SNP c.5986G > C p. E1996Q 18.42% 29.58% 29.73%
SPAG17 SNP c.1314G > C p. E438D 31.82% 42.86% 57.14%
KIAA1109 SNP c.763G > T p. E255* 72.41% 92.31% 100.00%