World Health Organization. [http://www.who.int]
Morales C, Ribas M, Aiza G, Peinado MA: Genetic determinants of methotrexate responsiveness and resistance in colon cancer cells. Oncogene. 2005, 24: 6842-7.
Article
CAS
PubMed
Google Scholar
Heppner GH, Miller FR: The cellular basis of tumor progression. Int Rev Cytol. 1998, 177: 1-56.
Article
CAS
PubMed
Google Scholar
Chen MJ, Shimada T, Moulton AD, Cline A, Humphries RK, Maizel J, Nienhuis AW: The functional human dihydrofolate reductase gene. J Biol Chem. 1984, 259: 3933-43.
CAS
PubMed
Google Scholar
Chu E, Grem JL, Johnston PG, Allegra CJ: New concepts for the development and use of antifolates. Stem Cells. 1996, 14: 41-6.
Article
CAS
PubMed
Google Scholar
Guglielmi A, Barni S, Zaniboni A, Pella N, Belvedere O, Beretta GD, Grossi F, Frontini L, Puglisi F, Labianca R, Sobrero A: Phase II study of a triplet regimen in advanced colorectal cancer using methotrexate, oxaliplatin and 5-fluorouracil. Br J Cancer. 2004, 91: 1428-33.
CAS
PubMed
PubMed Central
Google Scholar
Sobrero A, Frassineti G, Falcone A, Dogliotti L, Rosso R, Di Costanzo F, Bruzzi P: Adjuvant sequential methotrexate --> 5-fluorouracil vs 5-fluorouracil plus leucovorin in radically resected stage III and high-risk stage II colon cancer. Br J Cancer. 2005, 92: 24-9.
Article
CAS
PubMed
Google Scholar
Zampino MG, Lorizzo K, Rocca A, Locatelli M, Zorzino L, Manzoni S, Mazzetta C, Fazio N, Biffi R, De Braud F: Oxaliplatin combined with 5-fluorouracil and methotrexate in advanced colorectal cancer. Anticancer Res. 2006, 26: 2425-8.
CAS
PubMed
Google Scholar
Albertson DG, Collins C, McCormick F, Gray JW: Chromosome aberrations in solid tumors. Nat Genet. 2003, 34: 369-76.
Article
CAS
PubMed
Google Scholar
Singer MJ, Mesner LD, Friedman CL, Trask BJ, Hamlin JL: Amplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaks. Proc Natl Acad Sci USA. 2000, 97: 7921-6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rots MG, Pieters R, Kaspers GJ, Veerman AJ, Peters GJ, Jansen G: Classification of ex vivo methotrexate resistance in acute lymphoblastic and myeloid leukaemia. Br J Haematol. 2000, 110: 791-800.
Article
CAS
PubMed
Google Scholar
Selga E, Noe V, Ciudad CJ: Transcriptional regulation of aldo-keto reductase 1C1 in HT29 human colon cancer cells resistant to methotrexate: role in the cell cycle and apoptosis. Biochem Pharmacol. 2008, 75: 414-26.
Article
CAS
PubMed
Google Scholar
Gene Expression Omnibus. [http://www.ncbi.nlm.nih.gov/geo/]
Rocke DM, Durbin B: A model for measurement error for gene expression arrays. J Comput Biol. 2001, 8: 557-69.
Article
CAS
PubMed
Google Scholar
Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983, 65: 55-63.
Article
CAS
PubMed
Google Scholar
Torres VA, Tapia JC, Rodriguez DA, Lladser A, Arredondo C, Leyton L, Quest AF: E-cadherin is required for caveolin-1-mediated down-regulation of the inhibitor of apoptosis protein survivin via reduced beta-catenin-Tcf/Lef-dependent transcription. Mol Cell Biol. 2007, 27: 7703-17.
Article
CAS
PubMed
PubMed Central
Google Scholar
Drummond JT, Genschel J, Wolf E, Modrich P: DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair. Proc Natl Acad Sci USA. 1997, 94: 10144-9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pandit B, Roy M, Dutta J, Padhi BK, Bhoumik G, Bhattacharyya NP: Co-amplification of dhfr and a homologue of hmsh3 in a Chinese hamster methotrexate-resistant cell line correlates with resistance to a range of chemotherapeutic drugs. Cancer Chemother Pharmacol. 2001, 48: 312-8.
Article
CAS
PubMed
Google Scholar
Jones KR, Gewirtz DA, Yannone SM, Zhou S, Schatz DG, Valerie K, Povirk LF: Radiosensitization of MDA-MB-231 breast tumor cells by adenovirus-mediated overexpression of a fragment of the XRCC4 protein. Mol Cancer Ther. 2005, 4: 1541-7.
Article
CAS
PubMed
Google Scholar
Arozarena I, Matallanas D, Berciano MT, Sanz-Moreno V, Calvo F, Munoz MT, Egea G, Lafarga M, Crespo P: Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors. Mol Cell Biol. 2004, 24: 1516-30.
Article
CAS
PubMed
PubMed Central
Google Scholar
Malumbres M, Pellicer A: RAS pathways to cell cycle control and cell transformation. Front Biosci. 1998, 3: d887-912.
Article
CAS
PubMed
Google Scholar
Liang H, Samanta S, Nagarajan L: SSBP2, a candidate tumor suppressor gene, induces growth arrest and differentiation of myeloid leukemia cells. Oncogene. 2005, 24: 2625-34.
Article
CAS
PubMed
Google Scholar
Rezaee M, Penta K, Quertermous T: Del1 mediates VSMC adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3). Am J Physiol Heart Circ Physiol. 2002, 282: H1924-32.
Article
CAS
PubMed
Google Scholar
Petitclerc E, Stromblad S, von Schalscha TL, Mitjans F, Piulats J, Montgomery AM, Cheresh DA, Brooks PC: Integrin alpha(v)beta3 promotes M21 melanoma growth in human skin by regulating tumor cell survival. Cancer Res. 1999, 59: 2724-30.
CAS
PubMed
Google Scholar
Yeh CS, Wang JY, Chung FY, Lee SC, Huang MY, Kuo CW, Yang MJ, Lin SR: Significance of the glycolytic pathway and glycolysis related-genes in tumorigenesis of human colorectal cancers. Oncol Rep. 2008, 19: 81-91.
CAS
PubMed
Google Scholar
Karnak D, Beder S, Kayacan O, Ibis E, Oflaz G: Neuron-specific enolase and lung cancer. Am J Clin Oncol. 2005, 28: 586-90.
Article
CAS
PubMed
Google Scholar
Fujiwara H, Arima N, Ohtsubo H, Matsumoto T, Kukita T, Kawada H, Imaizumi R, Ozaki A, Matsushita K, Tei C: Clinical significance of serum neuron-specific enolase in patients with adult T-cell leukemia. Am J Hematol. 2002, 71: 80-4.
Article
CAS
PubMed
Google Scholar
Kitakata H, Yasumoto K, Sudo Y, Minato H, Takahashi Y: A case of primary small cell carcinoma of the breast. Breast Cancer. 2007, 14: 414-9.
Article
PubMed
Google Scholar
Katayama M, Nakano H, Ishiuchi A, Wu W, Oshima R, Sakurai J, Nishikawa H, Yamaguchi S, Otsubo T: Protein pattern difference in the colon cancer cell lines examined by two-dimensional differential in-gel electrophoresis and mass spectrometry. Surg Today. 2006, 36: 1085-93.
Article
CAS
PubMed
Google Scholar
Yu G, Ahmad S, Aquino A, Fairchild CR, Trepel JB, Ohno S, Suzuki K, Tsuruo T, Cowan KH, Glazer RI: Transfection with protein kinase C alpha confers increased multidrug resistance to MCF-7 cells expressing P-glycoprotein. Cancer Commun. 1991, 3: 181-9.
CAS
PubMed
Google Scholar
Lavie Y, Fiucci G, Liscovitch M: Up-regulation of caveolae and caveolar constituents in multidrug-resistant cancer cells. J Biol Chem. 1998, 273: 32380-3.
Article
CAS
PubMed
Google Scholar
Martelli AM, Sang N, Borgatti P, Capitani S, Neri LM: Multiple biological responses activated by nuclear protein kinase C. J Cell Biochem. 1999, 74: 499-521.
Article
CAS
PubMed
Google Scholar
Wang XY, Repasky E, Liu HT: Antisense inhibition of protein kinase Calpha reverses the transformed phenotype in human lung carcinoma cells. Exp Cell Res. 1999, 250: 253-63.
Article
CAS
PubMed
Google Scholar
Noe V, Ciudad CJ: Protein kinase C inhibitors reduce phorbol ester-induced resistance to methotrexate in Chinese hamster ovary cells. Biochem Pharmacol. 1995, 50: 337-46.
Article
CAS
PubMed
Google Scholar
Ahmad S, Glazer RI: Expression of the antisense cDNA for protein kinase C alpha attenuates resistance in doxorubicin-resistant MCF-7 breast carcinoma cells. Mol Pharmacol. 1993, 43: 858-62.
CAS
PubMed
Google Scholar
Wang XY, Liu HT: Antisense expression of protein kinase C alpha improved sensitivity to anticancer drugs in human lung cancer LTEPa-2 cells. Zhongguo Yao Li Xue Bao. 1998, 19: 265-8.
CAS
PubMed
Google Scholar
Isonishi S, Ohkawa K, Tanaka T, Howell SB: Depletion of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) enhances platinum drug sensitivity in human ovarian carcinoma cells. Br J Cancer. 2000, 82: 34-8.
Article
CAS
PubMed
Google Scholar
Lahn M, Kohler G, Sundell K, Su C, Li S, Paterson BM, Bumol TF: Protein kinase C alpha expression in breast and ovarian cancer. Oncology. 2004, 67: 1-10.
Article
CAS
PubMed
Google Scholar
Geiger T, Muller M, Dean NM, Fabbro D: Antitumor activity of a PKC-alpha antisense oligonucleotide in combination with standard chemotherapeutic agents against various human tumors transplanted into nude mice. Anticancer Drug Des. 1998, 13: 35-45.
CAS
PubMed
Google Scholar
Thompson TC: Metastasis-related genes in prostate cancer: the role of caveolin-1. Cancer Metastasis Rev. 1998, 17: 439-42.
Article
CAS
PubMed
Google Scholar
Yang G, Truong LD, Timme TL, Ren C, Wheeler TM, Park SH, Nasu Y, Bangma CH, Kattan MW, Scardino PT, Thompson TC: Elevated expression of caveolin is associated with prostate and breast cancer. Clin Cancer Res. 1998, 4: 1873-80.
CAS
PubMed
Google Scholar
Ho CC, Huang PH, Huang HY, Chen YH, Yang PC, Hsu SM: Up-regulated caveolin-1 accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formation. Am J Pathol. 2002, 161: 1647-56.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li L, Yang G, Ebara S, Satoh T, Nasu Y, Timme TL, Ren C, Wang J, Tahir SA, Thompson TC: Caveolin-1 mediates testosterone-stimulated survival/clonal growth and promotes metastatic activities in prostate cancer cells. Cancer Res. 2001, 61: 4386-92.
CAS
PubMed
Google Scholar
Kato K, Hida Y, Miyamoto M, Hashida H, Shinohara T, Itoh T, Okushiba S, Kondo S, Katoh H: Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage. Cancer. 2002, 94: 929-33.
Article
CAS
PubMed
Google Scholar
Mouraviev V, Li L, Tahir SA, Yang G, Timme TM, Goltsov A, Ren C, Satoh T, Wheeler TM, Ittmann MM, Miles BJ, Amato RJ, Kadmon D, Thompson TC: The role of caveolin-1 in androgen insensitive prostate cancer. J Urol. 2002, 168: 1589-96.
Article
CAS
PubMed
Google Scholar
Bender FC, Reymond MA, Bron C, Quest AF: Caveolin-1 levels are down-regulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity. Cancer Res. 2000, 60: 5870-8.
CAS
PubMed
Google Scholar
Benimetskaya L, Miller P, Benimetsky S, Maciaszek A, Guga P, Beaucage SL, Wilk A, Grajkowski A, Halperin AL, Stein CA: Inhibition of potentially anti-apoptotic proteins by antisense protein kinase C-alpha (Isis 3521) and antisense bcl-2 (G3139) phosphorothioate oligodeoxynucleotides: relationship to the decreased viability of T24 bladder and PC3 prostate cancer cells. Mol Pharmacol. 2001, 60: 1296-307.
CAS
PubMed
Google Scholar
Behrens J, Mareel MM, Van Roy FM, Birchmeier W: Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J Cell Biol. 1989, 108: 2435-47.
Article
CAS
PubMed
Google Scholar
Perl AK, Wilgenbus P, Dahl U, Semb H, Christofori G: A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature. 1998, 392: 190-3.
Article
CAS
PubMed
Google Scholar
Cavallaro U, Christofori G: Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer. 2004, 4: 118-32.
Article
CAS
PubMed
Google Scholar
Frixen UH, Behrens J, Sachs M, Eberle G, Voss B, Warda A, Lochner D, Birchmeier W: E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol. 1991, 113: 173-85.
Article
CAS
PubMed
Google Scholar
Munro SB, Turner IM, Farookhi R, Blaschuk OW, Jothy S: E-cadherin and OB-cadherin mRNA levels in normal human colon and colon carcinoma. Exp Mol Pathol. 1995, 62: 118-22.
Article
CAS
PubMed
Google Scholar
Suzuki H, Komiya A, Emi M, Kuramochi H, Shiraishi T, Yatani R, Shimazaki J: Three distinct commonly deleted regions of chromosome arm 16q in human primary and metastatic prostate cancers. Genes Chromosomes Cancer. 1996, 17: 225-33.
Article
CAS
PubMed
Google Scholar
Cheng L, Nagabhushan M, Pretlow TP, Amini SB, Pretlow TG: Expression of E-cadherin in primary and metastatic prostate cancer. Am J Pathol. 1996, 148: 1375-80.
CAS
PubMed
PubMed Central
Google Scholar
Derksen PW, Liu X, Saridin F, Gulden van der H, Zevenhoven J, Evers B, van Beijnum JR, Griffioen AW, Vink J, Krimpenfort P, Peterse JL, Cardiff RD, Berns A, Jonkers J: Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. Cancer Cell. 2006, 10: 437-49.
Article
CAS
PubMed
Google Scholar
Masur K, Lang K, Niggemann B, Zanker KS, Entschladen F: High PKC alpha and low E-cadherin expression contribute to high migratory activity of colon carcinoma cells. Mol Biol Cell. 2001, 12: 1973-82.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lisanti MP, Scherer PE, Vidugiriene J, Tang Z, Hermanowski-Vosatka A, Tu YH, Cook RF, Sargiacomo M: Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease. J Cell Biol. 1994, 126: 111-26.
Article
CAS
PubMed
Google Scholar
Liu P, Rudick M, Anderson RG: Multiple functions of caveolin-1. J Biol Chem. 2002, 277: 41295-8.
Article
CAS
PubMed
Google Scholar
Oka N, Yamamoto M, Schwencke C, Kawabe J, Ebina T, Ohno S, Couet J, Lisanti MP, Ishikawa Y: Caveolin interaction with protein kinase C. Isoenzyme-dependent regulation of kinase activity by the caveolin scaffolding domain peptide. J Biol Chem. 1997, 272: 33416-21.
Article
CAS
PubMed
Google Scholar
Okamoto T, Schlegel A, Scherer PE, Lisanti MP: Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane. J Biol Chem. 1998, 273: 5419-22.
Article
CAS
PubMed
Google Scholar
Okegawa T, Pong RC, Li Y, Hsieh JT: The role of cell adhesion molecule in cancer progression and its application in cancer therapy. Acta Biochim Pol. 2004, 51: 445-57.
CAS
PubMed
Google Scholar
Brabletz T, Jung A, Reu S, Porzner M, Hlubek F, Kunz-Schughart LA, Knuechel R, Kirchner T: Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc Natl Acad Sci USA. 2001, 98: 10356-61.
Article
CAS
PubMed
PubMed Central
Google Scholar