Table 2 Panels for hereditary tumor syndromes
Panel | Lab | List of genes | Cohort |
|---|---|---|---|
Hereditary breast and ovarian cancer | |||
BRCA standard | Genetica, KSA, HUG or Valais | BRCA1 and BRCA2 | BRCA1/2 = 1 |
BRCA plus Mamma/Breast cancer panel | Genetica, KSA | BRCA1, BRCA2, ATM, CDH1, CHEK2, PALB2, PTEN, STK11, TP53 | BRCA plus ≤ 10 genes = 2 |
BRCA plus Ovar/Ovarian cancer panel | Genetica, KSA | BRCA1, BRCA2, BRIP1, EPCAM (3’UTR), MLH1, MSH2, MSH6, PMS2, RAD51C, RAD51D | 2 |
Customized |  | BRCA plus ≤ 10 | 2 |
BRCA plus Lynch | Genetica, KSA | BRCA1, BRCA2, EPCAM (3'UTR), MLH1, MSH2, MSH6, PMS2 | 2 |
BRCA plus MMR genes | KSA | BRCA1, BRCA2 MLH1, MSH2, MSH6 and PMS2 | 2 |
BRCA plus HBOC | Genetica | BRCA1, BRCA2, ATM, BARD1, BRIP1, CDH1, CHEK2, EPCAM (3'UTR), MLH1, MSH2, MSH6, PALB2, PMS2, PTEN, RAD51C, RAD51D, STK11, TP53 | BRCA plus > 10 genes = 3 |
Extended breast- and ovarian cancer panel | KSA | BRCA1, BRCA2, ATM, BARD1, BLM, BRIP1, CDH1, CHEK2, EPCAM, FAM175A, MEN1, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, PTEN, RAD50, RAD51C, RAD51D, STK11, TP53, XRCC2 | 3 |
Customized |  | BRCA plus > 10 genes | 3 |
Lynch syndrome | |||
MMR genes | Basel | MLH1, MSH2, MSH6 and PMS2 | 4 |