Mossey PA, Little J, Munger RG, Dixon MJ, Shaw WC. Cleft lip and palate. Lancet. 2009;374(9703):1773–85.
Article
Google Scholar
Bender PL. Genetics of cleft lip and palate. J Pediatr Nurs. 2000;15(4):242–9.
Article
CAS
Google Scholar
Bezerra J, Oliveira G, Soares C, Cardoso M, Ururahy M, Neto F, Lima-Neto L, Luchessi A, Silbiger V, Fajardo C. Genetic and non-genetic factors that increase the risk of non-syndromic cleft lip and/or palate development. Oral Dis. 2015;21(3):393–9.
Article
CAS
Google Scholar
Richards L, Plachez C, Ren T. Developmental biology: Frontiers for clinical genetics. Section editors: Roderick R McInnes, e-mail: Jacques Michaud, e-mail:. Mechanisms regulating the development of the corpus callosum and its. Clin Genet. 2004;66(4):276–89.
Article
CAS
Google Scholar
Ghazali N, Rahman NA, Kannan TP, Jaafar S. Screening of transforming growth factor Beta 3 and Jagged2 genes in the Malay population with nonsyndromic cleft lip with or without cleft palate. Cleft Palate Craniofac J. 2015;52(4):e88–94.
Article
Google Scholar
do Rego Borges A, Sá J, Hoshi R, Viena CS, Mariano LC, de Castro Veiga P, Medrado AP, Machado RA, de Aquino SN, Messetti AC. Genetic risk factors for nonsyndromic cleft lip with or without cleft palate in a Brazilian population with high African ancestry. Am J Med Genet A. 2015;167(10):2344–9.
Article
Google Scholar
Jia P, Zhao Z. Network.Assisted analysis to prioritize GWAS results: principles, methods and perspectives. Hum Genet. 2014;133(2):125–38.
Article
CAS
Google Scholar
Wang L, Jia P, Wolfinger RD, Chen X, Zhao Z. Gene set analysis of genome-wide association studies: methodological issues and perspectives. Genomics. 2011;98(1):1–8.
Article
CAS
Google Scholar
Inui M, Martello G, Piccolo S. MicroRNA control of signal transduction. Nat Rev Mol Cell Biol. 2010;11(4):252–63.
Article
CAS
Google Scholar
Ross JS, Carlson JA, Brock G. miRNA: the new gene silencer. Am J Clin Pathol. 2007;128(5):830–6.
Article
CAS
Google Scholar
Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T. Identification of novel genes coding for small expressed RNAs. Science. 2001;294(5543):853–8.
Article
CAS
Google Scholar
Sun J, Gong X, Purow B, Zhao Z. Uncovering MicroRNA and transcription factor mediated regulatory networks in glioblastoma. PLoS Comput Biol. 2012;8(7):e1002488.
Article
CAS
Google Scholar
Jiang W, Mitra R, Lin CC, Wang Q, Cheng F, Zhao Z. Systematic dissection of dysregulated transcription factor-miRNA feed-forward loops across tumor types. Brief Bioinform. 2016;17(6):996–1008.
Article
CAS
Google Scholar
Schoen C, Aschrafi A, Thonissen M, Poelmans G, Von den Hoff JW, Carels CEL. MicroRNAs in Palatogenesis and cleft palate. Front Physiol. 2017;8:165.
Article
Google Scholar
Wang Q, Jia P, Cuenco KT, Zeng Z, Feingold E, Marazita ML, Wang L, Zhao Z. Association signals unveiled by a comprehensive gene set enrichment analysis of dental caries genome-wide association studies. PLoS One. 2013;8(8):e72653.
Article
CAS
Google Scholar
Sangani D, Suzuki A, VonVille H, Hixson JE, Iwata J. Gene mutations associated with temporomandibular joint disorders: a systematic review. OAlib. 2015;2(6).
Veronese N, Cereda E, Solmi M, Fowler SA, Manzato E, Maggi S, Manu P, Abe E, Hayashi K, Allard JP, et al. Inverse relationship between body mass index and mortality in older nursing home residents: a meta-analysis of 19,538 elderly subjects. Obes Rev. 2015;16(11):1001–15.
Article
CAS
Google Scholar
Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005;102(43):15545–50.
Article
CAS
Google Scholar
Chou CH, Chang NW, Shrestha S, Hsu SD, Lin YL, Lee WH, Yang CD, Hong HC, Wei TY, Tu SJ, et al. miRTarBase 2016: updates to the experimentally validated miRNA-target interactions database. Nucleic Acids Res. 2016;44(D1):D239–47.
Article
CAS
Google Scholar
John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets. PLoS Biol. 2004;2(11):e363.
Article
Google Scholar
Kertesz M, Iovino N, Unnerstall U, Gaul U, Segal E. The role of site accessibility in microRNA target recognition. Nat Genet. 2007;39(10):1278–84.
Article
CAS
Google Scholar
Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005;120(1):15–20.
Article
CAS
Google Scholar
Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B Methodol. 1995;57:289–300.
Suzuki A, Pelikan RC, Iwata J. WNT/beta-catenin signaling regulates multiple steps of Myogenesis by regulating step-specific targets. Mol Cell Biol. 2015;35(10):1763–76.
Article
CAS
Google Scholar
Suzuki A, Sangani DR, Ansari A, Iwata J. Molecular mechanisms of midfacial developmental defects. Dev Dyn. 2016;245(3):276–93.
Article
Google Scholar
Obican SG, Finnell RH, Mills JL, Shaw GM, Scialli AR. Folic acid in early pregnancy: a public health success story. FASEB J. 2010;24(11):4167–74.
Article
CAS
Google Scholar
Bille C, Winther JF, Bautz A, Murray JC, Olsen J, Christensen K. Cancer risk in persons with oral cleft--a population-based study of 8,093 cases. Am J Epidemiol. 2005;161(11):1047–55.
Article
Google Scholar
Dunkhase E, Ludwig KU, Knapp M, Skibola CF, Figueiredo JC, Hosking FJ, Ellinghaus E, Landi MT, Ma H, Nakagawa H, et al. Nonsyndromic cleft lip with or without cleft palate and cancer: evaluation of a possible common genetic background through the analysis of GWAS data. Genom Data. 2016;10:22–9.
Article
Google Scholar
Taioli E, Ragin C, Robertson L, Linkov F, Thurman NE, Vieira AR. Cleft lip and palate in family members of cancer survivors. Cancer Investig. 2010;28(9):958–62.
Article
CAS
Google Scholar
Huang JB, Liu YL, Sun PW, Lv XD, Du M, Fan XM. Molecular mechanisms of congenital heart disease. Cardiovasc Pathol. 2010;19(5):e183–93.
Article
CAS
Google Scholar
Torano EG, Garcia MG, Fernandez-Morera JL, Nino-Garcia P, Fernandez AF. The impact of external factors on the epigenome: in utero and over lifetime. Biomed Res Int. 2016;2016:2568635.
Article
Google Scholar
Kitsiou-Tzeli S, Tzetis M. Maternal epigenetics and fetal and neonatal growth. Curr Opin Endocrinol Diabetes Obes. 2017;24(1):43–6.
CAS
PubMed
Google Scholar
Wang S, Sun C, Meng Y, Zhang B, Wang X, Su Y, Shi L, Zhao E. A pilot study: screening target miRNAs in tissue of nonsyndromic cleft lip with or without cleft palate. Exp Ther Med. 2017;13(5):2570–6.
Article
CAS
Google Scholar
Ambros V. The functions of animal microRNAs. Nature. 2004;431(7006):350–5.
Article
CAS
Google Scholar
Compagnucci C, Fish JL, Schwark M, Tarabykin V, Depew MJ. Pax6 regulates craniofacial form through its control of an essential cephalic ectodermal patterning center. Genesis. 2011;49(4):307–25.
Article
CAS
Google Scholar
Grindley JC, Davidson DR, Hill RE. The role of Pax-6 in eye and nasal development. Development. 1995;121(5):1433–42.
CAS
PubMed
Google Scholar
Walther C, Gruss P. Pax-6, a murine paired box gene, is expressed in the developing CNS. Development. 1991;113(4):1435–49.
CAS
PubMed
Google Scholar
Marazita ML, Field LL, Cooper ME, Tobias R, Maher BS, Peanchitlertkajorn S, Liu YE. Nonsyndromic cleft lip with or without cleft palate in China: assessment of candidate regions. Cleft Palate Craniofac J. 2002;39(2):149–56.
Article
Google Scholar
Marazita ML, Field LL, Cooper ME, Tobias R, Maher BS, Peanchitlertkajorn S, Liu YE. Genome scan for loci involved in cleft lip with or without cleft palate, in Chinese multiplex families. Am J Hum Genet. 2002;71(2):349–64.
Article
CAS
Google Scholar
Muenke M. The pit, the cleft and the web. Nat Genet. 2002;32(2):219–20.
Article
CAS
Google Scholar
Momb J, Lewandowski JP, Bryant JD, Fitch R, Surman DR, Vokes SA, Appling DR. Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice. Proc Natl Acad Sci U S A. 2013;110(2):549–54.
Article
CAS
Google Scholar
Blanton SH, Henry RR, Yuan Q, Mulliken JB, Stal S, Finnell RH, Hecht JT. Folate pathway and nonsyndromic cleft lip and palate. Birth Defects Res A Clin Mol Teratol. 2011;91(1):50–60.
Article
CAS
Google Scholar
Munger RG, Tamura T, Johnston KE, Feldkamp ML, Pfister R, Cutler R, Murtaugh MA, Carey JC. Oral clefts and maternal biomarkers of folate-dependent one-carbon metabolism in Utah. Birth Defects Res A Clin Mol Teratol. 2011;91(3):153–61.
Article
CAS
Google Scholar
Boyles AL, Wilcox AJ, Taylor JA, Shi M, Weinberg CR, Meyer K, Fredriksen A, Ueland PM, Johansen AM, Drevon CA, et al. Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin a: a pathway-wide association study. Genet Epidemiol. 2009;33(3):247–55.
Article
Google Scholar
Boyles AL, Wilcox AJ, Taylor JA, Meyer K, Fredriksen A, Ueland PM, Drevon CA, Vollset SE, Lie RT. Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts. Am J Med Genet A. 2008;146A(4):440–9.
Article
CAS
Google Scholar
Beaty TH, Murray JC, Marazita ML, Munger RG, Ruczinski I, Hetmanski JB, Liang KY, Wu T, Murray T, Fallin MD, et al. A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4. Nat Genet. 2010;42(6):525–9.
Article
CAS
Google Scholar
Lee MK, Shaffer JR, Leslie EJ, Orlova E, Carlson JC, Feingold E, Marazita ML, Weinberg SM. Genome-wide association study of facial morphology reveals novel associations with FREM1 and PARK2. PLoS One. 2017;12(4):e0176566.
Article
Google Scholar
Leslie EJ, Carlson JC, Shaffer JR, Butali A, Buxo CJ, Castilla EE, Christensen K, Deleyiannis FW, Leigh Field L, Hecht JT, et al. Genome-wide meta-analyses of nonsyndromic orofacial clefts identify novel associations between FOXE1 and all orofacial clefts, and TP63 and cleft lip with or without cleft palate. Hum Genet. 2017;136(3):275–86.
Article
CAS
Google Scholar
Leslie EJ, Taub MA, Liu H, Steinberg KM, Koboldt DC, Zhang Q, Carlson JC, Hetmanski JB, Wang H, Larson DE, et al. Identification of functional variants for cleft lip with or without cleft palate in or near PAX7, FGFR2, and NOG by targeted sequencing of GWAS loci. Am J Hum Genet. 2015;96(3):397–411.
Article
CAS
Google Scholar
Butali A, Suzuki S, Cooper ME, Mansilla AM, Cuenco K, Leslie EJ, Suzuki Y, Niimi T, Yamamoto M, Ayanga G, et al. Replication of genome wide association identified candidate genes confirm the role of common and rare variants in PAX7 and VAX1 in the etiology of nonsyndromic CL(P). Am J Med Genet A. 2013;161A(5):965–72.
Article
Google Scholar
Ma L, Xu M, Li D, Han Y, Wang Z, Yuan H, Ma J, Zhang W, Jiang H, Pan Y, et al. A miRNA-binding-site SNP of MSX1 is associated with NSOC susceptibility. J Dent Res. 2014;93(6):559–64.
Article
CAS
Google Scholar
Li D, Zhang H, Ma L, Han Y, Xu M, Wang Z, Jiang H, Zhang W, Wang L, Pan Y. Associations between microRNA binding site SNPs in FGFs and FGFRs and the risk of non-syndromic orofacial cleft. Sci Rep. 2016;6:31054.
Article
CAS
Google Scholar
Li J, Zou J, Li Q, Chen L, Gao Y, Yan H, Zhou B, Li J. Assessment of differentially expressed plasma microRNAs in nonsyndromic cleft palate and nonsyndromic cleft lip with cleft palate. Oncotarget. 2016;7(52):86266–79.
PubMed
PubMed Central
Google Scholar
Nie X, Wang Q, Jiao K. Dicer activity in neural crest cells is essential for craniofacial organogenesis and pharyngeal arch artery morphogenesis. Mech Dev. 2011;128(3–4):200–7.
Article
CAS
Google Scholar
Huang T, Liu Y, Huang M, Zhao X, Cheng L. Wnt1-cre-mediated conditional loss of dicer results in malformation of the midbrain and cerebellum and failure of neural crest and dopaminergic differentiation in mice. J Mol Cell Biol. 2010;2(3):152–63.
Article
CAS
Google Scholar
Zehir A, Hua LL, Maska EL, Morikawa Y, Cserjesi P. Dicer is required for survival of differentiating neural crest cells. Dev Biol. 2010;340(2):459–67.
Article
CAS
Google Scholar
Sheehy NT, Cordes KR, White MP, Ivey KN, Srivastava D. The neural crest-enriched microRNA miR-452 regulates epithelial-mesenchymal signaling in the first pharyngeal arch. Development. 2010;137(24):4307–16.
Article
CAS
Google Scholar
Wu G, Zheng K, Xia S, Wang Y, Meng X, Qin X, Cheng Y. MicroRNA-655-3p functions as a tumor suppressor by regulating ADAM10 and beta-catenin pathway in hepatocellular carcinoma. J Exp Clin Cancer Res. 2016;35(1):89.
Article
Google Scholar
Zhao XQ, Liang B, Jiang K, Zhang HY. Down-regulation of miR-655-3p predicts worse clinical outcome in patients suffering from hepatocellular carcinoma. Eur Rev Med Pharmacol Sci. 2017;21(4):748–52.
PubMed
Google Scholar
Chai L, Kang XJ, Sun ZZ, Zeng MF, Yu SR, Ding Y, Liang JQ, Li TT, Zhao J. MiR-497-5p, miR-195-5p and miR-455-3p function as tumor suppressors by targeting hTERT in melanoma A375 cells. Cancer Manag Res. 2018;10:989–1003.
Article
Google Scholar
Chen Y, Kuang D, Zhao X, Chen D, Wang X, Yang Q, Wan J, Zhu Y, Wang Y, Zhang S, et al. miR-497-5p inhibits cell proliferation and invasion by targeting KCa3.1 in angiosarcoma. Oncotarget. 2016;7(36):58148–61.
PubMed
PubMed Central
Google Scholar
Sun Z, Li A, Yu Z, Li X, Guo X, Chen R. MicroRNA-497-5p Suppresses Tumor Cell Growth of Osteosarcoma by Targeting ADP Ribosylation Factor-Like Protein 2. Cancer Biother Radiopharm. 2017;32(10):371–8.
Article
CAS
Google Scholar
Chen X, Shi C, Wang C, Liu W, Chu Y, Xiang Z, Hu K, Dong P, Han X. The role of miR-497-5p in myofibroblast differentiation of LR-MSCs and pulmonary fibrogenesis. Sci Rep. 2017;7:40958.
Article
CAS
Google Scholar
Wyszynski DF, Beaty TH. Review of the role of potential teratogens in the origin of human nonsyndromic oral clefts. Teratology. 1996;53(5):309–17.
Article
CAS
Google Scholar
Felix TM, Hanshaw BC, Mueller R, Bitoun P, Murray JC. CHD7 gene and non-syndromic cleft lip and palate. Am J Med Genet A. 2006;140(19):2110–4.
Article
Google Scholar
Mohamad Shah NS, Salahshourifar I, Sulong S, Wan Sulaiman WA, Halim AS. Discovery of candidate genes for nonsyndromic cleft lip palate through genome-wide linkage analysis of large extended families in the Malay population. BMC Genet. 2016;17:39.
Article
Google Scholar
Riley BM, Schultz RE, Cooper ME, Goldstein-McHenry T, Daack-Hirsch S, Lee KT, Dragan E, Vieira AR, Lidral AC, Marazita ML, et al. A genome-wide linkage scan for cleft lip and cleft palate identifies a novel locus on 8p11-23. Am J Med Genet A. 2007;143A(8):846–52.
Article
CAS
Google Scholar
Green RM, Feng W, Phang T, Fish JL, Li H, Spritz RA, Marcucio RS, Hooper J, Jamniczky H, Hallgrimsson B, et al. Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage. Dis Model Mech. 2015;8(1):31–43.
Article
CAS
Google Scholar
Milunsky JM, Maher TA, Zhao G, Roberts AE, Stalker HJ, Zori RT, Burch MN, Clemens M, Mulliken JB, Smith R, et al. TFAP2A mutations result in branchio-oculo-facial syndrome. Am J Hum Genet. 2008;82(5):1171–7.
Article
CAS
Google Scholar
Xu H, Niu Y, Wang T, Liu S, Xu H, Wang S, Liu J, Ye Z. Novel FGFR1 and KISS1R mutations in Chinese Kallmann syndrome males with cleft lip/palate. Biomed Res Int. 2015;2015:649698.
PubMed
PubMed Central
Google Scholar
Simonis N, Migeotte I, Lambert N, Perazzolo C, de Silva DC, Dimitrov B, Heinrichs C, Janssens S, Kerr B, Mortier G, et al. FGFR1 mutations cause Hartsfield syndrome, the unique association of holoprosencephaly and ectrodactyly. J Med Genet. 2013;50(9):585–92.
Article
CAS
Google Scholar
Mao XY, Tang SJ. Effects of phenytoin on Satb2 and Hoxa2 gene expressions in mouse embryonic craniofacial tissue. Biochem Cell Biol. 2010;88(4):731–5.
Article
CAS
Google Scholar
Quaderi NA, Schweiger S, Gaudenz K, Franco B, Rugarli EI, Berger W, Feldman GJ, Volta M, Andolfi G, Gilgenkrantz S, et al. Opitz G/BBB syndrome, a defect of midline development, is due to mutations in a new RING finger gene on Xp22. Nat Genet. 1997;17(3):285–91.
Article
CAS
Google Scholar
Hsieh EW, Vargervik K, Slavotinek AM. Clinical and molecular studies of patients with characteristics of Opitz G/BBB syndrome shows a novel MID1 mutation. Am J Med Genet A. 2008;146A(18):2337–45.
Article
CAS
Google Scholar
Mescher M, Haarmann-Stemmann T. Modulation of CYP1A1 metabolism: from adverse health effects to chemoprevention and therapeutic options. Pharmacol Ther. 2018;187:71–87.
Article
CAS
Google Scholar
Shi M, Christensen K, Weinberg CR, Romitti P, Bathum L, Lozada A, Morris RW, Lovett M, Murray JC. Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants. Am J Hum Genet. 2007;80(1):76–90.
Article
CAS
Google Scholar