Edited by Yuriy Orlov and Ancha Baranova.
Volume 12 Supplement 2
Selected articles from BGRS\SB-2018: medical genomics
Research
Publication of this supplement has not been supported by sponsorship. Information about the source of funding for publication charges can be found in the individual articles. The articles have undergone the journal's standard peer review process for supplements. YO is co-author of one of the articles and review of the article was handled entirely by AB. No other competing interests were declared.
Novosibirsk, Russia20-25 August 2018
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Citation: BMC Medical Genomics 2019 12(Suppl 2):36
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Exome, transcriptome and miRNA analysis don’t reveal any molecular markers of TKI efficacy in primary CML patients
Approximately 5–20% of chronic myeloid leukemia (CML) patients demonstrate primary resistance or intolerance to imatinib. None of the existing predictive scores gives a good prognosis of TKI efficacy. Gene pol...
Citation: BMC Medical Genomics 2019 12(Suppl 2):37 -
Transcriptome profiling analysis reveals that CXCL2 is involved in anlotinib resistance in human lung cancer cells
Anlotinib has been demonstrated its anti-tumor efficacy on non-small cell lung cancer (NSCLC) in clinical trials at 3rd line. However, anlotinib resistance occurs during its administration, and the underlying ...
Citation: BMC Medical Genomics 2019 12(Suppl 2):38 -
Mutational load in carotid body tumor
Carotid body tumor (CBT) is a rare neoplasm arising from paraganglion located near the bifurcation of the carotid artery. There is great intra-tumor heterogeneity, and CBT development could be associated with ...
Citation: BMC Medical Genomics 2019 12(Suppl 2):39 -
Clinical aspects of TP53 gene inactivation in diffuse large B-cell lymphoma
The knowledge about specific mechanisms generating TP53 dysfunction in diffuse large B-cell lymphoma is limited. The aim of the current study was to comprehensively explore TP53 gene variability resulting from so...
Citation: BMC Medical Genomics 2019 12(Suppl 2):35 -
Interrelation of chemerin and TNF-α with mtDNA copy number in adipose tissues and blood cells in obese patients with and without type 2 diabetes
Inflammatory response plays a key role in the development of insulin resistance (IR) in obesity. Oxidative stress triggers the replication of the mitochondrial genome and division of the organelle. The purpose...
Citation: BMC Medical Genomics 2019 12(Suppl 2):40 -
The relationship between the mtDNA copy number in insulin-dependent tissues and markers of endothelial dysfunction and inflammation in obese patients
Mitochondria play a central role in the regulation of energy metabolism, and the biogenesis of mitochondria is enhanced by the action of nitric oxide (NO), which is the key signaling molecule in the regulation...
Citation: BMC Medical Genomics 2019 12(Suppl 2):41 -
The role of long non-coding RNAs in the pathogenesis of hereditary diseases
Thousands of long non-coding RNA (lncRNA) genes are annotated in the human genome. Recent studies showed the key role of lncRNAs in a variety of fundamental cellular processes. Dysregulation of lncRNAs can dri...
Citation: BMC Medical Genomics 2019 12(Suppl 2):42 -
Genotype-phenotype correlations in FSHD
Facial-scapular-humeral myodystrophy Landouzy-Dejerine (FSHD) is an autosomal dominant disease, the basis of its pathogenesis is ectopic expression of the transcription factor DUX4 in skeletal muscle. There ar...
Citation: BMC Medical Genomics 2019 12(Suppl 2):43 -
Design and analysis of stably integrated reporters for inducible transgene expression in human T cells and CAR NK-cell lines
Cytotoxic activity of T- and NK-cells can be efficiently retargeted against cancer cells using chimeric antigen receptors (CARs) and rTCRs. In the context of solid cancers, use of armored CAR T- and NK cells s...
Citation: BMC Medical Genomics 2019 12(Suppl 2):44 -
The molecular mechanisms driving physiological changes after long duration space flights revealed by quantitative analysis of human blood proteins
The conditions of space flight have a significant effect on the physiological processes in the human body, yet the molecular mechanisms driving physiological changes remain unknown.
Citation: BMC Medical Genomics 2019 12(Suppl 2):45 -
FTO haplotyping underlines high obesity risk for European populations
Fat mass and obesity-associated (FTO) gene has been under close investigation since the discovery of its high impact on the obesity status in 2007 by a range of publications. Recent report on its implication in a...
Citation: BMC Medical Genomics 2019 12(Suppl 2):46 -
Prioritization of genes involved in endothelial cell apoptosis by their implication in lymphedema using an analysis of associative gene networks with ANDSystem
Currently, more than 150 million people worldwide suffer from lymphedema. It is a chronic progressive disease characterized by high-protein edema of various parts of the body due to defects in lymphatic draina...
Citation: BMC Medical Genomics 2019 12(Suppl 2):47 -
Immunohistochemical localization of NGF, BDNF, and their receptors in a normal and AMD-like rat retina
Age-related macular degeneration (AMD) is a major cause of blindness in developed countries, and the molecular pathogenesis of AMD is poorly understood. A large body of evidence has corroborated the key role o...
Citation: BMC Medical Genomics 2019 12(Suppl 2):48
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