Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116(2):281–97.
Article
CAS
PubMed
Google Scholar
Urbich C, Kuehbacher A, Dimmeler S. Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc Res. 2008;79(4):581–8. doi:10.1093/cvr/cvn156.
Article
CAS
PubMed
Google Scholar
Vickers KC, Palmisano BT, Shoucri BM, Shamburek RD, Remaley AT. MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol. 2011;13(4):423–33. doi:10.1038/ncb2210.
Article
PubMed Central
CAS
PubMed
Google Scholar
Chen X, Liang H, Zhang J, Zen K, Zhang CY. Secreted microRNAs: a new form of intercellular communication. Trends Cell Biol. 2012;22(3):125–32. doi:10.1016/j.tcb.2011.12.001.
Article
CAS
PubMed
Google Scholar
De Guire V, Robitaille R, Tetreault N, Guerin R, Menard C, Bambace N, et al. Circulating miRNAs as sensitive and specific biomarkers for the diagnosis and monitoring of human diseases: promises and challenges. Clin Biochem. 2013;46(10-11):846–60. doi:10.1016/j.clinbiochem.2013.03.015.
Article
PubMed
Google Scholar
Keller A, Leidinger P, Bauer A, Elsharawy A, Haas J, Backes C, et al. Toward the blood-borne miRNome of human diseases. Nat Methods. 2011;8(10):841–3. doi:10.1038/nmeth.1682.
Article
CAS
PubMed
Google Scholar
Pescador N, Perez-Barba M, Ibarra JM, Corbaton A, Martinez-Larrad MT, Serrano-Rios M. Serum circulating microRNA profiling for identification of potential type 2 diabetes and obesity biomarkers. PLoS One. 2013;8(10):e77251. doi:10.1371/journal.pone.0077251.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zampetaki A, Willeit P, Tilling L, Drozdov I, Prokopi M, Renard JM, et al. Prospective study on circulating MicroRNAs and risk of myocardial infarction. J Am Coll Cardiol. 2012;60(4):290–9. doi:10.1016/j.jacc.2012.03.056.
Article
CAS
PubMed
Google Scholar
Keller A, Leidinger P, Vogel B, Backes C, ElSharawy A, Galata V, et al. miRNAs can be generally associated with human pathologies as exemplified for miR-144. BMC Med. 2014;12(1):224. doi:10.1186/s12916-014-0224-0.
Article
PubMed Central
PubMed
Google Scholar
Beyer C, Zampetaki A, Lin NY, Kleyer A, Perricone C, Iagnocco A, et al. Signature of circulating microRNAs in osteoarthritis. Ann Rheum Dis. 2015;74(3):e18. doi:10.1136/annrheumdis-2013-204698.
Article
PubMed
Google Scholar
Nair VS, Pritchard CC, Tewari M, Ioannidis JP. Design and Analysis for Studying microRNAs in Human Disease: A Primer on -Omic Technologies. Am J Epidemiol. 2014;180(2):140–52. doi:10.1093/aje/kwu135.
Article
PubMed Central
PubMed
Google Scholar
Hooten NN, Fitzpatrick M, Wood WH, De S, Ejiogu N, Zhang YQ, et al. Age-related changes in microRNA levels in serum. Aging-Us. 2013;5(10):725–40.
Google Scholar
Olivieri F, Spazzafumo L, Santini G, Lazzarini R, Albertini MC, Rippo MR, et al. Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging. Mech Ageing Dev. 2012;133(11-12):675–85. doi:10.1016/j.mad.2012.09.004.
Article
CAS
PubMed
Google Scholar
Meder B, Backes C, Haas J, Leidinger P, Stahler C, Grossmann T, et al. Influence of the confounding factors age and sex on microRNA profiles from peripheral blood. Clin Chem. 2014;60(9):1200–8. doi:10.1373/clinchem.2014.224238.
Article
CAS
PubMed
Google Scholar
Mestdagh P, Hartmann N, Baeriswyl L, Andreasen D, Bernard N, Chen C, et al. Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) study. Nat Methods. 2014;11(8):809–15. doi:10.1038/nmeth.3014.
Article
CAS
PubMed
Google Scholar
Volzke H, Alte D, Schmidt CO, Radke D, Lorbeer R, Friedrich N, et al. Cohort profile: the study of health in Pomerania. Int J Epidemiol. 2011;40(2):294–307. doi:10.1093/ije/dyp394.
Article
PubMed
Google Scholar
Lefever S, Hellemans J, Pattyn F, Przybylski DR, Taylor C, Geurts R, et al. RDML: structured language and reporting guidelines for real-time quantitative PCR data. Nucleic Acids Res. 2009;37(7):2065–9. doi:10.1093/nar/gkp056.
Article
PubMed Central
CAS
PubMed
Google Scholar
R-Core-Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. 2014. http://www.R-project.org/.
Zhou X, Zhu W, Li H, Wen W, Cheng W, Wang F, et al. Diagnostic value of a plasma microRNA signature in gastric cancer: a microRNA expression analysis. Sci Rep. 2015;5:11251. doi:10.1038/srep11251.
Article
PubMed Central
CAS
PubMed
Google Scholar
Starikova I, Jamaly S, Sorrentino A, Blondal T, Latysheva N, Sovershaev M, et al. Differential expression of plasma miRNAs in patients with unprovoked venous thromboembolism and healthy control individuals. Thromb Res. 2015;136(3):566–72. doi:10.1016/j.thromres.2015.07.005.
Article
CAS
PubMed
Google Scholar
Zou H, Hastie T. Regularization and variable selection via the elastic net. J R Statist Soc B. 2005;67(2):301–20. doi:10.1111/j.1467-9868.2005.00503.x.
Article
Google Scholar
Friedman J, Hastie T, Tibshirani R. Regularization Paths for Generalized Linear Models via Coordinate Descent. J Stat Softw. 2010;33(1):1–22.
Article
PubMed Central
PubMed
Google Scholar
Cheng HH, Yi HS, Kim Y, Kroh EM, Chien JW, Eaton KD, et al. Plasma processing conditions substantially influence circulating microRNA biomarker levels. PLoS One. 2013;8(6):e64795. doi:10.1371/journal.pone.0064795.
Article
PubMed Central
CAS
PubMed
Google Scholar
Pritchard CC, Kroh E, Wood B, Arroyo JD, Dougherty KJ, Miyaji MM, et al. Blood cell origin of circulating microRNAs: a cautionary note for cancer biomarker studies. Cancer Prev Res (Phila). 2012;5(3):492–7. doi:10.1158/1940-6207.CAPR-11-0370.
Article
CAS
Google Scholar
Olivieri F, Bonafe M, Spazzafumo L, Gobbi M, Prattichizzo F, Recchioni R, et al. Age- and glycemia-related miR-126-3p levels in plasma and endothelial cells. Aging. 2014;6(9):771–87.
PubMed Central
CAS
PubMed
Google Scholar
Hatse S, Brouwers B, Dalmasso B, Laenen A, Kenis C, Schoffski P, et al. Circulating MicroRNAs as easy-to-measure aging biomarkers in older breast cancer patients: correlation with chronological age but not with fitness/frailty status. PLoS One. 2014;9(10):e110644. doi:10.1371/journal.pone.0110644.
Article
PubMed Central
PubMed
Google Scholar
Park S, Kang S, Min KH, Woo Hwang K, Min H. Age-associated changes in microRNA expression in bone marrow derived dendritic cells. Immunol Investig. 2013;42(3):179–90. doi:10.3109/08820139.2012.717328.
Article
CAS
Google Scholar
Hackl M, Brunner S, Fortschegger K, Schreiner C, Micutkova L, Muck C, et al. miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging. Aging Cell. 2010;9(2):291–6. doi:10.1111/j.1474-9726.2010.00549.x.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bandiera S, Pfeffer S, Baumert TF, Zeisel MB. miR-122--a key factor and therapeutic target in liver disease. J Hepatol. 2015;62(2):448–57. doi:10.1016/j.jhep.2014.10.004.
Article
CAS
PubMed
Google Scholar
Peng Y, Yu S, Li H, Xiang H, Peng J, Jiang S. MicroRNAs: emerging roles in adipogenesis and obesity. Cell Signal. 2014;26(9):1888–96. doi:10.1016/j.cellsig.2014.05.006.
Article
CAS
PubMed
Google Scholar
Starkey Lewis PJ, Dear J, Platt V, Simpson KJ, Craig DG, Antoine DJ, et al. Circulating microRNAs as potential markers of human drug-induced liver injury. Hepatology. 2011;54(5):1767–76. doi:10.1002/hep.24538.
Article
CAS
PubMed
Google Scholar
Waidmann O, Bihrer V, Pleli T, Farnik H, Berger A, Zeuzem S, et al. Serum microRNA-122 levels in different groups of patients with chronic hepatitis B virus infection. J Viral Hepat. 2012;19(2):e58–65. doi:10.1111/j.1365-2893.2011.01536.x.
Article
CAS
PubMed
Google Scholar
van der Meer AJ, Farid WR, Sonneveld MJ, de Ruiter PE, Boonstra A, van Vuuren AJ, et al. Sensitive detection of hepatocellular injury in chronic hepatitis C patients with circulating hepatocyte-derived microRNA-122. J Viral Hepat. 2013;20(3):158–66. doi:10.1111/jvh.12001.
Article
PubMed
Google Scholar
Tan Y, Ge G, Pan T, Wen D, Gan J. A pilot study of serum microRNAs panel as potential biomarkers for diagnosis of nonalcoholic fatty liver disease. PLoS One. 2014;9(8):e105192. doi:10.1371/journal.pone.0105192.
Article
PubMed Central
PubMed
Google Scholar
Girard M, Jacquemin E, Munnich A, Lyonnet S, Henrion-Caude A. miR-122, a paradigm for the role of microRNAs in the liver. J Hepatol. 2008;48(4):648–56. doi:10.1016/j.jhep.2008.01.019.
Article
CAS
PubMed
Google Scholar
Teruel-Montoya R, Kong X, Abraham S, Ma L, Kunapuli SP, Holinstat M, et al. MicroRNA expression differences in human hematopoietic cell lineages enable regulated transgene expression. PLoS One. 2014;9(7):e102259. doi:10.1371/journal.pone.0102259.
Article
PubMed Central
PubMed
Google Scholar
Ambayya A, Su AT, Osman NH, Nik-Samsudin NR, Khalid K, Chang KM, et al. Haematological reference intervals in a multiethnic population. PLoS One. 2014;9(3):e91968. doi:10.1371/journal.pone.0091968.
Article
PubMed Central
PubMed
Google Scholar
Murphy WG. The sex difference in haemoglobin levels in adults - mechanisms, causes, and consequences. Blood Rev. 2014;28(2):41–7. doi:10.1016/j.blre.2013.12.003.
Article
CAS
PubMed
Google Scholar
Zimmerman AL, Wu S. MicroRNAs, cancer and cancer stem cells. Cancer Lett. 2011;300(1):10–9. doi:10.1016/j.canlet.2010.09.019.
Article
PubMed Central
CAS
PubMed
Google Scholar
Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, et al. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell. 2007;129(7):1401–14. doi:10.1016/j.cell.2007.04.040.
Article
PubMed Central
CAS
PubMed
Google Scholar
Dai R, Ahmed SA. Sexual dimorphism of miRNA expression: a new perspective in understanding the sex bias of autoimmune diseases. Ther Clin Risk Manag. 2014;10:151–63. doi:10.2147/TCRM.S33517.
PubMed Central
CAS
PubMed
Google Scholar