Skip to main content


Page 43 of 43

  1. The etiology of many chronic diseases involves interactions between environmental factors and genes that modulate physiological processes. Understanding interactions between environmental chemicals and genes/p...

    Authors: Allan P Davis, Cynthia G Murphy, Michael C Rosenstein, Thomas C Wiegers and Carolyn J Mattingly
    Citation: BMC Medical Genomics 2008 1:48
  2. Hypermethylation of promoter CpG islands with associated loss of gene expression, and hypomethylation of CpG-rich repetitive elements that may destabilize the genome are common events in most, if not all, epit...

    Authors: George S Watts, Bernard W Futscher, Nicholas Holtan, Koen DeGeest, Frederick E Domann and Stephen L Rose
    Citation: BMC Medical Genomics 2008 1:47
  3. Inflammation is a hallmark of many human diseases. Elucidating the mechanisms underlying systemic inflammation has long been an important topic in basic and clinical research. When primary pathogenetic events ...

    Authors: Bor-Sen Chen, Shih-Kuang Yang, Chung-Yu Lan and Yung-Jen Chuang
    Citation: BMC Medical Genomics 2008 1:46
  4. While BMPR2 mutation strongly predisposes to pulmonary arterial hypertension (PAH), only 20% of mutation carriers develop clinical disease. This finding suggests that modifier genes contribute to FPAH clinical...

    Authors: James West, Joy Cogan, Mark Geraci, Linda Robinson, John Newman, John A Phillips, Kirk Lane, Barbara Meyrick and Jim Loyd
    Citation: BMC Medical Genomics 2008 1:45
  5. Late-onset Alzheimer's disease (LOAD) is an age related neurodegenerative disease with a high prevalence that places major demands on healthcare resources in societies with increasingly aged populations. The o...

    Authors: Richard Abraham, Valentina Moskvina, Rebecca Sims, Paul Hollingworth, Angharad Morgan, Lyudmila Georgieva, Kimberley Dowzell, Sven Cichon, Axel M Hillmer, Michael C O'Donovan, Julie Williams, Michael J Owen and George Kirov
    Citation: BMC Medical Genomics 2008 1:44
  6. The regulatory subunit of cAMP-dependent protein kinase (PKA) exists in two isoforms, RI and RII, which distinguish the PKA isozymes, type I (PKA-I) and type II (PKA-II). Evidence obtained from a variety of di...

    Authors: Chris Cheadle, Maria Nesterova, Tonya Watkins, Kathleen C Barnes, John C Hall, Antony Rosen, Kevin G Becker and Yoon S Cho-Chung
    Citation: BMC Medical Genomics 2008 1:43
  7. The number of gene expression studies in the public domain is rapidly increasing, representing a highly valuable resource. However, dataset-specific bias precludes meta-analysis at the raw transcript level, ev...

    Authors: Andrew H Sims, Graeme J Smethurst, Yvonne Hey, Michal J Okoniewski, Stuart D Pepper, Anthony Howell, Crispin J Miller and Robert B Clarke
    Citation: BMC Medical Genomics 2008 1:42
  8. The rexinoid bexarotene (LGD1069, Targretin) is a highly selective retinoid × receptor (RXR) agonist that inhibits the growth of pre-malignant and malignant breast cells. Bexarotene was shown to suppress the d...

    Authors: Martin C Abba, Yuhui Hu, Carla C Levy, Sally Gaddis, Frances S Kittrell, Yun Zhang, Jamal Hill, Reid P Bissonnette, Daniel Medina, Powel H Brown and C Marcelo Aldaz
    Citation: BMC Medical Genomics 2008 1:40
  9. Numerous studies have used microarrays to identify gene signatures for predicting cancer patient clinical outcome and responses to chemotherapy. However, the potential impact of gene expression profiling in ca...

    Authors: Jiangang Liu, Andrew Campen, Shuguang Huang, Sheng-Bin Peng, Xiang Ye, Mathew Palakal, A Keith Dunker, Yuni Xia and Shuyu Li
    Citation: BMC Medical Genomics 2008 1:39
  10. Strong epidemiologic evidence correlates tobacco use with a variety of serious adverse health effects, but the biological mechanisms that produce these effects remain elusive.

    Authors: Peter C Charles, Brian D Alder, Eleanor G Hilliard, Jonathan C Schisler, Robert E Lineberger, Joel S Parker, Sabeen Mapara, Samuel S Wu, Andrea Portbury, Cam Patterson and George A Stouffer
    Citation: BMC Medical Genomics 2008 1:38
  11. The role of microRNAs (miRNAs) in multiple myeloma (MM) has yet to be fully elucidated. To identify miRNAs that are potentially deregulated in MM, we investigated those mapping within transcription units, base...

    Authors: Domenica Ronchetti, Marta Lionetti, Laura Mosca, Luca Agnelli, Adrian Andronache, Sonia Fabris, Giorgio Lambertenghi Deliliers and Antonino Neri
    Citation: BMC Medical Genomics 2008 1:37
  12. Neuroblastic tumours (NBTs) represent a heterogeneous spectrum of neoplastic diseases associated with multiple genetic alterations. Structural and numerical chromosomal changes are frequent and are predictive ...

    Authors: Cinzia Lavarino, Idoia Garcia, Carlos Mackintosh, Nai-Kong V Cheung, Gema Domenech, José Ríos, Noelia Perez, Eva Rodríguez, Carmen de Torres, William L Gerald, Esperanza Tuset, Sandra Acosta, Helena Beleta, Enrique de Álava and Jaume Mora
    Citation: BMC Medical Genomics 2008 1:36
  13. Methotrexate is one of the earliest cytotoxic drugs used in cancer therapy, and despite the isolation of multiple other folate antagonists, methotrexate maintains its significant role as a treatment for differ...

    Authors: Elisabet Selga, Cristina Morales, Véronique Noé, Miguel A Peinado and Carlos J Ciudad
    Citation: BMC Medical Genomics 2008 1:35
  14. Expression microarray analyses of epithelial ovarian cancer (EOC) cell lines may be exploited to elucidate genetic and epigenetic events important in this disease. A possible variable is the influence of growt...

    Authors: Neal AL Cody, Magdalena Zietarska, Ali Filali-Mouhim, Diane M Provencher, Anne-Marie Mes-Masson and Patricia N Tonin
    Citation: BMC Medical Genomics 2008 1:34
  15. Recent work, using both cell culture model systems and tumour derived cell lines, suggests that the differential recruitment into polysomes of mRNA populations may be sufficient to initiate and maintain tumour...

    Authors: Raphael Genolet, Tanguy Araud, Laetitia Maillard, Pascale Jaquier-Gubler and Joseph Curran
    Citation: BMC Medical Genomics 2008 1:33
  16. Mechanisms underlying the malignant development in bladder cancer are still not well understood. Lipolysis stimulated lipoprotein receptor (LSR) has previously been found to be upregulated by P53. Furthermore,...

    Authors: Malene Herbsleb, Karin Birkenkamp-Demtroder, Thomas Thykjaer, Carsten Wiuf, Anne-Mette K Hein, Torben F Ørntoft and Lars Dyrskjøt
    Citation: BMC Medical Genomics 2008 1:31
  17. In periodontitis, treatment aimed at controlling the periodontal biofilm infection results in a resolution of the clinical and histological signs of inflammation. Although the cell types found in periodontal t...

    Authors: Thomas Beikler, Ulrike Peters, Karola Prior, Martin Eisenacher and Thomas F Flemmig
    Citation: BMC Medical Genomics 2008 1:30
  18. Persistent infection by high risk HPV types (e.g. HPV-16, -18, -31, and -45) is the main risk factor for development of cervical intraepithelial neoplasia and cervical cancer. Tumor necrosis factor (TNF) is a ...

    Authors: Lara Termini, Enrique Boccardo, Gustavo H Esteves, Roberto Hirata Jr, Waleska K Martins, Anna Estela L Colo, E Jordão Neves, Luisa Lina Villa and Luiz FL Reis
    Citation: BMC Medical Genomics 2008 1:29
  19. Vaginal atrophy (VA) is the thinning of the vaginal epithelial lining, typically the result of lowered estrogen levels during menopause. Some of the consequences of VA include increased susceptibility to bacte...

    Authors: Scott A Jelinsky, Sung E Choe, Judy S Crabtree, Monette M Cotreau, Ewa Wilson, Kathryn Saraf, Andrew J Dorner, Eugene L Brown, Bryan J Peano, Xiaochun Zhang, Richard C Winneker and Heather A Harris
    Citation: BMC Medical Genomics 2008 1:27
  20. Despite advances in the understanding of diabetic retinopathy, the nature and time course of molecular changes in the retina with diabetes are incompletely described. This study characterized the functional an...

    Authors: Robert M Brucklacher, Kruti M Patel, Heather D VanGuilder, Georgina V Bixler, Alistair J Barber, David A Antonetti, Cheng-Mao Lin, Kathryn F LaNoue, Thomas W Gardner, Sarah K Bronson and Willard M Freeman
    Citation: BMC Medical Genomics 2008 1:26
  21. Lung cancer with EGFR mutation was shown to be a specific clinical entity. In order to better understand the biology behind this disease we used a genome wide characterization of loss of heterozygosity and amp...

    Authors: Hélène Blons, Karine Pallier, Delphine Le Corre, Claire Danel, Maxime Tremblay-Gravel, Claude Houdayer, Elizabeth Fabre-Guillevin, Marc Riquet, Philippe Dessen and Pierre Laurent-Puig
    Citation: BMC Medical Genomics 2008 1:25
  22. Variants in numerous genes are thought to affect the success or failure of cancer chemotherapy. Interindividual variability can result from genes involved in drug metabolism and transport, drug targets (recept...

    Authors: Zunyan Dai, Audrey C Papp, Danxin Wang, Heather Hampel and Wolfgang Sadee
    Citation: BMC Medical Genomics 2008 1:24
  23. Angiotensin I-converting enzyme (ACE) plays an important role in cardiovascular homeostasis. There is evidence from different ethnic groups that circulating ACE levels are influenced by a quantitative trait lo...

    Authors: Colin A McKenzie, Xiaofeng Zhu, Terrence E Forrester, Amy Luke, Adebowale A Adeyemo, Nourdine Bouzekri and Richard S Cooper
    Citation: BMC Medical Genomics 2008 1:23
  24. Recent genome-wide association (GWA) studies have provided compelling evidence of association between genetic variants and common complex diseases. These studies have made use of cases and controls almost excl...

    Authors: Sean Myles, Dan Davison, Jeffrey Barrett, Mark Stoneking and Nic Timpson
    Citation: BMC Medical Genomics 2008 1:22
  25. The P-glycoprotein, encoded by the ABCB1 gene, is expressed in human endothelial and mesangial cells, which contribute to control renal plasma flow and glomerular filtration rate. We investigated the association ...

    Authors: Murielle Bochud, Chin B Eap, Marc Maillard, Toby Johnson, Peter Vollenweider, Pascal Bovet, Robert C Elston, Sven Bergmann, Jacques S Beckmann, Dawn M Waterworth, Vincent Mooser, Anne Gabriel and Michel Burnier
    Citation: BMC Medical Genomics 2008 1:21
  26. Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide. At present no reliable biomarkers are available to guide the management of this condition. Microarray technology may allow...

    Authors: Austin Tanney, Gavin R Oliver, Vadim Farztdinov, Richard D Kennedy, Jude M Mulligan, Ciaran E Fulton, Susan M Farragher, John K Field, Patrick G Johnston, D Paul Harkin, Vitali Proutski and Karl A Mulligan
    Citation: BMC Medical Genomics 2008 1:20
  27. The major histocompatibility complex (MHC) is essential for human immunity and is highly associated with common diseases, including cancer. While the genetics of the MHC has been studied intensively for many d...

    Authors: Eleni M Tomazou, Vardhman K Rakyan, Gregory Lefebvre, Robert Andrews, Peter Ellis, David K Jackson, Cordelia Langford, Matthew D Francis, Liselotte Bäckdahl, Marcos Miretti, Penny Coggill, Diego Ottaviani, Denise Sheer, Adele Murrell and Stephan Beck
    Citation: BMC Medical Genomics 2008 1:19
  28. Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects ~8 million annually culminating in ~2 million deaths. Moreover, about one third of the population is latently infected, 10% of which ...

    Authors: Anat Zvi, Naomi Ariel, John Fulkerson, Jerald C Sadoff and Avigdor Shafferman
    Citation: BMC Medical Genomics 2008 1:18
  29. The aberrant transcription in cancer of genes normally associated with embryonic tissue differentiation at various organ sites may be a hallmark of tumour progression. For example, neuroendocrine differentiati...

    Authors: Maria Vias, Charlie E Massie, Philip East, Helen Scott, Anne Warren, Zongxiang Zhou, Alexander Yu Nikitin, David E Neal and Ian G Mills
    Citation: BMC Medical Genomics 2008 1:17
  30. Atherosclerotic peripheral arterial disease (PAD) affects 8–10 million people in the United States and is associated with a marked impairment in quality of life and an increased risk of cardiovascular events. ...

    Authors: Sharon LR Kardia, M Todd Greene, Eric Boerwinkle, Stephen T Turner and Iftikhar J Kullo
    Citation: BMC Medical Genomics 2008 1:16
  31. DNA amplifications alter gene dosage in cancer genomes by multiplying the gene copy number. Amplifications are quintessential in a considerable number of advanced cancers of various anatomical locations. The a...

    Authors: Samuel Myllykangas, Jarkko Tikka, Tom Böhling, Sakari Knuutila and Jaakko Hollmén
    Citation: BMC Medical Genomics 2008 1:15
  32. Obesity and insulin resistance are two major risk factors underlying the metabolic syndrome. The development of these metabolic disorders is frequently studied, but mainly in liver, skeletal muscle, and adipos...

    Authors: Nicole JW de Wit, Hanneke Bosch-Vermeulen, Philip J de Groot, Guido JEJ Hooiveld, Mechteld M Grootte Bromhaar, Jenny Jansen, Michael Müller and Roelof van der Meer
    Citation: BMC Medical Genomics 2008 1:14
  33. The process of malignant transformation, progression and metastasis of melanoma is poorly understood. Gene expression profiling of human cancer has allowed for a unique insight into the genes that are involved...

    Authors: Adam I Riker, Steven A Enkemann, Oystein Fodstad, Suhu Liu, Suping Ren, Christopher Morris, Yaguang Xi, Paul Howell, Brandon Metge, Rajeev S Samant, Lalita A Shevde, Wenbin Li, Steven Eschrich, Adil Daud, Jingfang Ju and Jaime Matta
    Citation: BMC Medical Genomics 2008 1:13
  34. With the introduction of increasingly powerful mass spectrometry (MS) techniques for clinical research, several recent large-scale MS proteomics studies have sought to characterize the entire human plasma prot...

    Authors: Sudipto Saha, Scott H Harrison, Changyu Shen, Haixu Tang, Predrag Radivojac, Randy J Arnold, Xiang Zhang and Jake Yue Chen
    Citation: BMC Medical Genomics 2008 1:12
  35. Dupuytren's contracture (DC) is the most common inherited connective tissue disease of humans and is hypothesized to be associated with aberrant wound healing of the palmar fascia. Fibroblasts and myofibroblas...

    Authors: Latha Satish, William A LaFramboise, David B O'Gorman, Sandra Johnson, Benjamin Janto, Bing Siang Gan, Mark E Baratz, Fen Z Hu, J Christopher Post, Garth D Ehrlich and Sandeep Kathju
    Citation: BMC Medical Genomics 2008 1:10
  36. Molecular characterization of breast and other cancers by gene expression profiling has corroborated existing classifications and revealed novel subtypes. Most profiling studies are based on fresh frozen (FF) ...

    Authors: Andrea Oberli, Vlad Popovici, Mauro Delorenzi, Anna Baltzer, Janine Antonov, Sybille Matthey, Stefan Aebi, Hans Jörg Altermatt and Rolf Jaggi
    Citation: BMC Medical Genomics 2008 1:9
  37. Pterostilbene, a naturally occurring phenolic compound produced by agronomically important plant genera such as Vitis and Vacciunium, is a phytoalexin exhibiting potent antifungal activity. Additionally, recent s...

    Authors: Zhiqiang Pan, Ameeta K Agarwal, Tao Xu, Qin Feng, Scott R Baerson, Stephen O Duke and Agnes M Rimando
    Citation: BMC Medical Genomics 2008 1:7
  38. Midkine is a heparin-binding growth factor that is over-expressed in various human cancers and plays important roles in cell transformation, growth, survival, migration, and angiogenesis. However, little is kn...

    Authors: Zongbing You, Ying Dong, Xiangtian Kong, Laurel A Beckett, Regina Gandour-Edwards and Jonathan Melamed
    Citation: BMC Medical Genomics 2008 1:6
  39. Arrayed primer extension (APEX) is a microarray-based rapid minisequencing methodology that may have utility in 'personalized medicine' applications that involve genetic diagnostics of single nucleotide polymo...

    Authors: Mohua Podder, Jian Ruan, Ben W Tripp, Zane E Chu and Scott J Tebbutt
    Citation: BMC Medical Genomics 2008 1:5
  40. Although the PBS-IIc SELDI-TOF MS apparatus has been extensively used in the search for better biomarkers, issues have been raised concerning the semi-quantitative nature of the technique and its reproducibili...

    Authors: Marie-Christine W Gast, Judith YMN Engwegen, Jan HM Schellens and Jos H Beijnen
    Citation: BMC Medical Genomics 2008 1:4
  41. Urothelial carcinoma (UC) is characterized by nonrandom chromosomal aberrations, varying from one or a few changes in early-stage and low-grade tumors, to highly rearranged karyotypes in muscle-invasive lesion...

    Authors: Markus Heidenblad, David Lindgren, Tord Jonson, Fredrik Liedberg, Srinivas Veerla, Gunilla Chebil, Sigurdur Gudjonsson, Åke Borg, Wiking Månsson and Mattias Höglund
    Citation: BMC Medical Genomics 2008 1:3
  42. The early detection of prostate cancer has resulted in an increase in the number of patients with localized prostate cancer and has paralleled the reported reduction in prostate cancer mortality. The increased...

    Authors: Timothy J McDonnell, Nikhil S Chari, Jeong Hee Cho-Vega, Patricia Troncoso, Xuemei Wang, Carlos E Bueso-Ramos, Kevin Coombes, Shawn Brisbay, Remigio Lopez, George Prendergast, Christopher Logothetis and Kim-Anh Do
    Citation: BMC Medical Genomics 2008 1:1

Annual Journal Metrics

  • 2022 Citation Impact
    2.7 - 2-year Impact Factor
    3.2 - 5-year Impact Factor
    0.730 - SNIP (Source Normalized Impact per Paper)
    0.892 - SJR (SCImago Journal Rank)

    2022 Speed
    26 days submission to first editorial decision for all manuscripts (Median)
    160 days submission to accept (Median)

    2022 Usage 
    1,437 Altmetric mentions 

Peer-review Terminology

  • The following summary describes the peer review process for this journal:

    Identity transparency: Single anonymized

    Reviewer interacts with: Editor

    Review information published: Review reports. Reviewer Identities reviewer opt in. Author/reviewer communication

    More information is available here

Sign up for article alerts and news from this journal