Ogden CL, Fryar CD, Martin CB, Freedman DS, Carroll MD, Gu Q, Hales CM. Trends in obesity prevalence by race and hispanic origin—1999-2000 to 2017–2018. JAMA. 2020;324(12):1208–10.
Article
PubMed
PubMed Central
Google Scholar
Kahn BB, Flier JS. Obesity and insulin resistance. J Clin Investig. 2000;106(4):473–81.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pausova Z. From big fat cells to high blood pressure: a pathway to obesity-associated hypertension. Curr Opin Nephrol Hypertens. 2006;15(2):173–8.
Article
PubMed
Google Scholar
Franssen R, Monajemi H, Stroes ES, Kastelein JJ. Obesity and dyslipidemia. Med Clin North Am. 2011;95(5):893–902.
Article
CAS
PubMed
Google Scholar
Chikunguwo S, Brethauer S, Nirujogi V, Pitt T, Udomsawaengsup S, Chand B, Schauer P. Influence of obesity and surgical weight loss on thyroid hormone levels. Surg Obesity Related Dis. 2007;3(6):631–5.
Article
Google Scholar
Schmidt MI, Watson RL, Duncan BB, Metcalf P, Brancati FL, Sharrett AR, Davis C, Heiss G. Investigators ARiCS: Clustering of dyslipidemia, hyperuricemia, diabetes, and hypertension and its association with fasting insulin and central and overall obesity in a general population. Metabolism. 1996;45(6):699–706.
Article
CAS
PubMed
Google Scholar
Jafar TH, Chaturvedi N, Pappas G. Prevalence of overweight and obesity and their association with hypertension and diabetes mellitus in an Indo-Asian population. CMAJ. 2006;175(9):1071–7.
Article
PubMed
PubMed Central
Google Scholar
Koh EH, Kim A-R, Kim H, Kim JH, Park H-S, Ko MS, Kim M-O, Kim H-J, Kim BJ, Yoo HJ. 11b-HSD1 reduces metabolic efficacy and adiponectin synthesis in hypertrophic adipocytes. J Endocrinol. 2015;225:147–58.
Article
CAS
PubMed
Google Scholar
Gustafson B. Adipose tissue, inflammation and atherosclerosis. J Atheroscler Thromb. 2010;17(4):332–41.
Article
CAS
PubMed
Google Scholar
Blackburn P, Després JP, Lamarche B, Tremblay A, Bergeron J, Lemieux I, Couillard C. Postprandial variations of plasma inflammatory markers in abdominally obese men. Obesity. 2006;14(10):1747–54.
Article
CAS
PubMed
Google Scholar
Abeywardena MY, Leifert WR, Warnes KE, Varghese JN, Head RJ. Cardiovascular biology of interleukin-6. Curr Pharm Des. 2009;15(15):1809–21.
Article
CAS
PubMed
Google Scholar
Wang A, Liu J, Li C, Gao J, Li X, Chen S, Wu S, Ding H, Fan H, Hou S. Cumulative exposure to high-sensitivity C-reactive protein predicts the risk of cardiovascular disease. J Am Heart Assoc. 2017;6(10):e005610.
Article
PubMed
PubMed Central
Google Scholar
Tajfard M, Tavakoly Sany SB, Avan A, Latiff LA, Rahimi HR, Moohebati M, Hasanzadeh M, Ghazizadeh H, Esmaeily H, Doosti H. Relationship between serum high sensitivity C-reactive protein with angiographic severity of coronary artery disease and traditional cardiovascular risk factors. J Cell Physiol. 2019;234(7):10289–99.
Article
CAS
PubMed
Google Scholar
Fu Y, Wu Y, Liu E. C-reactive protein and cardiovascular disease: From animal studies to the clinic. Exp Ther Med. 2020;20(2):1211–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Reilly SM, Saltiel AR. Adapting to obesity with adipose tissue inflammation. Nat Rev Endocrinol. 2017;13(11):633–43.
Article
CAS
PubMed
Google Scholar
Barzilay J, Forsberg C, Heckbert S, Cushman M, Newman A. The association of markers of inflammation with weight change in older adults: the Cardiovascular Health Study. Int J Obes. 2006;30(9):1362–7.
Article
CAS
Google Scholar
Park EJ, Lee JH, Yu G-Y, He G, Ali SR, Holzer RG, Österreicher CH, Takahashi H, Karin M. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell. 2010;140(2):197–208.
Article
CAS
PubMed
PubMed Central
Google Scholar
Soukas A, Cohen P, Socci ND, Friedman JM. Leptin-specific patterns of gene expression in white adipose tissue. Genes Dev. 2000;14(8):963–80.
Article
CAS
PubMed
PubMed Central
Google Scholar
Way JM, Harrington WW, Brown KK, Gottschalk WK, Sundseth SS, Mansfield TA, Ramachandran RK, Willson TM, Kliewer SA. Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor γ activation has coordinate effects on gene expression in multiple insulin-sensitive tissues. Endocrinology. 2001;142(3):1269–77.
Article
CAS
PubMed
Google Scholar
Gratten J, Visscher PM. Genetic pleiotropy in complex traits and diseases: implications for genomic medicine. Genome Med. 2016;8(1):1–3.
Article
CAS
Google Scholar
Stearns FW. One hundred years of pleiotropy: a retrospective. Genetics. 2010;186(3):767–73.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kraja AT, Chasman DI, North KE, Reiner AP, Yanek LR, Kilpeläinen TO, Smith JA, Dehghan A, Dupuis J, Johnson AD. Pleiotropic genes for metabolic syndrome and inflammation. Mol Genet Metab. 2014;112(4):317–38.
Article
CAS
PubMed
PubMed Central
Google Scholar
Swenson BR, Louie T, Lin HJ, Méndez-Giráldez R, Below JE, Laurie CC, Kerr KF, Highland H, Thornton TA, Ryckman KK. GWAS of QRS duration identifies new loci specific to Hispanic/Latino populations. PLoS ONE. 2019;14(6): e0217796.
Article
CAS
PubMed
PubMed Central
Google Scholar
Schick UM, Jain D, Hodonsky CJ, Morrison JV, Davis JP, Brown L, Sofer T, Conomos MP, Schurmann C, McHugh CP. Genome-wide association study of platelet count identifies ancestry-specific loci in Hispanic/Latino Americans. Am J Human Genet. 2016;98(2):229–42.
Article
CAS
Google Scholar
Khan UI, Wang D, Sowers MR, Mancuso P, Everson-Rose SA, Scherer PE, Wildman RP. Race–ethnic differences in adipokine levels: the Study of Women’s Health Across the Nation (SWAN). Metabolism. 2012;61(9):1261–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Morimoto Y, Conroy SM, Ollberding NJ, Kim Y, Lim U, Cooney RV, Franke AA, Wilkens LR, Hernandez BY, Goodman MT. Ethnic differences in serum adipokine and C-reactive protein levels: the multiethnic cohort. Int J Obes. 2014;38(11):1416–22.
Article
CAS
Google Scholar
Nazare J-A, Smith JD, Borel A-L, Haffner SM, Balkau B, Ross R, Massien C, Almeras N, Despres J-P. Ethnic influences on the relations between abdominal subcutaneous and visceral adiposity, liver fat, and cardiometabolic risk profile: the International Study of Prediction of Intra-Abdominal Adiposity and Its Relationship With Cardiometabolic Risk/Intra-Abdominal Adiposity. Am J Clin Nutr. 2012;96(4):714–26.
Article
CAS
PubMed
Google Scholar
Lê K-A, Ventura EE, Fisher JQ, Davis JN, Weigensberg MJ, Punyanitya M, Hu HH, Nayak KS, Goran MI. Ethnic differences in pancreatic fat accumulation and its relationship with other fat depots and inflammatory markers. Diabetes Care. 2011;34(2):485–90.
Article
PubMed
PubMed Central
CAS
Google Scholar
Frank AT, Zhao B, Jose PO, Azar KM, Fortmann SP, Palaniappan LP. Racial/ethnic differences in dyslipidemia patterns. Circulation. 2014;129(5):570–9.
Article
CAS
PubMed
Google Scholar
Kim J, Bai Y, Pan W. An adaptive association test for multiple phenotypes with GWAS summary statistics. Genet Epidemiol. 2015;39(8):651–63.
Article
PubMed
PubMed Central
Google Scholar
Manolio TA: Collaborative genome-wide association studies of diverse diseases: programs of the NHGRI’s office of population genomics. 2009.
Kenny EM. Population Architecture using Genomics and Epidemiology (PAGE).
Matise TC, Ambite JL, Buyske S, Carlson CS, Cole SA, Crawford DC, Haiman CA, Heiss G, Kooperberg C, Marchand LL. The Next PAGE in understanding complex traits: design for the analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study. Am J Epidemiol. 2011;174(7):849–59.
Article
PubMed
PubMed Central
Google Scholar
Fisher-Hoch SP, Rentfro AR, Wilson JG, Salinas JJ, Reininger BM, Restrepo BI, McCormick JB, Pérez A, Brown HS, Hossain MM: Peer Reviewed: Socioeconomic Status and Prevalence of Obesity and Diabetes in a Mexican American Community, Cameron County, Texas, 2004–2007. Preventing chronic disease 2010, 7(3).
Gorber SC, Tremblay MS. The bias in self-reported obesity from 1976 to 2005: a Canada–US comparison. Obesity. 2010;18(2):354–61.
Article
Google Scholar
Carty CL, Bhattacharjee S, Haessler J, Cheng I, Hindorff LA, Aroda V, Carlson CS, Hsu C-N, Wilkens L, Liu S. Analysis of metabolic syndrome components in > 15 000 african americans identifies pleiotropic variants: results from the population architecture using genomics and epidemiology study. Circ Cardiovasc Genet. 2014;7(4):505–13.
Article
PubMed
PubMed Central
Google Scholar
Brooks GC, Blaha MJ, Blumenthal RS. Relation of C-reactive protein to abdominal adiposity. Am J Cardiol. 2010;106(1):56–61.
Article
CAS
PubMed
Google Scholar
Kocarnik JM, Pendergrass SA, Carty CL, Pankow JS, Schumacher FR, Cheng I, Durda P, Ambite JL, Deelman E, Cook NR. Multiancestral analysis of inflammation-related genetic variants and C-reactive protein in the population architecture using genomics and epidemiology study. Circ Cardiovasc Genet. 2014;7(2):178–88.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bien SA, Wojcik GL, Zubair N, Gignoux CR, Martin AR, Kocarnik JM, Martin LW, Buyske S, Haessler J, Walker RW. Strategies for enriching variant coverage in candidate disease loci on a multiethnic genotyping array. PLoS ONE. 2016;11(12):e0167758.
Article
PubMed
PubMed Central
CAS
Google Scholar
Hu Y, Bien SA, Nishimura KK, Haessler J, Hodonsky CJ, Baldassari AR, Highland HM, Wang Z, Preuss M, Sitlani CM. Multi-ethnic genome-wide association analyses of white blood cell and platelet traits in the Population Architecture using Genomics and Epidemiology (PAGE) study. BMC Genomics. 2021;22(1):1–11.
Google Scholar
Kowalski MH, Qian H, Hou Z, Rosen JD, Tapia AL, Shan Y, Jain D, Argos M, Arnett DK, Avery C. Use of> 100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations. PLoS Genet. 2019;15(12):e1008500.
Article
PubMed
PubMed Central
CAS
Google Scholar
Lin D-Y, Tao R, Kalsbeek WD, Zeng D, Gonzalez F II, Fernández-Rhodes L, Graff M, Koch GG, North KE, Heiss G. Genetic association analysis under complex survey sampling: the Hispanic Community Health Study/Study of Latinos. Am J Human Genet. 2014;95(6):675–88.
Article
CAS
Google Scholar
Willer CJ, Li Y, Abecasis GR. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics. 2010;26(17):2190–1.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hackinger S, Zeggini E. Statistical methods to detect pleiotropy in human complex traits. Open Biol. 2017;7(11):170125.
Article
PubMed
PubMed Central
Google Scholar
Schaid DJ, Tong X, Larrabee B, Kennedy RB, Poland GA, Sinnwell JP. Statistical methods for testing genetic pleiotropy. Genetics. 2016;204(2):483–97.
Article
PubMed
PubMed Central
Google Scholar
Geyer CJ. Practical markov chain monte carlo. Stat Sci. 1992;7:473–83.
Google Scholar
Fadista J, Manning AK, Florez JC, Groop L. The (in) famous GWAS P-value threshold revisited and updated for low-frequency variants. Eur J Hum Genet. 2016;24(8):1202–5.
Article
PubMed
PubMed Central
Google Scholar
Kamat MA, Blackshaw JA, Young R, Surendran P, Burgess S, Danesh J, Butterworth AS, Staley JR. PhenoScanner V2: an expanded tool for searching human genotype–phenotype associations. Bioinformatics. 2019;35(22):4851–3.
Article
CAS
PubMed
PubMed Central
Google Scholar
Welter D, MacArthur J, Morales J, Burdett T, Hall P, Junkins H, Klemm A, Flicek P, Manolio T, Hindorff L. The NHGRI GWAS Catalog, a curated resource of SNP-trait associations. Nucleic Acids Res. 2014;42(D1):D1001–6.
Article
CAS
PubMed
Google Scholar
Lonsdale J, Thomas J, Salvatore M, Phillips R, Lo E, Shad S, Hasz R, Walters G, Garcia F, Young N. The genotype-tissue expression (GTEx) project. Nat Genet. 2013;45(6):580–5.
Article
CAS
Google Scholar
Ward LD, Kellis M. HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res. 2012;40(D1):D930–4.
Article
CAS
PubMed
Google Scholar
Imai K, Keele L, Tingley D. A general approach to causal mediation analysis. Psychol Methods. 2010;15(4):309.
Article
PubMed
Google Scholar
Solovieff N, Cotsapas C, Lee PH, Purcell SM, Smoller JW. Pleiotropy in complex traits: challenges and strategies. Nat Rev Genet. 2013;14(7):483–95.
Article
CAS
PubMed
PubMed Central
Google Scholar
Torday JS. Pleiotropy, the physiologic basis for biologic fields. Prog Biophys Mol Biol. 2018;136:37–9.
Article
PubMed
Google Scholar
Imai K, Keele L, Tingley D, Yamamoto T. Causal mediation analysis using R. In: Advances in social science research using R. Springer; 2010: 129–154.
Zeileis A. Object-oriented computation of sandwich estimators. J Stat Softw. 2006;16:1–16.
Article
Google Scholar
Mammes O, Aubert R, Betoulle D, Pean F, Herbeth B, Visvikis S, Siest G, Fumeron F. LEPR gene polymorphisms: associations with overweight, fat mass and response to diet in women. Eur J Clin Invest. 2001;31(5):398–404.
Article
CAS
PubMed
Google Scholar
Gregoor JG, van der Weide J, Mulder H, Cohen D, van Megen HJ, Egberts AC, Heerdink ER. Polymorphisms of the LEP-and LEPR gene and obesity in patients using antipsychotic medication. J Clin Psychopharmacol. 2009;29(1):21–5.
Article
CAS
PubMed
Google Scholar
Marzi C. Is acute-phase serum amyloid a protein a risk factor for type 2 diabetes: epidemiologic perspective including a genetic approach. München, Ludwig-Maximilians-Universität, Diss., 2014; 2014.
Uhlar CM, Whitehead AS. Serum amyloid A, the major vertebrate acute-phase reactant. Eur J Biochem. 1999;265(2):501–23.
Article
CAS
PubMed
Google Scholar
Yang R-Z, Lee M-J, Hu H, Pollin TI, Ryan AS, Nicklas BJ, Snitker S, Horenstein RB, Hull K, Goldberg NH. Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications. PLoS Med. 2006;3(6):e287.
Article
PubMed
PubMed Central
CAS
Google Scholar
Kocarnik JM, Richard M, Graff M, Haessler J, Bien S, Carlson C, Carty CL, Reiner AP, Avery CL, Ballantyne CM. Discovery, fine-mapping, and conditional analyses of genetic variants associated with C-reactive protein in multiethnic populations using the Metabochip in the Population Architecture using Genomics and Epidemiology (PAGE) study. Hum Mol Genet. 2018;27(16):2940–53.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hubacek JA, Peasey A, Pikhart H, Stavek P, Kubinova R, Marmot M, Bobak M. APOE polymorphism and its effect on plasma C-reactive protein levels in a large general population sample. Hum Immunol. 2010;71(3):304–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Long J, Liu P, Liu Y, Lu Y, Xiong D, Elze L, Recker R, Deng H. APOE and TGF-β1 genes are associated with obesity phenotypes. J Med Genet. 2003;40(12):918–24.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhao QR, Lei YY, Li J, Jiang N, Shi JP. Association between apolipoprotein E polymorphisms and premature coronary artery disease: a meta-analysis. Clin Chem Lab Med (CCLM). 2017;55(2):284–98.
Article
CAS
Google Scholar
Boulenouar H, Mediene BS, Ouhaibi DH, Larjam HS, Houti L, Hammani-Medjaoui I. Genetic variants on chromosome 19 (rs439401 and rs4420638) are associated with obesity and high blood pressure in the Algerian population. Baвилoвcкий жypнaл гeнeтики и ceлeкции. 2019;23(5):608–14.
Google Scholar
Iqbal Kring SI, Barefoot J, Brummett BH, Boyle SH, Siegler IC, Toubro S, Hansen T, Astrup A, Pedersen O, Williams RB. Associations between APOE variants and metabolic traits and the impact of psychological stress. PLoS ONE. 2011;6(1): e15745.
Article
CAS
PubMed
PubMed Central
Google Scholar
Prins BP, Kuchenbaecker KB, Bao Y, Smart M, Zabaneh D, Fatemifar G, Luan Ja, Wareham NJ, Scott RA, Perry JR. Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations. Sci Rep. 2017;7(1):1–9.
Article
CAS
Google Scholar
Belloy ME, Eger SJ, Guen YL, Napolioni V, Greicius MD. Initiative AsDN: Two APOE splice sQTLs reduce Alzheimer’s disease risk in APOE 4/4 carriers: genetics/genetic factors of Alzheimer’s disease. Alzheimers Dement. 2020;16:e043539.
Article
Google Scholar
Wang D, Zhang DF, Li GD, Bi R, Fan Y, Wu Y, Yu XF, Long H, Li YY, Yao YG. A pleiotropic effect of the APOE gene: association of APOE polymorphisms with multibacillary leprosy in Han Chinese from Southwest China. Br J Dermatol. 2018;178(4):931–9.
Article
CAS
PubMed
Google Scholar
Barter P. The inflammation: lipoprotein cycle. Atheroscler Suppl. 2005;6(2):15–20.
Article
CAS
PubMed
Google Scholar
Ligthart S, De Vries PS, Uitterlinden AG, Hofman A, Group CIW, Franco OH, Chasman DI, Dehghan A. Pleiotropy among common genetic loci identified for cardiometabolic disorders and C-reactive protein. PLoS ONE. 2015;10(3):e0118859.
Article
PubMed
PubMed Central
CAS
Google Scholar
Ligthart S, Vaez A, Hsu Y-H, Stolk R, Uitterlinden AG, Hofman A, Alizadeh BZ, Franco OH, Dehghan A. Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation. BMC Genomics. 2016;17(1):1–10.
Article
CAS
Google Scholar
Han L, Tang L, Wang C, Chen Z, Zhang T, Chen S, Liu S, Peng X, Mai Y, Duan S. Fat mass and obesity? associated gene rs11642015 polymorphism is significantly associated with prediabetes and type 2 diabetes subsequent to adjustment for body mass index. Biomed Rep. 2014;2(5):681–6.
Article
PubMed
PubMed Central
Google Scholar
Bryc K, Velez C, Karafet T, Moreno-Estrada A, Reynolds A, Auton A, Hammer M, Bustamante CD, Ostrer H. Genome-wide patterns of population structure and admixture among Hispanic/Latino populations. Proc Natl Acad Sci. 2010;107(supplement_2):8954–61.
Article
CAS
PubMed
PubMed Central
Google Scholar
Conomos MP, Laurie CA, Stilp AM, Gogarten SM, McHugh CP, Nelson SC, Sofer T, Fernández-Rhodes L, Justice AE, Graff M. Genetic diversity and association studies in US Hispanic/Latino populations: applications in the Hispanic Community Health Study/Study of Latinos. Am J Human Genet. 2016;98(1):165–84.
Article
CAS
Google Scholar
Consortium GP. An integrated map of genetic variation from 1,092 human genomes. Nature. 2012;491(7422):56–65.
Article
CAS
Google Scholar
van de Bunt M, Cortes A, Consortium I, Brown MA, Morris AP, McCarthy MI. Evaluating the performance of fine-mapping strategies at common variant GWAS loci. PLoS Genet. 2015;11(9):e1005535.
Article
PubMed
PubMed Central
CAS
Google Scholar
Kichaev G, Pasaniuc B. Leveraging functional-annotation data in trans-ethnic fine-mapping studies. Am J Human Genet. 2015;97(2):260–71.
Article
CAS
Google Scholar