Santos FP, Quintas-Cardama A: New drugs for chronic myelogenous leukemia. Curr Hematol Malig Rep. 2011, 6: 96-103. 10.1007/s11899-011-0079-9.
Article
PubMed
Google Scholar
Tang M, Gonen M, Quintas-Cardama A, Cortes J, Kantarjian H, Field C, Hughes TP, Branford S, Michor F: Dynamics of chronic myeloid leukemia response to long-term targeted therapy reveal treatment effects on leukemic stem cells. Blood. 2011, 118: 1622-1631. 10.1182/blood-2011-02-339267.
Article
CAS
PubMed
PubMed Central
Google Scholar
Quintas-Cardama A, Cortes J: Molecular biology of bcr-abl1-positive chronic myeloid leukemia. Blood. 2009, 113: 1619-1630. 10.1182/blood-2008-03-144790.
Article
CAS
PubMed
PubMed Central
Google Scholar
Deininger MW: Milestones and monitoring in patients with CML treated with imatinib. Hematology Am Soc Hematol Educ Program. 2008, 2008: 419-426. 10.1182/asheducation-2008.1.419.
Google Scholar
Baccarani M, Cortes J, Pane F, Niederwieser D, Saglio G, Apperley J, Cervantes F, Deininger M, Gratwohl A, Guilhot F, et al: Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet. J Clin Oncol. 2009, 27: 6041-6051. 10.1200/JCO.2009.25.0779.
Article
CAS
PubMed
Google Scholar
Saglio G, Baccarani M: First-line therapy for chronic myeloid leukemia: new horizons and an update. Clin Lymphoma Myeloma Leuk. 2010, 10: 169-176. 10.3816/CLML.2010.n.026.
Article
CAS
PubMed
Google Scholar
Deininger M: Resistance and relapse with imatinib in CML: causes and consequences. J Natl Compr Canc Netw. 2008, 6 (Suppl 2): S11-S21.
CAS
PubMed
Google Scholar
Jabbour E, Cortes J, Giles F, O'Brien S, Kantarjian H: The clinical challenge of imatinib resistance in chronic myeloid leukemia: emerging strategies with new targeted agents. Targ Oncol. 2006, 1: 186-196. 10.1007/s11523-006-0032-3.
Article
Google Scholar
Coude MM, Luycx O, Cariou ME, Maarek O, Dombret H, Cayuela JM, Rea D: Undetectable molecular residual disease after omacetaxine and nilotinib combination therapy in an imatinib-resistant chronic myeloid leukaemia patient harbouring the BCR-ABL1 T315I gatekeeper mutation. Br J Haematol. 2012, 157: 407-410. 10.1111/j.1365-2141.2011.09016.x.
Article
CAS
PubMed
Google Scholar
Kim TD, Frick M, le Coutre P: Omacetaxine mepesuccinate for the treatment of leukemia. Expert Opin Pharmacother. 2011, 12: 2381-2392. 10.1517/14656566.2011.613378.
Article
CAS
PubMed
Google Scholar
Allan EK, Holyoake TL, Craig AR, Jorgensen HG: Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells. Leukemia. 2011, 25: 985-994. 10.1038/leu.2011.55.
Article
CAS
PubMed
Google Scholar
Quintas-Cardama A, Cortes J: Omacetaxine mepesuccinate–a semisynthetic formulation of the natural antitumoral alkaloid homoharringtonine, for chronic myelocytic leukemia and other myeloid malignancies. IDrugs. 2008, 11: 356-372.
CAS
PubMed
Google Scholar
Wetzler M, Segal D: Omacetaxine as an anticancer therapeutic: what is old is new again. Curr Pharm Des. 2011, 17: 59-64. 10.2174/138161211795049778.
Article
CAS
PubMed
Google Scholar
Smith BD: Imatinib for chronic myeloid leukemia: the impact of its effectiveness and long-term side effects. J Natl Cancer Inst. 2011, 103: 527-529. 10.1093/jnci/djr073.
Article
CAS
PubMed
Google Scholar
Seiter K: Update of recent studies in chronic myeloid leukemia. J Hematol Oncol. 2009, 2 (Suppl 1): A2-10.1186/1756-8722-2-S1-A2.
Article
PubMed Central
Google Scholar
Baran Y, Zencir S, Cakir Z, Ozturk E, Topcu Z: Imatinib-induced apoptosis: a possible link to topoisomerase enzyme inhibition. J Clin Pharm Ther. 2011, 36: 673-679. 10.1111/j.1365-2710.2010.01224.x.
Article
CAS
PubMed
Google Scholar
Liu XY, Yang YF, Wu CT, Xiao FJ, Zhang QW, Ma XN, Li QF, Yan J, Wang H, Wang LS: Spred2 is involved in imatinib-induced cytotoxicity in chronic myeloid leukemia cells. Biochem Biophys Res Commun. 2010, 393: 637-642. 10.1016/j.bbrc.2010.02.044.
Article
CAS
PubMed
Google Scholar
Shingu T, Fujiwara K, Bogler O, Akiyama Y, Moritake K, Shinojima N, Tamada Y, Yokoyama T, Kondo S: Stage-specific effect of inhibition of autophagy on chemotherapy-induced cytotoxicity. Autophagy. 2009, 5: 537-539. 10.4161/auto.5.4.8164.
Article
CAS
PubMed
Google Scholar
Shingu T, Fujiwara K, Bogler O, Akiyama Y, Moritake K, Shinojima N, Tamada Y, Yokoyama T, Kondo S: Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells. Int J Cancer. 2009, 124: 1060-1071. 10.1002/ijc.24030.
Article
CAS
PubMed
Google Scholar
Nemati F, Mathiot C, Grandjean I, Lantz O, Bordier V, Dewulf S, Ekue R, Di Santo JP, Poupon MF, Decaudin D: Imatinib mesylate reduces rituximab-induced tumor-growth inhibition in vivo on Epstein-Barr virus-associated human B-cell lymphoma. Anticancer drugs. 2007, 18: 1029-1037. 10.1097/CAD.0b013e3281e444cb.
Article
CAS
PubMed
Google Scholar
Kuroda J, Kimura S, Strasser A, Andreeff M, O'Reilly LA, Ashihara E, Kamitsuji Y, Yokota A, Kawata E, Takeuchi M, et al: Apoptosis-based dual molecular targeting by INNO-406, a second-generation Bcr-Abl inhibitor, and ABT-737, an inhibitor of antiapoptotic Bcl-2 proteins, against Bcr-Abl-positive leukemia. Cell Death Differ. 2007, 14: 1667-1677. 10.1038/sj.cdd.4402168.
Article
CAS
PubMed
Google Scholar
Kuroda J, Puthalakath H, Cragg MS, Kelly PN, Bouillet P, Huang DC, Kimura S, Ottmann OG, Druker BJ, Villunger A, et al: Bim and Bad mediate imatinib-induced killing of Bcr/Abl+leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic. Proc Natl Acad Sci U S A. 2006, 103: 14907-14912. 10.1073/pnas.0606176103.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mitchell BD, Kammerer CM, Blangero J, Mahaney MC, Rainwater DL, Dyke B, Hixson JE, Henkel RD, Sharp RM, Comuzzie AG: Genetic and environmental contributions to cardiovascular risk factors in Mexican Americans. The San Antonio Family Heart Study. Circulation. 1996, 94: 2159-2170. 10.1161/01.CIR.94.9.2159.
Article
CAS
PubMed
Google Scholar
Watters JW, Kraja A, Meucci MA, Province MA, McLeod HL: Genome-wide discovery of loci influencing chemotherapy cytotoxicity. Proc Natl Acad Sci U S A. 2004, 101: 11809-11814. 10.1073/pnas.0404580101.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sarma SN, Kim YJ, Ryu JC: Gene expression profiles of human promyelocytic leukemia cell lines exposed to volatile organic compounds. Toxicology. 2010, 271: 122-130. 10.1016/j.tox.2010.03.014.
Article
CAS
PubMed
Google Scholar
Rojas M, Wright CW, Pina B, Portugal J: Genomewide expression profiling of cryptolepine-induced toxicity in Saccharomyces cerevisiae. Antimicrob Agents Chemother. 2008, 52: 3844-3850. 10.1128/AAC.00532-08.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hooyberghs J, Schoeters E, Lambrechts N, Nelissen I, Witters H, Schoeters G, Van Den Heuvel R: A cell-based in vitro alternative to identify skin sensitizers by gene expression. Toxicol Appl Pharmacol. 2008, 231: 103-111. 10.1016/j.taap.2008.03.014.
Article
CAS
PubMed
Google Scholar
Krishnaswamy R, Devaraj SN, Padma VV: Lutein protects HT-29 cells against Deoxynivalenol-induced oxidative stress and apoptosis: prevention of NF-kappaB nuclear localization and down regulation of NF-kappaB and Cyclo-Oxygenase-2 expression. Free Radic Biol Med. 2010, 49: 50-60. 10.1016/j.freeradbiomed.2010.03.016.
Article
CAS
PubMed
Google Scholar
Goring HH, Curran JE, Johnson MP, Dyer TD, Charlesworth J, Cole SA, Jowett JB, Abraham LJ, Rainwater DL, Comuzzie AG, et al: Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes. Nat Genet. 2007, 39: 1208-1216. 10.1038/ng2119.
Article
PubMed
Google Scholar
Newson R, Team AS: Software update: st0035_1: Multiple-test procedures and smile plots. Stata J. 2010, 10: 691-692.
Google Scholar
Alexandersson A: ellip. Stata Bulletin. 2010, 46: gr32.
Google Scholar
Almasy L, Blangero J: Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet. 1998, 62: 1198-1211. 10.1086/301844.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ledet-Jensen CL, Ørntoft T: Normalization of real-time quantitative RT-PCR data: a model based variance estimation approach to identify genes suited for normalization – applied to bladder- and colon-cancer data-sets. Cancer Res. 2004, 64: 5245-5250. 10.1158/0008-5472.CAN-04-0496.
Article
Google Scholar
Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 2001, 25: 402-408. 10.1006/meth.2001.1262.
Article
CAS
PubMed
Google Scholar
da Huang W, Sherman BT, Tan Q, Collins JR, Alvord WG, Roayaei J, Stephens R, Baseler MW, Lane HC, Lempicki RA: The DAVID gene functional classification tool: a novel biological module-centric algorithm to functionally analyze large gene lists. Genome Biol. 2007, 8: R183-10.1186/gb-2007-8-9-r183.
Article
PubMed
Google Scholar
da Huang W, Sherman BT, Tan Q, Kir J, Liu D, Bryant D, Guo Y, Stephens R, Baseler MW, Lane HC, Lempicki RA: DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists. Nucleic Acids Res. 2007, 35: W169-175. 10.1093/nar/gkm415.
Article
PubMed
Google Scholar
Wang Y, Yang Z, Zhao X: Honokiol induces paraptosis and apoptosis and exhibits schedule-dependent synergy in combination with imatinib in human leukemia cells. Toxicol Mech Methods. 2010, 20: 234-241. 10.3109/15376511003758831.
Article
CAS
PubMed
Google Scholar
Basciani S, Vona R, Matarrese P, Ascione B, Mariani S, Cauda R, Gnessi L, Malorni W, Straface E, Lucia MB: Imatinib interferes with survival of multi drug resistant Kaposi's sarcoma cells. FEBS Lett. 2007, 581: 5897-5903. 10.1016/j.febslet.2007.11.069.
Article
CAS
PubMed
Google Scholar
dos Santos SC, Sa-Correia I: Genome-wide identification of genes required for yeast growth under imatinib stress: vacuolar H+−ATPase function is an important target of this anticancer drug. OMICS. 2009, 13: 185-198. 10.1089/omi.2008.0086.
Article
CAS
PubMed
Google Scholar
Pardanani A, Vannucchi AM, Passamonti F, Cervantes F, Barbui T, Tefferi A: JAK inhibitor therapy for myelofibrosis: critical assessment of value and limitations. Leukemia. 2011, 25: 218-225. 10.1038/leu.2010.269.
Article
CAS
PubMed
Google Scholar
Grosso S, Puissant A, Dufies M, Colosetti P, Jacquel A, Lebrigand K, Barbry P, Deckert M, Cassuto JP, Mari B, Auberger P: Gene expression profiling of imatinib and PD166326-resistant CML cell lines identifies Fyn as a gene associated with resistance to BCR-ABL inhibitors. Mol Cancer Ther. 2009, 8: 1924-1933.
Article
CAS
PubMed
Google Scholar
Park ES, Shaughnessy JD, Gupta S, Wang H, Lee JS, Woo HG, Zhan F, Owens JD, Potter M, Janz S, Mushinski JF: Gene expression profiling reveals different pathways related to Abl and other genes that cooperate with c-Myc in a model of plasma cell neoplasia. BMC genomics. 2007, 8: 302-10.1186/1471-2164-8-302.
Article
PubMed
PubMed Central
Google Scholar
Ozturk K, Avcu F, Ugur Ural A: Aberrant expressions of leptin and adiponectin receptor isoforms in chronic myeloid leukemia patients. Cytokine. 2012, 57: 61-67. 10.1016/j.cyto.2011.10.004.
Article
CAS
PubMed
Google Scholar
Alonci A, Allegra A, Russo S, Penna G, Bellomo G, D'Angelo A, Campo S, Cannavo A, Centorrino R, Musolino C: Imatinib mesylate therapy induces reduction in neutrophil gelatinase-associated lipocalin serum levels and increase in leptin concentrations in chronic myeloid leukemia patients in molecular remission. Acta Haematol. 2012, 127: 1-6. 10.1159/000330948.
Article
CAS
PubMed
Google Scholar
Eisele YS, Baumann M, Klebl B, Nordhammer C, Jucker M, Kilger E: Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin. Mol Biol Cell. 2007, 18: 3591-3600. 10.1091/mbc.E07-01-0035.
Article
CAS
PubMed
PubMed Central
Google Scholar
Netzer WJ, Dou F, Cai D, Veach D, Jean S, Li Y, Bornmann WG, Clarkson B, Xu H, Greengard P: Gleevec inhibits beta-amyloid production but not Notch cleavage. Proc Natl Acad Sci U S A. 2003, 100: 12444-12449. 10.1073/pnas.1534745100.
Article
CAS
PubMed
PubMed Central
Google Scholar
Seggewiss R, Lore K, Greiner E, Magnusson MK, Price DA, Douek DC, Dunbar CE, Wiestner A: Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner. Blood. 2005, 105: 2473-2479. 10.1182/blood-2004-07-2527.
Article
CAS
PubMed
Google Scholar
Leguay T, Foucaud C, Parrens M, Fitoussi O, Bouabdallah K, Belaud-Rotureau MA, Tabrizi R, Marit G, Pigneux A, Milpied N: EBV-positive lymphoproliferative disease with medullary, splenic and hepatic infiltration after imatinib mesylate therapy for chronic myeloid leukemia. Leukemia. 2007, 21: 2208-2210. 10.1038/sj.leu.2404758.
Article
CAS
PubMed
Google Scholar
Bekkenk MW, Vermeer MH, Meijer CJ, Jansen PM, Middeldorp JM, Stevens SJ, Willemze R: EBV-positive cutaneous B-cell lymphoproliferative disease after imatinib mesylate. Blood. 2003, 102: 4243-10.1182/blood-2003-07-2436.
Article
CAS
PubMed
Google Scholar
Morey JS, Ryan JC, Van Dolah FM: Microarray validation: factors influencing correlation between oligonucleotide microarrays and real-time PCR. Biological Proced Online. 2006, 8: 175-193. 10.1251/bpo126.
Article
CAS
Google Scholar