Table 2 Univariate analysis of the relationship between TP and SNP alleles in olanzapine and aprepitant group at each stage

HTR3A

rs1062613

CC

15/15

9/15

9/15

19/19

14/19

14/19

Non-CC

13/13

8/13

8/13

10/11

1/11

1/11

P

1.000

1.000

1.000

0.367

0.002

0.002

rs1176719

GG

61/63

36/63

36/63

63/69

37/69

37/69

Non-GG

17/30

27/30

17/30

24/25

17/25

17/25

P

0.000

0.002

0.002

0.748

0.245

0.245

rs1176722

GG

75/79

46/79

46/79

79/85

50/85

50/85

Non-GG

13/14

7/14

7/14

8/9

4/9

4/9

P

0.566

0.771

0.771

0.518

0.635

0.635

rs909411

GG

66/69

40/69

40/69

70/76

42/76

72/76

Non-GG

22/24

13/24

13/24

17/18

12/18

12/18

P

0.826

0.813

0.813

1.000

0.436

0.436

rs1176713

AA

59/62

36/62

36/62

58/63

35/63

35/63

Non-AA

29/32

17/32

17/32

31/33

20/33

20/33

P

0.684

0.667

0.667

1.000

0.670

0.670

rs2276303

GG

73/75

43/75

43/75

75/82

44/82

44/82

Non-GG

15/19

10/19

10/19

14/14

11/14

11/14

P

0.016

0.798

0.798

0.562

0.142

0.142

HTR3B

rs2276305

GG

62/66

37/66

37/66

51/56

28/56

28/56

Non-GG

26/27

16/27

16/27

36/38

26/38

26/38

P

1.000

0.821

0.821

0.792

0.092

0.092

rs4938058

AA

53/55

32/55

32/55

49/53

31/53

31/53

Non-AA

35/38

21/38

21/38

35/37

21/37

21/37

P

0.669

0.833

0.833

1.000

1.000

1.000

rs1176744

AA

50/53

29/53

29/53

49/53

30/53

30/53

Non-AA

36/39

22/39

22/39

39/42

24/42

24/42

P

1.000

1.000

1.000

1.000

1.000

1.000

rs12795805

TT

51/54

29/54

29/54

51/55

31/55

31/55

Non-TT

37/40

24/40

24/40

38/41

24/41

24/41

P

1.000

0.674

0.674

1.000

0.838

0.838

rs3758987

TT

48/51

29/51

29/51

51/53

32/53

32/53

Non-TT

40/43

24/43

24/43

38/43

23/43

23/43

P

1.000

0.180

0.180

0.281

0.538

0.538

Variants (del/del+del/ins)

19/19

10/19

10/19

29/31

13/31

13/31

Wild type (ins/ins)

68/73

43/73

43/73

60/65

42/65

42/65

P

0.545

0.795

0.795

1.000

0.047

0.047

rs7943062

GG

65/69

42/69

42/69

71/76

49/76

49/76

Non-GG

23/25

11/25

11/25

18/20

6/20

6/20

P

1.000

0.164

0.164

0.968

0.010

0.010

HTR3C

rs6766410

CC

13/14

6/14

6/14

9/11

2/11

2/11

Non-CC

75/79

47/79

47/79

78/83

52/83

52/83

P

0.566

0.380

0.380

0.189

0.013

0.013

HTR3D

rs6443930

CC

22/25

13/25

13/25

27/29

20/29

20/29

Non-CC

66/69

40/69

40/69

61/66

35/66

35/66

P

0.388

0.644

0.644

1.000

0.179

0.179

Serotonin transporter Promoter

rs956304

TT

63/65

44/65

44/65

64/69

42/69

42/69

Non-TT

1/2

0/2

0/2

4/4

1/4

1/4

P

0.088

0.114

0.114

1.000

0.371

0.371

ERCC1

rs11615

GG

70/74

42/74

42/74

55/59

33/59

33/59

Non-GG

18/19

11/19

11/19

32/35

21/35

21/35

P

1.000

1.000

1.000

1.000

1.000

1.000

rs3212986

CC

37/37

27/37

27/37

50/52

32/52

32/52

Non-CC

51/56

26/56

26/56

37/42

22/42

22/42

P

0.162

0.018

0.018

0.278

0.407

0.407

ERCC4

rs25487

CC

51/53

27/53

27/53

51/54

29/54

29/54

Non-CC

37/40

26/40

26/40

36/40

25/40

25/40

P

0.746

0.208

0.208

0.679

0.409

0.409

rs744154

CC

11/12

2/12

2/12

1/1

1/1

1/1

Non-CC

76/80

51/80

51/80

88/95

54/95

54/95

P

0.511

0.003

0.003

1.000

1.000

1.000

MTHFR

rs1801131

TT

60/63

37/63

37/63

63/65

43/65

43/65

Non-TT

27/29

15/29

15/29

21/26

8/26

8/26

P

1.000

0.651

0.651

0.029

0.003

0.003

rs1801133

AA

28/29

17/29

17/29

23/23

16/23

16/23

Non-AA

60/65

36/65

36/65

66/73

39/73

39/73

P

0.748

0.825

0.825

0.279

0.229

0.229

ABCG2

rs2231142

GG

47/50

28/50

28/50

44/47

26/47

26/47

Non-GG

41/43

25/43

25/43

43/47

28/47

28/47

P

1.000

1.000

1.000

1.000

0.327

0.327

rs2238476

GG

76/80

45/80

45/80

78/85

49/85

49/85

Non-GG

12/13

8/13

8/13

9/9

5/9

5/9

P

0.374

0.772

0.772

1.000

1.000

1.000

rs246240

AA

28/28

15/28

15/28

29/32

18/32

18/32

Non-AA

60/65

38/65

38/65

58/62

36/62

36/62

P

0.314

0.820

0.820

0.923

1.000

1.000

rs2231137

CC

35/37

21/37

21/37

44/49

28/49

28/49

Non-CC

53/57

32/57

32/57

45/47

27/47

27/47

P

1.000

1.000

1.000

0.467

1.000

1.000

FAS / CD95

rs2234978

CC

81/85

49/85

49/85

75/81

49/81

49/81

Non-CC

7/8

4/8

4/8

12/13

5/13

5/13

P

0.369

0.965

0.965

1.000

0.226

0.226

CCL2

rs2530797

TT

48/50

28/50

28/50

40/43

26/43

26/43

Non-TT

40/43

25/43

25/43

47/51

28/51

28/51

P

0.862

1.000

1.000

1.000

0.677

0.677

TACR1

rs3755468

CC

23/25

15/25

15/25

9/9

5/9

5/9

Non-CC

61/63

36/63

36/63

75/82

46/82

46/82

P

0.680

0.155

0.155

1.000

1.000

1.000

rs3771836

TT

45/45

30/45

30/45

50/54

32/54

32/54

Non-TT

43/48

23/48

23/48

37/40

22/40

22/40

P

0.077

0.094

0.094

1.000

0.833

0.833

rs17838409

CC

84/89

53/89

53/89

89/95

55/95

55/95

Non-CC

4/5

0/5

0/5

0/1

0/1

0/1

P

0.286

0.014

0.014

0.294

0.427

0.427

rs2111375

GG

46/48

26/48

26/48

53/58

31/58

31/58

Non-GG

42/46

27/46

27/46

36/38

24/38

24/38

P

0.634

0.683

0.683

0.828

0.402

0.402

rs3821313

GG

60/62

39/62

39/62

66/73

41/73

41/73

Non-GG

20/24

8/24

8/24

20/20

11/20

11/20

P

0.085

0.017

0.017

0.336

1.000

1.000

rs6715729

AA

24/27

16/27

16/27

21/23

12/23

12/23

Non-AA

64/67

37/67

37/67

68/73

43/73

43/73

P

0.469

0.820

0.820

1.000

0.633

0.633

CYP2D6

rs16947

GG

54/57

36/57

36/57

58/60

35/60

35/60

Non-GG

34/37

17/37

17/37

31/36

20/36

20/36

P

0.905

0.136

0.136

0.128

0.833

0.833

ALDH2

rs671

GG

66/70

39/70

39/70

61/65

39/65

39/65

Non-GG

21/22

14/22

14/22

24/26

15/26

15/26

P

1.000

0.623

0.623

1.000

1.000

1.000

ATP7B

rs1801244

CC

29/31

19/31

19/31

36/37

24/37

24/37

Non-CC

59/63

34/63

34/63

53/59

31/59

31/59

P

1

0.517

0.517

0.334

0.291

0.291