Lai A, Moon A, Purmessur D, Skovrlj B, Winkelstein BA, Cho SK, et al. Assessment of functional and behavioral changes sensitive to painful disc degeneration. J Orthop Res Off Publ Orthop Res Soc. 2015;33(5):755–64.
Article
Google Scholar
Hu B, Shi C, Tian Y, Zhang Y, Xu C, Chen H, et al. TGF-beta induces up-regulation of chondroitin sulfate synthase 1 (CHSY1) in nucleus pulposus cells through MAPK signaling. Cell Physiol Biochem Int J Exp Cell Physiol Biochem Pharmacol. 2015;37(2):793–804.
Article
CAS
Google Scholar
Hu B, Xu C, Tian Y, Shi C, Zhang Y, Deng L, et al. Inflammatory microRNA-194 and -515 attenuate the biosynthesis of chondroitin sulfate during human intervertebral disc degeneration. Oncotarget. 2017;8(30):49303–17.
Article
Google Scholar
Nakayama E, Matsumoto T, Kazama T, Kano K, Tokuhashi Y. Transplantation of dedifferentiation fat cells promotes intervertebral disc regeneration in a rat intervertebral disc degeneration model. Biochem Biophys Res Commun. 2017;493(2):1004–9.
Article
CAS
Google Scholar
Nikkhoo M, Wang JL, Parnianpour M, El-Rich M, Khalaf K. Biomechanical response of intact, degenerated and repaired intervertebral discs under impact loading—ex-vivo and in-silico investigation. J Biomech. 2018;70:26–32.
Article
Google Scholar
Iatridis JC, Nicoll SB, Michalek AJ, Walter BA, Gupta MS. Role of biomechanics in intervertebral disc degeneration and regenerative therapies: what needs repairing in the disc and what are promising biomaterials for its repair? Spine J Off J N Am Spine Soc. 2013;13(3):243–62.
Article
Google Scholar
Vergroesen PP, Kingma I, Emanuel KS, Hoogendoorn RJ, Welting TJ, van Royen BJ, et al. Mechanics and biology in intervertebral disc degeneration: a vicious circle. Osteoarthr Cartil. 2015;23(7):1057–70.
Article
Google Scholar
Sakai D, Nakamura Y, Nakai T, Mishima T, Kato S, Grad S, et al. Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc. Nat Commun. 2012;3:1264.
Article
Google Scholar
Risbud MV, Shapiro IM. Role of cytokines in intervertebral disc degeneration: pain and disc content. Nat Rev Rheumatol. 2014;10(1):44–56.
Article
CAS
Google Scholar
Hu B, Xu C, Cao P, Tian Y, Zhang Y, Shi C, et al. TGF-beta stimulates expression of chondroitin polymerizing factor in nucleus pulposus cells through the Smad3, RhoA/ROCK1, and MAPK signaling pathways. J Cell Biochem. 2018;119(1):566–79.
Article
CAS
Google Scholar
Xu C, Zhang Y, Wang Q, Xu Z, Jiang J, Gao Y, et al. Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling. Nat Commun. 2016;7:13287.
Article
CAS
Google Scholar
Xu C, Chen Y, Zhang H, Chen Y, Shen X, Shi C, et al. Integrated microRNA-mRNA analyses reveal OPLL specific microRNA regulatory network using high-throughput sequencing. Sci Rep. 2016;6:21580.
Article
CAS
Google Scholar
Guo W, Zhang B, Li Y, Duan HQ, Sun C, Xu YQ, et al. Gene expression profile identifies potential biomarkers for human intervertebral disc degeneration. Mol Med Rep. 2017;16(6):8665–72.
Article
CAS
Google Scholar
Hu B, Shi C, Xu C, Cao P, Tian Y, Zhang Y, et al. Heme oxygenase-1 attenuates IL-1beta induced alteration of anabolic and catabolic activities in intervertebral disc degeneration. Sci Rep. 2016;6:21190.
Article
CAS
Google Scholar
Quax TE, Wolf YI, Koehorst JJ, Wurtzel O, van der Oost R, Ran W, et al. Differential translation tunes uneven production of operon-encoded proteins. Cell Rep. 2013;4(5):938–44.
Article
CAS
Google Scholar
Ye D, Liang W, Dai L, Zhou L, Yao Y, Zhong X, et al. Comparative and quantitative proteomic analysis of normal and degenerated human annulus fibrosus cells. Clin Exp Pharmacol Physiol. 2015;42(5):530–6.
Article
CAS
Google Scholar
Wang XC, Li Q, Jin X, Xiao GH, Liu GJ, Liu NJ, et al. Quantitative proteomics and transcriptomics reveal key metabolic processes associated with cotton fiber initiation. J Proteomics. 2015;114:16–27.
Article
CAS
Google Scholar
McCann MR, Patel P, Frimpong A, Xiao Y, Siqueira WL, Seguin CA. Proteomic signature of the murine intervertebral disc. PLoS ONE. 2015;10(2):e0117807.
Article
Google Scholar
Yee A, Lam MP, Tam V, Chan WC, Chu IK, Cheah KS, et al. Fibrotic-like changes in degenerate human intervertebral discs revealed by quantitative proteomic analysis. Osteoarthr Cartil. 2016;24(3):503–13.
Article
CAS
Google Scholar
Lv FJ, Peng Y, Lim FL, Sun Y, Lv M, Zhou L, et al. Matrix metalloproteinase 12 is an indicator of intervertebral disc degeneration co-expressed with fibrotic markers. Osteoarthr Cartil. 2016;24(10):1826–36.
Article
Google Scholar
Rodrigues-Pinto R, Berry A, Piper-Hanley K, Hanley N, Richardson SM, Hoyland JA. Spatiotemporal analysis of putative notochordal cell markers reveals CD24 and keratins 8, 18, and 19 as notochord-specific markers during early human intervertebral disc development. J Orthop Res Off Publ Orthop Res Soc. 2016;34(8):1327–40.
Article
CAS
Google Scholar
Martirosyan NL, Patel AA, Carotenuto A, Kalani MY, Belykh E, Walker CT, et al. Genetic alterations in intervertebral disc disease. Front Surg. 2016;3:59.
PubMed
PubMed Central
Google Scholar
Song YQ, Karasugi T, Cheung KM, Chiba K, Ho DW, Miyake A, et al. Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant. J Clin Invest. 2013;123(11):4909–17.
Article
CAS
Google Scholar
Yue B, Lin Y, Ma X, Xiang H, Qiu C, Zhang J, et al. Survivin-TGFB3-TIMP1 gene therapy via lentivirus vector slows the course of intervertebral disc degeneration in an in vivo rabbit model. Spine (Phila Pa 1976). 2016;41(11):926–34.
Article
Google Scholar
Noponen-Hietala N, Kyllonen E, Mannikko M, Ilkko E, Karppinen J, Ott J, et al. Sequence variations in the collagen IX and XI genes are associated with degenerative lumbar spinal stenosis. Ann Rheum Dis. 2003;62(12):1208–14.
Article
CAS
Google Scholar
Nakki A, Battie MC, Kaprio J. Genetics of disc-related disorders: current findings and lessons from other complex diseases. Eur Spine J Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sect Cerv Spine Res Soc. 2014;23(Suppl 3):S354–63.
Article
Google Scholar
Kazezian Z, Li Z, Alini M, Grad S, Pandit A. Injectable hyaluronic acid down-regulates interferon signaling molecules, IGFBP3 and IFIT3 in the bovine intervertebral disc. Acta Biomater. 2017;52:118–29.
Article
CAS
Google Scholar
Johnson ZI, Schoepflin ZR, Choi H, Shapiro IM, Risbud MV. Disc in flames: Roles of TNF-alpha and IL-1beta in intervertebral disc degeneration. Eur Cells Mater. 2015;30:104–16 (discussion 16-7).
Article
CAS
Google Scholar
Kazezian Z, Gawri R, Haglund L, Ouellet J, Mwale F, Tarrant F, et al. Gene expression profiling identifies interferon signalling molecules and IGFBP3 in human degenerative annulus fibrosus. Sci Rep. 2015;5:15662.
Article
CAS
Google Scholar
Sato S, Kimura A, Ozdemir J, Asou Y, Miyazaki M, Jinno T, et al. The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration: findings in murine models and in human disease. Arthr Rheum. 2008;58(9):2764–75.
Article
Google Scholar
Feng Y, Egan B, Wang J. Genetic factors in intervertebral disc degeneration. Genes Dis. 2016;3(3):178–85.
Article
Google Scholar
Sarath Babu N, Krishnan S, Brahmendra Swamy CV, Venkata Subbaiah GP, Gurava Reddy AV, Idris MM. Quantitative proteomic analysis of normal and degenerated human intervertebral disc. Spine J Off J N Am Spine Soc. 2016;16(8):989–1000.
Article
Google Scholar
Zhang Y, Xu C, Gu D, Wu M, Yan B, Xu Z, et al. H/ACA box small nucleolar RNA 7A promotes the self-renewal of human umbilical cord mesenchymal stem cells. Stem Cells. 2017;35(1):222–35.
Article
CAS
Google Scholar
Cho KH, Kim JH. Cis-encoded non-coding antisense RNAs in streptococci and other low GC Gram (+) bacterial pathogens. Front Genet. 2015;6:110.
Article
Google Scholar
Wang Y, Xu Z, Jiang J, Xu C, Kang J, Xiao L, et al. Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal. Dev Cell. 2013;25(1):69–80.
Article
CAS
Google Scholar
Pereira Fernandes D, Bitar M, Jacobs FMJ, Barry G. Long non-coding RNAs in neuronal aging. Noncoding RNA. 2018;4(2):12.
PubMed Central
Google Scholar
Vo NV, Hartman RA, Yurube T, Jacobs LJ, Sowa GA, Kang JD. Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration. Spine J Off J N Am Spine Soc. 2013;13(3):331–41.
Article
Google Scholar
Lv F, Leung VY, Huang S, Huang Y, Sun Y, Cheung KM. In search of nucleus pulposus-specific molecular markers. Rheumatology (Oxford). 2014;53(4):600–10.
Article
CAS
Google Scholar
Maroudas A, Stockwell RA, Nachemson A, Urban J. Factors involved in the nutrition of the human lumbar intervertebral disc: cellularity and diffusion of glucose in vitro. J Anat. 1975;120(Pt 1):113–30.
CAS
PubMed
PubMed Central
Google Scholar