Volume 6 Supplement 2

Selected articles from the Second Annual Translational Bioinformatics Conference (TBC 2012)


Edited by Ju Han Kim, Maricel Kann and Jessica Tenenbaum

Publication of this supplement has not been supported by any external sponsorship. Information about the funding for publication costs can be found in the Declarations section of each article.

Second Annual Translational Bioinformatics Conference (TBC 2012). Go to conference site.

Jeju Island, Korea

13-16 October 2012

  1. Research

    Analysis of small-sample clinical genomics studies using multi-parameter shrinkage: application to high-throughput RNA interference screening

    High-throughput (HT) RNA interference (RNAi) screens are increasingly used for reverse genetics and drug discovery. These experiments are laborious and costly, hence sample sizes are often very small. Powerful...

    Mark A van de Wiel, Renée X de Menezes, Ellen Siebring-van Olst and Victor W van Beusechem

    BMC Medical Genomics 2013 6(Suppl 2):S1

    Published on: 7 May 2013

  2. Research

    Compensating for literature annotation bias when predicting novel drug-disease relationships through Medical Subject Heading Over-representation Profile (MeSHOP) similarity

    Using annotations to the articles in MEDLINE®/PubMed®, over six thousand chemical compounds with pharmacological actions have been tracked since 1996. Medical Subject Heading Over-representation Profiles (MeSHOPs...

    Warren A Cheung, BF Francis Ouellette and Wyeth W Wasserman

    BMC Medical Genomics 2013 6(Suppl 2):S3

    Published on: 7 May 2013

  3. Research

    Curation-free biomodules mechanisms in prostate cancer predict recurrent disease

    Gene expression-based prostate cancer gene signatures of poor prognosis are hampered by lack of gene feature reproducibility and a lack of understandability of their function. Molecular pathway-level mechanism...

    James L Chen, Alexander Hsu, Xinan Yang, Jianrong Li, Younghee Lee, Gurunadh Parinandi, Haiquan Li and Yves A Lussier

    BMC Medical Genomics 2013 6(Suppl 2):S4

    Published on: 7 May 2013

  4. Research

    Diplotyper: diplotype-based association analysis

    It was previously reported that an association analysis based on haplotype clusters increased power over single-locus tests, and that another association test based on diplotype trend regression analysis outpe...

    Sunshin Kim, KyungChae Park, Chol Shin, Nam H Cho, Jeong-Jae Ko, InSong Koh and KyuBum Kwack

    BMC Medical Genomics 2013 6(Suppl 2):S5

    Published on: 7 May 2013

  5. Research

    BioBin: a bioinformatics tool for automating the binning of rare variants using publicly available biological knowledge

    With the recent decreasing cost of genome sequence data, there has been increasing interest in rare variants and methods to detect their association to disease. We developed BioBin, a flexible collapsing metho...

    Carrie B Moore, John R Wallace, Alex T Frase, Sarah A Pendergrass and Marylyn D Ritchie

    BMC Medical Genomics 2013 6(Suppl 2):S6

    Published on: 7 May 2013

  6. Research

    Identification of multiple gene-gene interactions for ordinal phenotypes

    Multifactor dimensionality reduction (MDR) is a powerful method for analysis of gene-gene interactions and has been successfully applied to many genetic studies of complex diseases. However, the main applicati...

    Kyunga Kim, Min-Seok Kwon, Sohee Oh and Taesung Park

    BMC Medical Genomics 2013 6(Suppl 2):S9

    Published on: 7 May 2013

  7. Research

    Integrative analysis of congenital muscular torticollis: from gene expression to clinical significance

    Congenital muscular torticollis (CMT) is characterized by thickening and/or tightness of the unilateral sternocleidomastoid muscle (SCM), ending up with torticollis. Our aim was to identify differentially expr...

    Shin-Young Yim, Dukyong Yoon, Myong Chul Park, Il Jae Lee, Jang-Hee Kim, Myung Ae Lee, Kyu-Sung Kwack, Jan-Dee Lee, Jeong-Hun Lee, Euy-Young Soh, Young-In Na, Rae Woong Park, KiYoung Lee and Jae-Bum Jun

    BMC Medical Genomics 2013 6(Suppl 2):S10

    Published on: 7 May 2013